Patents by Inventor David Graef
David Graef has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11827695Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.Type: GrantFiled: January 19, 2021Date of Patent: November 28, 2023Assignee: Bristol-Myers Squibb CompanyInventors: Michael K. Ahlijanian, Jere Ernest Meredith, Jr., Nino Devidze, John David Graef, Edward L. Halk
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Patent number: 11142570Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.Type: GrantFiled: February 16, 2018Date of Patent: October 12, 2021Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Michael K. Ahlijanian, Jere Ernest Meredith, Jr., Nino Devidze, John David Graef, Edward L. Halk
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Publication number: 20210221878Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.Type: ApplicationFiled: January 19, 2021Publication date: July 22, 2021Inventors: Michael K. AHLIJANIAN, Jere Ernest MEREDITH, Jr., Nino DEVIDZE, John David GRAEF, Edward L. HALK
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Publication number: 20200231661Abstract: Disclosed herein are anti-?-synuclein antibodies which preferentially bind to oligomeric ?-synuclein over monomeric ?-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.Type: ApplicationFiled: February 16, 2018Publication date: July 23, 2020Inventors: Michael K. AHLIJANIAN, Jere Ernest MEREDITH, Jr., Nino DEVIDZE, John David GRAEF, Edward L. HALK
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Patent number: 8532953Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously, It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.Type: GrantFiled: March 6, 2012Date of Patent: September 10, 2013Assignee: Teledyne LeCroy, Inc.Inventors: Anthony Cake, Peter J Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
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Patent number: 8386208Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method includes the steps of indicating one or more anomalies to be found, loading a first trigger configuration to the test and measurement apparatus and determining for a first predetermined time period whether an input signal generates a trigger related to one or more of the one or more anomalies. A second trigger configuration is loaded to the test and measurement apparatus upon the conclusion of the first predetermined time, and for a second predetermined time it is determined whether the input signal generates a trigger related to one or more of the one or more anomalies.Type: GrantFiled: June 27, 2008Date of Patent: February 26, 2013Assignee: Teledyne LeCroy, Inc.Inventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
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Publication number: 20120173188Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously, It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.Type: ApplicationFiled: March 6, 2012Publication date: July 5, 2012Applicant: LeCroy CorporationInventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
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Patent number: 8190392Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously. It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.Type: GrantFiled: July 29, 2008Date of Patent: May 29, 2012Assignee: LeCroy CorporationInventors: Anthony Cake, Peter J Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
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Publication number: 20120041720Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.Type: ApplicationFiled: October 27, 2011Publication date: February 16, 2012Applicant: LeCroy CorporationInventors: Peter James Pupalaikis, David Graef
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Publication number: 20110286506Abstract: A signal integrity network analyzer is provided. The analyzer preferably includes a characterization module for characterizing a device under test, an acquisition module for acquiring a waveform, a de-embedding module for selectively embedding and de-embedding on or more system fixtures, and an analysis module for performing analysis on the acquired waveform, with one or more system features selectively embedded or de-embedded. A single user interface is provided and is adapted to control the characterization module, the acquisition module, the de-embedding module and the analysis module.Type: ApplicationFiled: September 28, 2010Publication date: November 24, 2011Applicant: LeCroy CorporationInventors: Jonathan Libby, Hitesh Patel, Peter J. Pupalaikis, David Graef
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Publication number: 20100244811Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.Type: ApplicationFiled: December 22, 2009Publication date: September 30, 2010Applicant: LeCroy CorporationInventors: Peter J. Pupalaikis, David Graef
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Publication number: 20090281758Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to the test and measurement apparatus and determining for a first predetermined time whether an input signal generates a trigger. Thereafter, a second trigger configuration is loaded to the test and measurement apparatus upon the conclusion of the first predetermined time and for a second predetermined time it is determined whether the input signal generates a trigger.Type: ApplicationFiled: May 8, 2008Publication date: November 12, 2009Applicant: LeCroy CorporationInventors: Anthony Cake, Peter J. Pupalaikis, David Graef, William Driver, Michael Hertz
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Publication number: 20090281748Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of indicating one or more anomalies to be found, loading a first trigger configuration to the test and measurement apparatus and determining for a first predetermined time whether an input signal generates a trigger related to one or more of the one or more anomalies. A second trigger configuration is loaded to the test and measurement apparatus upon the conclusion of the first predetermined time, and for a second predetermined time it is determined whether the input signal generates a trigger related to one or more of the one or more anomalies.Type: ApplicationFiled: June 27, 2008Publication date: November 12, 2009Applicant: LeCroy CorporationInventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
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Publication number: 20090281759Abstract: A method and apparatus for determining a trigger in a test and measurement apparatus are provided. The method comprises the steps of loading a first trigger configuration to a first trigger element of the test and measurement apparatus and loading a second trigger configuration to a second trigger element of the test and measurement apparatus so that these trigger elements operate substantially simultaneously. It is then determined whether the input signal generates a trigger in accordance with the one or more trigger configurations.Type: ApplicationFiled: July 29, 2008Publication date: November 12, 2009Applicant: LeCroy CorporationInventors: Anthony Cake, Peter Pupalaikis, David Graef, William Driver, Michael Hertz, Laxmikant Joshi
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Publication number: 20080258957Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.Type: ApplicationFiled: April 15, 2008Publication date: October 23, 2008Applicant: LeCroy CorporationInventors: Peter James Pupalaikis, David Graef
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Patent number: 7373281Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.Type: GrantFiled: March 29, 2007Date of Patent: May 13, 2008Assignee: LeCroy CorporationInventors: Peter James Pupalaikis, David Graef
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Publication number: 20070185669Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, the use of frequency up-conversion and down-conversion techniques. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content.Type: ApplicationFiled: March 29, 2007Publication date: August 9, 2007Applicant: LeCroy CorporationInventors: Peter Pupalaikis, David Graef
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Publication number: 20070027658Abstract: A method and apparatus for digitizing a data signal, the method comprising the steps of receiving an input analog data signal, splitting the received input analog data signal into a plurality of split signals, and mixing at least one of the split signals with a predetermined periodic function with a predetermined frequency. The split signals are then digitized and combined mathematically to form a single output data stream that is a substantially correct representation of the original input signal.Type: ApplicationFiled: September 22, 2006Publication date: February 1, 2007Inventors: Peter Pupalaikis, David Graef
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Publication number: 20060161401Abstract: A method and apparatus for digitizing a data signal, the method comprising the steps of receiving an input analog data signal, splitting the received input analog data signal into a plurality of split signals, and mixing at least one of the split signals with a predetermined periodic function with a predetermined frequency. The split signals are then digitized and combined mathematically to form a single output data stream that is a substantially correct representation of the original input signal.Type: ApplicationFiled: November 22, 2005Publication date: July 20, 2006Inventors: Peter Pupalaikis, David Graef
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Publication number: 20060080065Abstract: A method for improving bandwidth of an oscilloscope involves, in preferred embodiments, use of frequency up-conversion and down-conversion techniques to achieve a system bandwidth that significantly exceeds the bandwidth attainable through interleaving alone. In an illustrative embodiment the technique involves separating an input signal into a high frequency content and a low frequency content, down-converting the high frequency content in the analog domain so that it may be processed by the oscilloscope's analog front end, digitizing the low frequency content and the down-converted high frequency content, and forming a digital representation of the received analog signal from the digitized low frequency content and high frequency content. In this manner preferred embodiments achieve the significant advantage that bandwidth may be enhanced beyond the limits associated with interleaving and the state of the art in amplifier and ADC design.Type: ApplicationFiled: November 17, 2005Publication date: April 13, 2006Applicant: LeCroy CorporationInventors: Peter Pupalaikis, David Graef