Abstract: A device includes a first body having a curved wall with a top surface that slopes away from the first body and a second body having an interior configured to receive the curved wall of the first body, the interior including a curved ramp with a sloped bottom ramp surface. The second body is mounted on the first body with the bottom surface of the curved ramp resting on the top surface of the curved wall. A compressible seal extends from the first body bottom, and a shaft projects from the second body through a passage in the first body and into the interior of the compressible seal. Rotating the bodies relative to each other causes the shaft to pull the seal against the first body and radially expand the seal against an interior wall of an opening in which the device is placed to form a seal therewith.

Abstract: A server system stores a hosted conversation having a special-purpose automated participant and a standard participant. The server system receives a request to modify the conversation from a first participant, determines a set of edits that update the conversation to an updated state in accordance with the request to modify the conversation; and sends, the set of edits to a second participant. When the first participant is a standard participant: the request includes an indication of preliminary edits; the conversation is updated in accordance with the preliminary edits; and the set of edits include concurrency-resolved edits. When the first participant is a special-purpose automated participant: the request includes an operation to be performed on the conversation; the operation is performed on the conversation at the server system; and the set of edits updates the conversation, in accordance with the operation.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.

Abstract: A tire assembly is disclosed, wherein the tire has a tread portion and a pair of sidewalls extending radially inward from the tread portion to join with a respective bead; a supporting carcass for the tread portion and sidewalls; and a pump passageway positioned within a bending region of the tire. The pump passageway is operative to open and close as the tire rotates. The tire assembly further includes a valve assembly in fluid communication with the pump passageway. The tire further includes a pocket formed in the tire, and a filter assembly is mounted in the pocket.

Abstract: An article is worn by a user. A plurality of indicating devices are coupled to the article. A processing unit is communicatively coupled to the plurality of indicating devices. The processing unit selectively actuates at least one indicating device of the plurality of indicating devices based on positional data.

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Abstract: Disclosed herein is a method and system for integrating an enterprise's structured and unstructured data to provide users and enterprise applications with efficient and intelligent access to that data. In accordance with exemplary embodiments, the generation of metadata indexes about unstructured data can be hardware-accelerated by processing streaming unstructured data through a reconfigurable logic device to generate the metadata about the unstructured data for the index.

Abstract: An apparatus adapted for presenting a sheet of media to an image transfer structure. The apparatus includes a registration baffle positioned in an offset relationship relative to the image transfer structure and a pre-transfer baffle assembly including a first baffle oppositely disposed to a second baffle, the pre-transfer assembly generally forms an “S” shape and is adapted for guiding the sheet of media from the registration baffle to the image transfer structure. The pre-transfer baffle assembly is arranged in a first position adapted for guiding the sheet of media toward the image transfer structure at an angle of less than ninety degrees, and the pre-transfer baffle automatically begins rotation to a second position as the sheet of media reaches a pre-determined position within a paper path.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:

Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.

Abstract: A device includes a first body having a curved wall with a top surface that slopes away from the first body and a second body having an interior configured to receive the curved wall of the first body, the interior including a curved ramp with a sloped bottom ramp surface. The second body is mounted on the first body with the bottom surface of the curved ramp resting on the top surface of the curved wall. A compressible seal extends from the first body bottom, and a shaft projects from the second body through a passage in the first body and into the interior of the compressible seal. Rotating the bodies relative to each other causes the shaft to pull the seal against the first body and radially expand the seal against an interior wall of an opening in which the device is placed to form a seal therewith.

Abstract: A device for at least partially blocking an opening includes a first body, a second body rotatably mounted to the first body and a compressible seal extending from the first body. The seal includes a first portion, a plate having a hole at one end of the first portion, and a second portion extending away from the plate. A hollow shaft extends from the second body and through the first body, the first portion, the hole in the plate, and into the second portion. The shaft has a shoulder in the second portion that is wider than the hole in the plate, and moving the shaft relative to the first body compresses the second body until the shoulder reaches the plate and then compresses the first body. Such compression expands the first and/or second portions and presses them against the inside of the opening to form a seal.

Abstract: Techniques for combining the results of multiple recognizers in a distributed speech recognition architecture. Speech data input to a client device is encoded and processed both locally and remotely by different recognizers configured to be proficient at different speech recognition tasks. The client/server architecture is configurable to enable network providers to specify a policy directed to a trade-off between reducing recognition latency perceived by a user and usage of network resources. The results of the local and remote speech recognition engines are combined based, at least in part, on logic stored by one or more components of the client/server architecture.

Abstract: This invention presents a method for overcoming limitation in brightness and heating effects for LED based Precision Approach Path Indicators and allowing both colors to be imaged in the far field with the proper abrupt transition between the red and white sectors. This method relies on the use of linear arrays of LED's and cylindrical optics.

Abstract: The present invention discloses ?-diketones, ?-diketones or ?-hydroxyketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: The present invention is embodied in an eyewear lens with at least two controlled, limited visible light blocking filters that attenuate its transmittance spectrum. More specifically, in the present invention, the eyewear lens attenuates limited amounts of light in at least two visible wavelength regions via controlled, limited blocking filters, wherein the overall luminous transmittance is at least 75%. The at least two controlled, limited blocking filters have their peak blocking wavelengths in the region of 410-500 nm and 530-620 nm, respectively. In a preferred embodiment, the minimum transmittance that occurs within the 410-500 nm region is ?55% and the minimum transmittance that occurs within the 530-620 nm region is ?65%. In another preferred embodiment, the eyewear lens comprises an anti-reflective coating on its inner surface (the eye-side of the lens).

Abstract: Methods and computer readable medium for collaborating on geographical maps between two or more computers are disclosed. In particular, sharing a geographical location on a map between two or more computers and co-navigating a map between two or more computers are disclosed. With respect to sharing a geographical location, the geographical location is retrieved to the first computer. The geographical location is added to the map being rendered at the first computer and is sent to a second computer. A map including the geographical location is rendered at the second computer. With respect to co-navigating, a map is displayed from a map perspective at the first computer. The map perspective is sent to the second computer. A map from the same map perspective being displayed at the first computer is rendered at the second computer.

Abstract: Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers: