Abstract: Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A moveable control surface mounting rib assembly (110) comprises a rib (144) which is attached to one side of a spar member (112) and a stiffener (160) attached to another side of the spar member. The stiffener abuts the upper and lower flanges of the spar member in order to react the loads. The invention is applicable to the mounting of any movable control surface.

Abstract: A vehicle lock and personal protection baton uses a telescoping construction to combine an elongated base and an elongated extension. The elongated extension slides within the elongated base in order to switch between configurations, specifically for use as a lock or for use as a protection baton. A locking mechanism couples the elongated extension with the elongated base, and a user can easily twist the locking mechanism to allow or prevent sliding of the elongated extension with respect to the elongated base. The elongated extension includes an end segment with one or more intermediate segments to allow for greater length. The end segment is slidably engaged with the intermediate segment, allowing the end segment to telescope with the intermediate segment. A first brace and second brace are connected to opposite ends of the telescoping body and inserted between a door frame and handle to lock a vehicle from the interior.

Abstract: A method for the detection of a target nucleic acid, which method comprises contacting template nucleic acid from a sample with (i) a signalling system and (ii) a tailed nucleic acid primer having a template binding region and the tail comprising a linker and a target binding region, in the presence of appropriate nucleoside triphosphates and an agent for polymerisation thereof, under conditions such that the template binding region of the primer will hybridise to a complementary sequence in the template nucleic acid and be extended to form a primer extension product, separating any such product from the template whereupon the target binding region in the tail of the primer will hybridise to a sequence in the primer extension product corresponding to the target nucleic acid, and wherein any such target specific hybridisation causes a detectable change in the signalling system, such that the presence or absence of the target nucleic acid in the sample is detected by reference to the presence or absence of a de

Abstract: Methods and apparatus to apply multiple trip limits to a device in a process control system are disclosed. An example method involves monitoring a value of a parameter associated with the operation of the device and receiving an input indicative of an operational state of the device, where a first input indicates a first operational state and a second input indicates a second operational state. If the first input is received, comparing via a function block the value of the parameter to a first trip limit, and if the second input is received, comparing via the function block the value of the parameter to a second trip limit, and implementing a response based on the comparison.

Abstract: Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.

Abstract: A center section/motor sub-assembly for use in a hydrostatic transmission includes a center section having a pump running face for interfacing with a pump, and a motor running face for interfacing with a motor. The center section and the motor are configured for the hydraulic separating forces of the motor to be reacted only into the center section. The center section has two internal passages between pump kidney ports and motor kidney port, and the motor kidney ports are raised in elevation relative to the pump kidney ports. The internal passages run parallel to each other as they rise in elevation. A hydrostatic transmission includes the sub-assembly enclosed by a housing, in combination with a pump and output shaft assembly. For installation, the output shaft assembly is configured as a separate component from the sub-assembly of the center section and the motor.

Abstract: A method for bonding the tail of a convolutely wound log to the body is provided. The method comprises the use of a nonadhesive phase-change material to mechanically bond the tail to the wound log. The nonadhesive phase-change material is heated to an amorphous state prior to its application. Once applied to the wound log, the nonadhesive phase-change material mechanical bonds with the tail and wound log and as heat is lost, changes to a non-amorphous state. The mechanical bond can be selectively reversed through the application of a strength degradation accelerator.

Abstract: Cleaning systems and devices are provided for cleaning body-inserted tubes (e.g., endotracheal tubes, chest cleaning tubes). In one embodiment, a closed suction system comprises a suction catheter having at least one deployable (e.g., inflatable) cleaning member at a distal portion of the suction catheter and at least one suction opening distal to the cleaning member. The closed suction system module may comprise a control unit at its proximal end adapted to facilitate operation in one of the following three operational states: i) a first operational state in which only the cleaning member is functional, ii) a second operational state in which only suction is functional, or iii) a third operational state in which neither suction nor the cleaning member is functional.

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: A center section/motor sub-assembly for use in a hydrostatic transmission includes a center section having a pump running face for interfacing with a pump and a motor running face for interfacing with a motor, and a bore extending laterally through the center section from the motor running face. A spool valve is received in the bore and includes a fluid pathway for providing fluid communication between the pump running face and the motor running face. The sub-assembly further includes a motor having a rotor and a motor stator secured to the center section adjacent to the motor running face in a manner that permits rotation of the rotor. The center section is configured for the hydraulic separating forces of the motor to be reacted only into the center section. A hydrostatic transmission includes the sub-assembly enclosed by a housing, in combination with a pump and output shaft.

Abstract: In one aspect, a system for presenting a share box with content information in response to an endorsement includes an endorsement sharing module that is responsive to user input and creates a sharing box having content derived from the user context and input request. The endorsement sharing module receives a user request to share information. In response, this endorsement sharing module determines the context of the user, retrieves content based on the context, filters the content based on publisher information, personalizes the share box content, and adds the content to a share box. The endorsement sharing module also adds one or more actions to the share box after which the share box is provided for display to the user.

Abstract: A method including: displacing a plurality of sheets through a defined portion of a process path; generating, using an encoder, a first number of encoder pulses associated with displacing a first sheet from the plurality of sheets along the defined portion; applying first indicia to a first side of the first sheet; displacing the first sheet through the defined portion; generating, using the encoder, a second number of encoder pulses associated with displacing the first sheet along the defined portion; calculating, using a processor, a ratio including the first and second numbers; applying second indicia to the respective second side of the first sheet or third indicia to the respective first side of a second sheet from the plurality of sheets, or fourth indicia to the respective second side of the second sheet; and adjusting, using the processor, application of the second, third, or fourth indicia according to the ratio.

Abstract: A method for improving the energy efficiency of a pump system. The method includes measuring an instantaneous power consumption of the pump system, measuring an instantaneous fluid flow rate of the pump system, and determining an instantaneous specific energy consumption (SEC) of the pump system based on the instantaneous power consumption and the instantaneous fluid flow rate. The method then adjusts the speed of a pump in response to the determined SEC. The above steps may be performed a number of times to seek a reduced value of the instantaneous SEC of the pump system.

Abstract: Techniques for combining the results of multiple recognizers in a distributed speech recognition architecture. Speech data input to a client device is encoded and processed both locally and remotely by different recognizers configured to be proficient at different speech recognition tasks. The client/server architecture is configurable to enable network providers to specify a policy directed to a trade-off between reducing recognition latency perceived by a user and usage of network resources. The results of the local and remote speech recognition engines are combined based, at least in part, on logic stored by one or more components of the client/server architecture. An indication of the availability of the remote speech recognition to perform speech recognition at a point in time may be provided to a user of the client device via a user interface of the client device.

Abstract: Access between a data terminal 1 and a data network 5 by way of a first wireless-enabled access point 3 is restored after a primary connection 4 between the first access point and the data network is lost by having the access point 3 scan for a further wireless-enabled access point 6 and establishing a wireless connection between the first access point 3 and the further access point 6 such that the data terminals 1 etc can connect to the data network by way of the access points 3, 6 and the wireless connection between them.

Abstract: A vehicle includes a pump having a swash plate tiltable about a swashplate tilt axis, wherein rotation of the swashplate changes the title angle and effects a change in volumetric displacement of the pump. A controller is operatively coupled to the swashplate to effect rotation of the swashplate, the controller including a processor and memory, and logic stored in the memory and executable by the processor, the logic configured to automatically control at least one vehicle characteristic independent of a user input command.

Abstract: A device for at least partially blocking an opening includes a first body, a second body rotatably mounted to the first body and a compressible seal extending from the first body. The seal includes a first portion, a plate having a hole at one end of the first portion, and a second portion extending away from the plate. A hollow shaft extends from the second body and through the first body, the first portion, the hole in the plate, and into the second portion. The shaft has a shoulder in the second portion that is wider than the hole in the plate, and moving the shaft relative to the first body compresses the second body until the shoulder reaches the plate and then compresses the first body. Such compression expands the first and/or second portions and presses them against the inside of the opening to form a seal.

Abstract: In the event of loss of connection (4) between an access point (3) and a data network (5), the access point (3) transmits instructions to a data processing device (1) connected to the access point (3) to cause the data processing device (1) to re-establish connection to the data network (5) by another means. These instructions cause the data processing device to scan for beacon signals from further wireless access points, and establish connection (7, 8) to the data network (5) through a wireless access point (6) identified in the scanning process.

Abstract: An acoustical and rain clearing window assembly for a vehicle includes a window panel mounted to the vehicle and at least one exciter attached to the window panel. An exciter control unit is connected to the at least one exciter and is configured to generate a superposition wave form for communication to the at least one exciter to simultaneously produce audio sound within the vehicle and clear water from the window panel. The exciter control unit is electrically connected to a first mode switch for receiving a first input signal to initiate the production of audio sound within the vehicle and a second mode switch for receiving a second input signal to initiate the clearing of water from the window panel. The exciter control unit is configured to receive the first and second input signals and combine the first and second input signals into the superposition wave form.