Abstract: This invention relates to compositions and methods for modulating cellular activity of non-human organisms, and in particular fungi, and methods of identifying and using antifungal agents with improved specificity. More particularly, the technology described herein relates to the identification and use of compounds that target intron-encoded proteins, such as maturases.

Abstract: An instrument, in particular an electron microscope, has at least one user controllable operating parameter and at least one further operating parameter having a required value at least partially dependent on that of the user controllable parameter. A number of possible values of the further operating parameter are stored in a memory and each stored value corresponds to a respective possible value of the user controllable parameter. Selecting one of said stored possible values causes the instrument to be controlled accordingly. There is also provided a tuner for enabling the user to alter the selected value and updating apparatus for updating the memory accordingly, so that the adjusted value of the further operating parameter is subsequently selected from the memory if the same value of the user controllable parameter is then chosen again.

Abstract: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of in multiple selected genes to identify individuals with increased or decreased risk of breast cancer. In addition, personal history measures such as age and family history are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment.

Abstract: A system and method for interfacing a simulation device with a gaming device is disclosed. The system comprises a video game controller and a sensor. The controller is configured to mimic certain aspects of standard game controllers, providing control functions to a video game, with added functionality to accept input of an external control signal. The game controller is further configured to allow one or more of its control functions to be overridden by control functions provided by the external control signal. The sensor measures simulation parameters representative of actions performed on the simulation device and outputs simulation control signals representative of the simulation parameters. The sensor simulation control signals may be input to the game controller to provide control functions to the video game using both the simulation device and the game controller.

Abstract: The present invention generally relates to systems, methods and applications utilizing the convergence of any combination of the following three technologies: wireless positioning or localization technology, wireless communications technology and sensor technology. In particular, certain embodiments of the present invention relate to a remote device that includes a sensor for determining or measuring a desired parameter, a receiver for receiving position data from the Global Positioning System (GPS) satellite system, a processor for determining whether or not alert conditions are present and a wireless transceiver for transmitting the measured parameter data and the position data to a central station, such as an application service provider (ASP). The ASP, in turn, may communicate the measured data, position data and notification of any alerts to an end user via an alert device. The present invention also relates to various applications and systems utilizing the capabilities of such a device.

Abstract: Disclosed are diagnostic techniques for the detection of human disease states that affect gene expression in peripheral leukocytes. The invention relates particularly to probes and methods for evaluating the presence of RNA species that are differentially expressed in the peripheral blood of individuals with such a disease state compared to normal healthy individuals. The invention further relates to methods for detection of protein species that are differentially expressed in the peripheral blood of individuals with such a disease state compared to normal healthy individuals. Genetic probes, antibody probes and methods useful in monitoring the progression and diagnosis of two specific disease states, prostatic cancer and breast cancer, are described.

Abstract: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of selected genes, and particular combinations of genotypes, to identify individuals with increased or decreased risk of breast cancer. In addition, personal history measures such as age and race are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment.

Abstract: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal history measures such as age and race are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment.

Abstract: A method of fabricating integrated circuits from a plurality of semiconductor dice, each semiconductor die defining a top side and a bottom side, includes the steps of attaching the bottom sides of the plurality of semiconductor dice to a substrate so that the plurality of semiconductor dice are in adjacent disposition and define one or more bending regions; creating a thin film interconnect on the top sides of the plurality of semiconductor dice and over one or more die gap regions so that the plurality of semiconductor dice are electrically interconnected; removing the substrate from the bottom sides of the plurality of semiconductor dice; and bending the thin film interconnect at the one or more die gap regions so that the bottom sides and the top sides of the semiconductor dice overlap to form a stacked plurality of semiconductor dice.

Abstract: A process for treating waste products discharged in a waste water from an animal operation, such as a swine confinement facility includes a holding tank for receiving waste water from the flushing of the facility in which solids to accumulate at the bottom thereof; wherein as conveyor transfers solids from said bottom at a rate preventing agitation of the waste water, to a compactor for removing additional water content and to a product dryer for converting the solids into a dry product. The product dryer includes a water heating system with water lines connected in a closed loop to the holding tank. The heating system thermal treats the circulating waste water and waste solids to a temperature sufficient to reduce undesired constituents therein. The product dryer is vented to a separator for recovering ammonia contents in the waste material.

Abstract: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal history measures such as age and race are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment.

Abstract: A window decal form is suitable for laser printing and enables ready installation of a decal to the inside of a vehicle window or the like. The window decal form construction includes a liner sheet having a front side and a back side. An adhesive release coating is disposed on the back side of the liner sheet framing a decal area. The decal area and the adhesive release coating define a label area. The label is affixed to the back side of the liner sheet covering the label area via a permanent adhesive. The decal area on the front side of the liner sheet is die cut such that the decal area is removed when the label is peeled from the back side of the liner sheet.

Abstract: An apparatus and method for continuous, passive detection and measurement of tensile and compressional strain in a structure utilizing a shielded optic fiber, the optic fiber having one or more Bragg gratings thereon, the gratings and shield being disposed in a curved path on the structure and a baseline response for the grating is made using an optical source and detector. Changes in tensile or compressional forces on the structure will result in changes in the curve of the grating, resulting in a frequency shift for the returned light.

Abstract: Methods and computer readable media for statistically identifying an increased risk for disease. In one embodiment, resampling techniques are utilized to consider different genotype combinations within a resampling subset of a case/control data set. Odds-ratios and theoretical p-values are calculated for each genotype combination so that an increased risk of disease associated with a particular genotype combination may be identified. In another embodiment, different genotype combinations within a case/control data set are considered. Odds ratios are calculated for each genotype combination. Empirical p-values are calculated for the odds ratios through randomization techniques. Using the odds-ratios and/or empirical p-values, an increased risk for disease associated with a particular genotype combination may be identified.

Abstract: The present invention generally relates to systems, methods and applications utilizing the convergence of any combination of the following three technologies: wireless positioning or localization technology, wireless communications technology and sensor technology. In particular, certain embodiments of the present invention relate to a remote device that includes a sensor for determining or measuring a desired parameter, a receiver for receiving position data from the Global Positioning System (GPS) satellite system, a processor for determining whether or not alert conditions are present and a wireless transceiver for transmitting the measured parameter data and the position data to a central station, such as an application service provider (ASP). The ASP, in turn, may communicate the measured data, position data and notification of any alerts to an end user via an alert device. The present invention also relates to various applications and systems utilizing the capabilities of such a device.

Abstract: A composite label form includes a release liner coated with an adhesive release material. A first label of a first material includes an adhesive on a back surface and is releasably attached to the release liner. At least one space is die cut from the first material, and a second label of a second material different from the first material is releasably attached to the same release liner. The second material also includes an adhesive on a back surface thereof. The label form may also include a backer die cut adjacent at least one of the first label or the second label such that a portion of the release liner will be removed when the adjacent label is removed from the liner. This construction provides for multiple label types on a single release liner, with or without a backer die cut.

Abstract: A control housing body (10) containing a cavity (12) of sufficient size to allow entry and movement by a human thumb, and capable of housing a number of controls (14, 16). Body (10) is inserted under a covering grip (33) that is connected in line with a surface grip (32) of a rotating steering device (31). Dial control (14) is provided to set a scalar variable such as vehicular speed at a constant number. A thumb rest (13) and a control guard (17) inhibit the thumb from slipping downwards and unintentionally activating a contracting control (16) that can be actuated by the contracting movement of a human thumb. A sliding cover (40) can be alternately positioned over cavity (12) or inside retraction slot (46). A pivoting pin (22) and pivoting rotator (24) allow the control housing body to rotate around the axis between two pivot holes (26) and (28).

Abstract: This invention relates to compositions and methods for modulating cellular activity of non-human organisms, and in particular fungi, and methods of identifying and using antifungal agents with improved specificity. More particularly, the technology described herein relates to the identification and use of compounds that target intron-encoded proteins, such as maturases.

Abstract: A window decal form is suitable for laser printing and enables ready installation of a decal to the inside of a vehicle window or the like. The window decal form construction includes a liner sheet having a front side and a back side. An adhesive release coating is disposed on the back side of the liner sheet framing a decal area. The decal area and the adhesive release coating define a label area. The label is affixed to the back side of the liner sheet covering the label area via a permanent adhesive. The decal area on the front side of the liner sheet is die cut such that the decal area is removed when the label is peeled from the back side of the liner sheet.

Abstract: An apparatus and method for continuous, passive detecting and measuring of compressional strains in real time, without physical intervention, which comprises: