Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: An agent distribution system includes a water tank, a flush line, a flush valve, an agent storage tank, an agent line, an agent valve, a first flow meter, and a second flow meter. The flush line receives water from the water tank. The flush valve is configured to selectively prevent water from flowing along the flush line downstream of the flush valve. The agent line receives agent from the agent tank. The agent valve is configured to selectively prevent agent from flowing along the agent line downstream of the agent valve. The flush line extends into the agent line at a junction. The junction is disposed downstream of the agent valve. The first flow meter is positioned along the agent line downstream of the junction. The second flow meter is positioned downstream of the first flow meter and upstream of a discharge system.

Abstract: A motor vehicle includes a head up display projector producing a light field based upon image data such that the light field is reflected off of a windshield of the motor vehicle and is then visible to a driver of the motor vehicle as a virtual image. First means determines locations of physical objects visible to the driver through the windshield. Second means determines locations of eyes of the driver. An electronic processor receives first data indicative of the determined locations of the physical objects, and receives second data indicative of the determined locations of the eyes of the driver. The electronic processor produces the image data dependent upon the first data and the second data such that a symbol in the virtual image appears to be in a predetermined position relative to a selected one of the physical objects.

Abstract: Systems and methods are described herein for performing actions based on a determined intent within messages received by a mobile device. In some embodiments, the systems and methods may access a message received by a mobile application (e.g., text messaging application, chat application, and so on) of the mobile device, analyze the message to determine an intent of the message (e.g., whether the message includes a request or a task for a recipient of the message), and perform an action based on the determined intent (e.g., set a reminder when the message includes a task for the recipient). Further details are described herein.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A head up display arrangement is for a motor vehicle having a human occupant. A light source emits a light field. An infrared camera detects infrared energy. A combiner is positioned and configured to reflect the light field such that the light field can be viewed by the human occupant as a virtual image. The combiner has a region configured to reflect infra-red energy emitted by a face of the occupant such that the infrared energy is received by the infrared camera.

Abstract: A communication apparatus includes a controller. The controller is configured to: receive a message, such as a communication request; determine a type for said message; select a first recipient layer based on said type, said first recipient layer comprising at least one recipient; transmit said message to at least one of said at least one recipient of said first recipient layer; receive a confirmation from said at least one of said at least one recipient of said first recipient layer; and in response thereto transmit said confirmation from said at least one of said at least one recipient of said first recipient layer to at least another one of said at least one recipient of said first recipient layer.

Abstract: A head up display arrangement for a motor vehicle includes a head up display module having a picture generation unit emitting a light field. A plurality of linear polarizers are arranged in a stack. A first of the linear polarizers receives the light field from the picture generation unit. A last of the linear polarizers emits the light field. A windshield reflects the light field from the last linear polarizer such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A vehicle includes a chassis, a driveline and an accessory coupled to the chassis and configured to receive rotational mechanical energy, a first driver and a second driver coupled to the chassis and configured to provide rotational mechanical energy, and a power transmission device. The power transmission device includes a housing coupled to the chassis, a first input shaft configured to receive the rotational mechanical energy from the first driver, a second input shaft configured to receive the rotational mechanical energy from the second driver, a primary output interface coupled to the driveline, a power takeoff shaft radially aligned with the first input shaft and coupled to the accessory, a first clutch configured to selectively rotationally couple the first input shaft to the primary output interface, and a second clutch configured to selectively rotationally couple the first input shaft to the power takeoff shaft.

Abstract: A head up display arrangement for a motor vehicle includes a head up display projector including a lens with a polarizer. The head up display projector emits a linearly polarized light field via the lens. A windshield reflects the light field such that the reflected light field is visible to a human driver of the motor vehicle as a virtual image. The windshield includes an outer plastic layer sandwiched between a half-wave plate and an outer glass layer. An inner plastic layer is sandwiched between the half-wave plate and an inner glass layer.

Abstract: A fire-fighting vehicle includes a boom assembly movably coupled to a chassis, a penetrating nozzle coupled to the boom assembly, an actuator that moves the penetrating nozzle relative to the chassis, and a controller operatively coupled to a sensor. The penetrating nozzle includes a piercing tip and an outlet configured to be selectively fluidly coupled to a supply of fire suppressant. The piercing tip is repositionable relative to a surface of an object having an interior cavity. The outlet supplies fire suppressant into the interior cavity when the piercing tip is within the interior cavity. The sensor provides data relating to at least one of a position and an orientation of the piercing tip relative to the surface. The controller determines an angular orientation of the piercing tip relative to the surface based on the data.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: An orthopedic plate is specifically configured for use in osteotomies, in which part of the plate extends into a portion of a first bone segment and part is external to the cortical surface of an adjacent bone segment to fix the segments to allow them to fuse. The plate has a first end and a second end where the end which is inserted into the bone has a chamfer and a through hole having a hole axis optionally at an oblique angle to the longitudinal axis of the plate, and which can receive a screw, peg or pin. The second end of the plate includes a locking screw hole and optionally including a compression slot extending in a direction toward a screw hole in the opposing end. Optionally, the non-locking hole has a shroud that forms an arc or portion of a cylinder over the hole. A plate driver having a recess that holds the plate is used to insert the plate into the bone.

Abstract: A communication apparatus includes a controller. The controller is configured to: receive a message, such as a communication request; determine a type for said message; select a first recipient layer based on said type, said first recipient layer comprising at least one recipient; transmit said message to at least one of said at least one recipient of said first recipient layer; receive a confirmation from said at least one of said at least one recipient of said first recipient layer; and in response thereto transmit said confirmation from said at least one of said at least one recipient of said first recipient layer to at least another one of said at least one recipient of said first recipient layer.

Abstract: A fire-fighting vehicle includes a boom assembly movably coupled to a chassis, a penetrating nozzle coupled to the boom assembly, an actuator that moves the penetrating nozzle relative to the chassis, and a controller operatively coupled to a sensor. The penetrating nozzle includes a piercing tip and an outlet configured to be selectively fluidly coupled to a supply of fire suppressant. The piercing tip is repositionable between a first position spaced from a surface of an object and a second position within an interior cavity of the object. The outlet supplies fire suppressant into the interior cavity when the piercing tip is in the second position. The sensor provides data relating to at least one of a position and an orientation of the piercing tip relative to the surface. The controller determines an angular orientation of the piercing tip relative to the surface based on the data.

Abstract: A multi-sensory sensor comprises at least a first and a second sensor element, wherein the multi-sensory sensor is adapted for attachment to a movable structure in a building. The multi-sensory sensor is operatively associated with a controller that is configured to receive input from said first sensor element, wherein the input is indicative of a movement of the movable structure. The controller is further configured to receive input from the second sensor element, and indirectly identify a human behavioral action in the building based on a combination of the input from the first sensor element and the input from the second sensor element. It is further configured to determine a function to be taken based on the identified action, and cause the function to be taken to be executed. In one embodiment the first sensor is a movement sensor element for sensing a movement and the second sensor element is an audio sensor element for sensing audio.

Abstract: A device for stabilising a ladder against a surface, the ladder having a pair of stiles and a plurality of rungs connected therebetween, the device comprising: an engagement mechanism for releasably engaging two adjacent rungs, the engagement mechanism including two opposed receiving portions for at least partially receiving a rung, at least one of the receiving portions being selectively movable relative to the other thereby allowing the engagement mechanism to urge against the adjacent rungs; and at least one arm pivotably connected to the engagement mechanism to allow pivoting thereof to a fixed angle relative to the engagement mechanism, the at least one arm having an abutting portion for abutting under the surface, thereby allowing the ladder to be wedged between the surface and ground level to stabilise the ladder.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A communication system provides remote care taking of a first user to be cared for by a plurality of second users. The system has a first mobile communication terminal configured for use by the first user to be cared for, and a plurality of second mobile communication terminals for use by the second users. Each second mobile communication terminal is configured to let the respective second user act as a member of a first recipient layer or a member of a second recipient layer. The first mobile communication terminal is configured to allow the first user to select a first element in a user interface of the first mobile communication terminal to cause sending of a first type of remote care taking request message intended for second users being members of the first recipient layer, the first type of request message pertaining to remote care taking of the first user.