Patents by Inventor David Graef

David Graef has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11827695
    Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: November 28, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael K. Ahlijanian, Jere Ernest Meredith, Jr., Nino Devidze, John David Graef, Edward L. Halk
  • Patent number: 11142570
    Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: October 12, 2021
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Michael K. Ahlijanian, Jere Ernest Meredith, Jr., Nino Devidze, John David Graef, Edward L. Halk
  • Publication number: 20210221878
    Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.
    Type: Application
    Filed: January 19, 2021
    Publication date: July 22, 2021
    Inventors: Michael K. AHLIJANIAN, Jere Ernest MEREDITH, Jr., Nino DEVIDZE, John David GRAEF, Edward L. HALK
  • Publication number: 20200231661
    Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.
    Type: Application
    Filed: February 16, 2018
    Publication date: July 23, 2020
    Inventors: Michael K. AHLIJANIAN, Jere Ernest MEREDITH, Jr., Nino DEVIDZE, John David GRAEF, Edward L. HALK
  • Patent number: 8532953
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously, It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: September 10, 2013
    Assignee: Teledyne LeCroy, Inc.
    Inventors: Anthony Cake, Peter J Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
  • Patent number: 8386208
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method includes the steps of indicating one or more anomalies to be found, loading a first trigger configuration to the test and measurement apparatus and determining for a first predetermined time period whether an input signal generates a trigger related to one or more of the one or more anomalies. A second trigger configuration is loaded to the test and measurement apparatus upon the conclusion of the first predetermined time, and for a second predetermined time it is determined whether the input signal generates a trigger related to one or more of the one or more anomalies.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: February 26, 2013
    Assignee: Teledyne LeCroy, Inc.
    Inventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
  • Publication number: 20120173188
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously, It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.
    Type: Application
    Filed: March 6, 2012
    Publication date: July 5, 2012
    Applicant: LeCroy Corporation
    Inventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
  • Patent number: 8190392
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously. It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: May 29, 2012
    Assignee: LeCroy Corporation
    Inventors: Anthony Cake, Peter J Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
  • Publication number: 20120041720
    Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: LeCroy Corporation
    Inventors: Peter James Pupalaikis, David Graef
  • Publication number: 20110286506
    Abstract: A signal integrity network analyzer is provided. The analyzer preferably includes a characterization module for characterizing a device under test, an acquisition module for acquiring a waveform, a de-embedding module for selectively embedding and de-embedding on or more system fixtures, and an analysis module for performing analysis on the acquired waveform, with one or more system features selectively embedded or de-embedded. A single user interface is provided and is adapted to control the characterization module, the acquisition module, the de-embedding module and the analysis module.
    Type: Application
    Filed: September 28, 2010
    Publication date: November 24, 2011
    Applicant: LeCroy Corporation
    Inventors: Jonathan Libby, Hitesh Patel, Peter J. Pupalaikis, David Graef
  • Publication number: 20100244811
    Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.
    Type: Application
    Filed: December 22, 2009
    Publication date: September 30, 2010
    Applicant: LeCroy Corporation
    Inventors: Peter J. Pupalaikis, David Graef
  • Publication number: 20090281758
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to the test and measurement apparatus and determining for a first predetermined time whether an input signal generates a trigger. Thereafter, a second trigger configuration is loaded to the test and measurement apparatus upon the conclusion of the first predetermined time and for a second predetermined time it is determined whether the input signal generates a trigger.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 12, 2009
    Applicant: LeCroy Corporation
    Inventors: Anthony Cake, Peter J. Pupalaikis, David Graef, William Driver, Michael Hertz
  • Publication number: 20090281748
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of indicating one or more anomalies to be found, loading a first trigger configuration to the test and measurement apparatus and determining for a first predetermined time whether an input signal generates a trigger related to one or more of the one or more anomalies. A second trigger configuration is loaded to the test and measurement apparatus upon the conclusion of the first predetermined time, and for a second predetermined time it is determined whether the input signal generates a trigger related to one or more of the one or more anomalies.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 12, 2009
    Applicant: LeCroy Corporation
    Inventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
  • Publication number: 20090281759
    Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously. It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.
    Type: Application
    Filed: July 29, 2008
    Publication date: November 12, 2009
    Applicant: LeCroy Corporation
    Inventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
  • Publication number: 20080258957
    Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.
    Type: Application
    Filed: April 15, 2008
    Publication date: October 23, 2008
    Applicant: LeCroy Corporation
    Inventors: Peter James Pupalaikis, David Graef
  • Patent number: 7373281
    Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: May 13, 2008
    Assignee: LeCroy Corporation
    Inventors: Peter James Pupalaikis, David Graef
  • Publication number: 20070185669
    Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.
    Type: Application
    Filed: March 29, 2007
    Publication date: August 9, 2007
    Applicant: LeCroy Corporation
    Inventors: Peter Pupalaikis, David Graef
  • Publication number: 20070027658
    Abstract: A method and apparatus for digitizing a data signal, the method comprising the steps of receiving an input analog data signal, splitting the received input analog data signal into a plurality of split signals, and mixing at least one of the split signals with a predetermined periodic function with a predetermined frequency. The split signals are then digitized and combined mathematically to form a single output data stream that is a substantially correct representation of the original input signal.
    Type: Application
    Filed: September 22, 2006
    Publication date: February 1, 2007
    Inventors: Peter Pupalaikis, David Graef
  • Publication number: 20060161401
    Abstract: A method and apparatus for digitizing a data signal, the method comprising the steps of receiving an input analog data signal, splitting the received input analog data signal into a plurality of split signals, and mixing at least one of the split signals with a predetermined periodic function with a predetermined frequency. The split signals are then digitized and combined mathematically to form a single output data stream that is a substantially correct representation of the original input signal.
    Type: Application
    Filed: November 22, 2005
    Publication date: July 20, 2006
    Inventors: Peter Pupalaikis, David Graef
  • Publication number: 20060080065
    Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, use of frequency up-conversion and down-conversion techniques to achieve a system bandwidth that significantly exceeds the bandwidth attainable through interleaving alone. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content. In this manner preferred embodiments achieve the significant advantage that bandwidth may be enhanced beyond the limits associated with interleaving and the state of the art in amplifier and ADC design.
    Type: Application
    Filed: November 17, 2005
    Publication date: April 13, 2006
    Applicant: LeCroy Corporation
    Inventors: Peter Pupalaikis, David Graef