Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A fluid distribution system includes a first flow meter configured to be positioned along an agent line, a metering valve configured to be positioned downstream of the first flow meter, a second flow meter configured to be positioned downstream of the first flow meter and an eductor, and a controller configured to selectively operate the fluid distribution system in a testing mode where the controller is configured to acquire a first flow rate of a fluid flowing through the first flow meter and a second flow rate of the fluid flowing through the second flow meter, determine a performance characteristic based on the first flow rate and the second flow rate, and modulate a current setting of the metering valve from a first setting to a second setting and conduct the testing mode sequence again at the second setting to verify the fluid distribution system is performing properly.

Abstract: A fire fighting vehicle includes a powertrain including an engine, a battery pack, and an electromechanical transmission; a power divider; and a controller. The power divider is positioned between the engine, the pump, and the electromechanical transmission. The controller is configured to monitor a state-of-charge of the battery pack and operate the engine, the power divider, and the electromechanical transmission such that the state-of-charge is maintained above a minimum state-of-charge threshold that is sufficient to facilitate (i) accelerating the fire fighting vehicle to a driving speed of at least 50 miles-per-hour in an acceleration time and (ii) maintaining or exceeding the driving speed for a period of time. An aggregate of the acceleration time and the period of time is at least three minutes.

Abstract: An infotainment system for a motor vehicle includes a display screen positioned to be visible by a passenger of the motor vehicle. A storage arrangement stores a collection of video segments to be presented on the display screen. The storage arrangement also stores metadata in association with the video segments. A user interface receives inputs from the passenger. A sensor detects a characteristic of the passenger. A processing arrangement is communicatively coupled to each of the display screen, the collection of video segments, the user interface and the sensor. The processing arrangement selects one of the video segments to present on the display screen. The selecting of the one video segment is dependent upon inputs received from the passenger via the user interface, signals received from the sensor indicative of the characteristic of the passenger, and metadata associated with individual segments.

Abstract: A fire-fighting vehicle includes a boom assembly movably coupled to a chassis, a penetrating nozzle coupled to the boom assembly, an actuator that moves the penetrating nozzle relative to the chassis, and a controller operatively coupled to a sensor. The penetrating nozzle includes a piercing tip and an outlet configured to be selectively fluidly coupled to a supply of fire suppressant. The piercing tip is repositionable relative to a surface of an object having an interior cavity. The outlet supplies fire suppressant into the interior cavity when the piercing tip is within the interior cavity. The sensor provides data relating to at least one of a position and an orientation of the piercing tip relative to the surface. The controller determines an angular orientation of the piercing tip relative to the surface based on the data.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: A fluid distribution system includes a water line configured to receive water from a water source, an agent line configured to receive agent from an agent source, a flush line configured to receive the water from the water source and connecting to the agent line at a junction, a flush valve positioned to selectively prevent the water from flowing along the flush line, an agent valve positioned to selectively prevent the agent from flowing along the agent line, a first flow meter positioned along the agent line downstream of the junction, a second flow meter positioned downstream of the first flow meter, an eductor coupled to the agent line and the water line downstream of the first flow meter and upstream of the second flow meter, a metering valve positioned downstream of the first flow meter and upstream of the eductor, and a controller.

Abstract: The present disclosure provides compositions and foods that selectively promote the representation and expressed beneficial function of members of a human gut community in ways that promote a healthy gut microbiota and in turn positively impact health. Various examples of compositions and foods, which comprise one or more fiber preparation, are discussed in detail, as are methods of their use.

Abstract: A head up display arrangement for a motor vehicle includes a head up display module having a picture generation unit emitting a light field. A plurality of linear polarizers are arranged in a stack. A first of the linear polarizers receives the light field from the picture generation unit. A last of the linear polarizers emits the light field. A windshield reflects the light field from the last linear polarizer such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A head up display arrangement for a motor vehicle includes a head up display producing a virtual image that is visible to a driver of the motor vehicle when he is sitting in a driver's seat and his eyes are above a first vertical level and below a second vertical level. An eye tracking system detects a vertical level of the eyes of the driver and transmits a height signal indicative of the detected vertical level of the eyes of the driver. A motorized seat height adjustment module adjusts a vertical level of the driver's seat. An electronic controller is communicatively coupled to the eye tracking system and to the motorized seat height adjustment module. The electronic controller controls the motorized seat height adjustment module based on the height signal to move the driver's eyes to a vertical position above the first vertical level and below the second vertical level.

Abstract: A head up display arrangement for a motor vehicle includes a head up display module having a picture generation unit emitting a light field. A plurality of linear polarizers are arranged in a stack. A first of the linear polarizers receives the light field from the picture generation unit. A last of the linear polarizers emits the light field. A windshield reflects the light field from the last linear polarizer such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image.

Abstract: A targeting guide is disclosed includes a handle extending substantially along a longitudinal axis. The longitudinal handle defines one or more burr holes extending from a first side of the handle to a second side of the handle. A head is coupled to a distal end of the longitudinal handle. The head defines a plurality of guide holes sized and configured to receive a k-wire therethrough.

Abstract: A fire fighting vehicle includes a chassis, tractive elements coupled to the chassis, a pump coupled to the chassis, a discharge fluidly coupled to the pump, an accessory module coupled to the chassis, and an electric motor coupled to the chassis, the pump, and the accessory module. The accessory module is configured to receive a mechanical energy input and provide at least one of electrical energy or fluid energy. The electric motor is configured to provide mechanical energy to drive (a) the pump to provide fluid to the discharge such that the fluid is expelled from the discharge and (b) the accessory module to provide the at least one of electrical energy or fluid energy.

Abstract: A motor vehicle includes a rearview camera capturing images of a scene behind the motor vehicle. An electronic processor receives the images captured by the camera. A virtual image projection arrangement is communicatively coupled to the electronic processor and presents a virtual image dependent upon the images captured by the camera. The virtual image is visible by a driver of the vehicle after being reflected by a windshield.

Abstract: A fire fighting vehicle includes a chassis, tractive elements coupled to the chassis, a pump coupled to the chassis, a discharge fluidly coupled to the pump, an accessory module coupled to the chassis, and an electric motor coupled to the chassis, the pump, and the accessory module. The accessory module is configured to receive mechanical energy and provide at least one of electrical energy or fluid energy. The electric motor is configured to drive (a) the pump to provide fluid to the discharge such that the fluid is expelled from the discharge and (b) the accessory module to provide the at least one of electrical energy or fluid energy.

Abstract: A head up display arrangement for a motor vehicle includes a source of a first video signal. A driver monitor system detects a location of at least a portion of a human driver of the motor vehicle. An electronic processor is communicatively coupled to the first video signal source and to the driver monitor system. The electronic processor produces a second video signal that is dependent upon the first video signal and that includes parallax information. The parallax information is based on the detected location of the portion of the driver. A head up display projection device produces a virtual image that is visible to the driver and that is based upon the second video signal.

Abstract: A head up display arrangement is for a motor vehicle having a human occupant. A light source emits a light field. An infrared camera detects infrared energy. A combiner is positioned and configured to reflect the light field such that the light field can be viewed by the human occupant as a virtual image. The combiner has a region configured to reflect infra-red energy emitted by a face of the occupant such that the infrared energy is received by the infrared camera.

Abstract: A motor vehicle includes a rearview camera capturing images of a scene behind the motor vehicle. An electronic processor receives the images captured by the camera. A virtual image projection arrangement is communicatively coupled to the electronic processor and presents a virtual image dependent upon the images captured by the camera. The virtual image is visible by a driver of the vehicle after being reflected by a windshield.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.