Patents by Inventor David Ralph
David Ralph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11263403Abstract: A method includes identifying a set of identigens for each word of a first phrase of a phrase group to produce a first plurality of sets of identigens and determining whether first and second identigen rules are applicable to the first plurality of sets of identigens. When the first and second identigen rules are applicable to the first plurality of sets of identigens, the method further includes identifying a set of identigens for each word of a second phrase of the phrase group to produce a second plurality of sets of identigens and determining that the first identigen rules are applicable to the second plurality of sets of identigens. The method further includes identifying one valid identigen of each set of identigens of the first plurality of sets of identigens by applying the first identigen rules to the first plurality of sets of identigens to produce a first entigen group.Type: GrantFiled: September 17, 2019Date of Patent: March 1, 2022Assignee: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Dennis Arlen Roberson, Stephen Emerson Sundberg, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Gary W. Grube
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Patent number: 11232260Abstract: A method includes generating a new entigen group regarding trusted new information. The method further includes generating entigen groups from phrases of a document and determining whether an entigen group of the entigen groups has a most likely meaning similar to a most likely meaning of the new entigen group. When the entigen group has a most likely meaning similar to the most likely meaning of the new entigen group, the method further includes updating the entigen group based on the new entigen group. When the entigen groups do not include an entigen group having a most likely meaning similar to the most likely meaning of the new entigen group, the method further includes updating the entigen groups to include the new entigen group.Type: GrantFiled: April 16, 2019Date of Patent: January 25, 2022Assignee: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Donald Joseph Wurzel, Paige Kristen Thompson, Stephen Emerson Sundberg, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Eric Andrew Faurie, Theodore Mazurkiewicz, Gary W. Grube
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Publication number: 20220010036Abstract: Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.Type: ApplicationFiled: July 8, 2021Publication date: January 13, 2022Inventors: Jeffery Arnold, David A. Ralph
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Publication number: 20210374167Abstract: A method executed by a computing device includes determining a set of identigens for each query word of a query to produce sets of identigens. The method further includes interpreting the sets of identigens to produce different first and second query entigen groups. The method further includes generating an interim response based on the first and second query entigen groups. The method further includes determining a set of identigens for each updated query word of an updated query to produce updated sets of identigens. The method further includes selecting one of the first or second query entigen group based on the updated sets of identigens to produce a selected query entigen group. The method further includes generating a response entigen group utilizing the selected query entigen group and generating a response to the query utilizing the response entigen group.Type: ApplicationFiled: May 24, 2021Publication date: December 2, 2021Applicant: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Donald Joseph Wurzel, Stephen Emerson Sundberg, Ameeta Vasant Reed, Dennis Arlen Roberson, Thomas James MacTavish, Karl Olaf Knutson, Jessy Thomas, Niklas Josiah MacTavish, David Michael Corns, II, Andrew Chu, Theodore Mazurkiewicz, Gary W. Grube
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Publication number: 20210370311Abstract: A method for execution by a computing device includes obtaining a set of media element identigens for media elements of media to produce sets of media element identigens. The sets of media element identigens are possible interpretations of a media element. The method further includes generating a set of relationships between media elements. The relationships provide a list of one or more ways in which the media elements are related. The method further includes processing different permutations of the sets of media element identigens using the set of relationships to generate an entigen group. The entigen group represents a most likely interpretation of the media.Type: ApplicationFiled: August 17, 2021Publication date: December 2, 2021Applicant: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Gary W. Grube
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Patent number: 11176126Abstract: A method includes generating an initial entigen group for a query from existing entigens in a knowledge database and determining whether the initial entigen group provides a reliable response to the query. When the initial entigen group does not provide a reliable response to the query, the method further includes determining a desired entigen to add to the initial entigen group to produce an updated entigen group that leads to the reliable response to the query and creating the desired entigen based on obtained targeted data. The method further includes adding the desired entigen to the initial entigen group to produce the updated entigen group and determining whether the updated entigen group provides the reliable response to the query. When the updated entigen group provides the reliable response to the query, the method further includes outputting the reliable response.Type: GrantFiled: July 25, 2019Date of Patent: November 16, 2021Assignee: entigenlogic LLCInventors: Donald Joseph Wurzel, Frank John Williams, David Ralph Lazzara, Stephen Chen, Dennis Arlen Roberson, Andrew Chu, Gary W. Grube
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Publication number: 20210338827Abstract: Compositions and methods of using these compositions that can include a targeting moiety and a therapeutic agent are described herein. These compositions can be used for diagnosing and/or treating flaviviridae-family viruses including Zika virus, dengue virus, and yellow fever.Type: ApplicationFiled: May 18, 2021Publication date: November 4, 2021Inventors: Frederick O. Cope, David A. Ralph
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Patent number: 11100324Abstract: A method includes obtaining a set of image segment identigens for each image segment of an image to produce sets of image segment identigens. The sets of image segment identigens are possible interpretations of an image segment. The method further includes generating a set of relationships between image segments. The relationships provide a list of one or more ways in which the image segments are related. The method further includes processing different permutations of the sets of image segment identigens in accordance with the set of relationships to generate an entigen group. The entigen group represents a most likely interpretation of the image.Type: GrantFiled: May 20, 2019Date of Patent: August 24, 2021Assignee: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Gary W. Grube
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Publication number: 20210209975Abstract: A system for simultaneously producing immersive visual effects on an inside of an enclosure and passive visual effects to be viewed from the outside of the enclosure. The enclosure includes a plurality of sidewalls each having a reflective inner surface facing one other. The system includes a digital video display positioned to direct digital video imagery through the semi-reflective sidewall and into the enclosure. Light of the digital video imagery reflects off the reflective inner surfaces of plurality of sidewalls, which allow a percentage of the light to leave the enclosure, making the visual effects observable from the outside. The light will continue this cycle of reflection and transmission, creating an observable infinity effect from the outside, and an entirely enclosed visual experience from the inside.Type: ApplicationFiled: March 19, 2021Publication date: July 8, 2021Inventor: David Ralph Cicirelli
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Publication number: 20210191922Abstract: A method executed by a computing device includes obtaining a string of words and determining whether two or more words of the string of words are in a word group. When the two or more words are in the word group, the method further includes determining a set of identigens for each word of the word group to produce sets of identigens, where a set of identigens of the sets of identigens represents one or more different meanings of a word of the word group. The method further includes interpreting, using identigen pairing rules, the sets of identigens to produce an entigen group. The method further includes assigning a new entigen to represent the entigen group, where the new entigen represents a most likely meaning interpretation of the word group.Type: ApplicationFiled: March 5, 2021Publication date: June 24, 2021Applicant: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Donald Joseph Wurzel, Paige Kristen Thompson, Stephen Emerson Sundberg, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Eric Andrew Faurie, Theodore Mazurkiewicz, Gary W. Grube
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Publication number: 20210145989Abstract: Disclosed is a method for increase target specificity of a mannosylated dextran therapeutic or diagnostic compound by administering at least a blocking composition comprising a backbone and one or more CD206 targeting moieties attached thereto; administering an effective amount of the mannosylated dextran therapeutic or diagnostic compound comprising a dextran backbone and one or more CD206 targeting moieties and one or more therapeutic agents attached thereto. In exemplary implementations, the molecular mass of the blocking composition backbone is at least about two times larger than the molecular mass of the mannosylated dextran backbone compound.Type: ApplicationFiled: September 30, 2020Publication date: May 20, 2021Inventors: David A. Ralph, Jeffery Arnold
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Patent number: 11007272Abstract: Compositions and methods of using these compositions that can include a targeting moiety and a therapeutic agent are described herein. These compositions can be used for diagnosing and/or treating flaviviridae-family viruses including Zika virus, dengue virus, and yellow fever.Type: GrantFiled: October 10, 2017Date of Patent: May 18, 2021Assignee: Navidea Biopharmaceuticals, Inc.Inventors: Frederick O. Cope, David A. Ralph
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Patent number: 10997368Abstract: A method includes generating a plurality of entigen groups from a set of phrases of a statement and identifying two plausible entigen groups based on a true meaning interpretation of the statement. The method further includes identifying a related entigen group based on a phrase of the statement and interpreting each of the two plausible entigen groups in light of the related entigen group to determine whether one of the two plausible entigen groups is a more likely interpretation of the statement than the other one of the two plausible entigen groups. When the one of the two plausible entigen groups is the more likely interpretation of the statement, the method further includes updating the one of the two plausible entigen groups using the related entigen group to produce an updated entigen group and adding the statement as the updated entigen group to a knowledge database.Type: GrantFiled: March 21, 2019Date of Patent: May 4, 2021Assignee: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Donald Joseph Wurzel, Stephen Chen, Dennis Arlen Roberson, Andrew Chu, Gary W. Grube
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Patent number: 10943075Abstract: A method includes interpreting sets of first language identigens to produce an entigen group which represents a most likely meaning of a string of first language words. The method further includes identifying, for each entigen of the entigen group, a corresponding set of second language identigens to identify sets of second language identigens. The method further includes selecting, for each entigen of the entigen group, a selected second language identigen from the corresponding set of second language identigens based on meaning of the entigen to produce an initial string of second language words.Type: GrantFiled: January 25, 2019Date of Patent: March 9, 2021Assignee: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Gary W. Grube
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Patent number: 10942919Abstract: A method includes obtaining an initial answer entigen group from a knowledge database based on a query entigen group of a query. The method further includes determining that a reliable and definitive answer for the query is not obtainable from the initial answer entigen group. When an incomplete answer entigen is a cause for the inability to obtain the reliable and definitive answer, the method further includes determining a missing element, obtaining data regarding the missing element, updating the incomplete answer entigen with the data to produce an updated answer entigen, and updating the initial answer entigen group with the updated answer entigen to produce an updated answer entigen group. When the updated answer entigen group produces the reliable and definitive answer, the method further includes outputting the reliable and definitive answer.Type: GrantFiled: June 27, 2019Date of Patent: March 9, 2021Assignee: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Stephen Chen, Karl Olaf Knutson, Jessy Thomas, David Michael Corns, II, Andrew Chu, Gary W. Grube
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Publication number: 20210065936Abstract: Bundled cables and methods for preparing bundled cable are disclosed herein. In the method, a plurality of subunits is wound about a central member. The subunits include a subunit jacket made of a first thermoplastic composition and has a first outer surface, and the central member includes a central member jacket made of a second thermoplastic composition and has a second outer surface. A metal element is provided at an interface of the second outer surface and the first outer surface of the subunits. The metal element is heated such that at least one of the first thermoplastic composition or the second thermoplastic composition forms bonds with the other of the first thermoplastic composition or the second thermoplastic composition.Type: ApplicationFiled: August 11, 2020Publication date: March 4, 2021Inventors: David Ralph Maack, Lars Kristian Nielsen, James Arthur Register, III, William Taylor Rowell
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Publication number: 20210052639Abstract: Compositions and methods for ablating CD206 expressing macrophages and/or CD206 expressing myeloid derived suppressor cells (MDSCs) are disclosed. In certain aspects, disclosed methods comprise administering to a subject in need thereof an effective dose of a compound comprising a dextran backbone and one or more CD206 targeting moieties and one or more therapeutic agents attached thereto. In certain aspects, the therapeutic agent comprises a metal. In further aspects, the therapeutic agent comprises a cytotoxic agent.Type: ApplicationFiled: August 19, 2020Publication date: February 25, 2021Inventor: David A. Ralph
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Publication number: 20200342171Abstract: A method for execution by a computing device includes obtaining a phrase that includes string of words and generating a valid sequence of words utilizing the phrase. The method further includes identifying a set of identigens for each word of the valid sequence of words to produce sets of identigens. The method further includes identifying, for each identigen of the sets of identigens, a word type associated with phrase structure grammar rules to produce sets of identigen-type associations. The method further includes interpreting, utilizing the phrase structure grammar rules, the sets of identigen-type associations to produce an entigen group. The entigen group represents a most likely interpretation of the phrase.Type: ApplicationFiled: April 22, 2020Publication date: October 29, 2020Applicant: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Donald Joseph Wurzel, Stephen Emerson Sundberg, Ameeta Vasant Reed, Dennis Arlen Roberson, Thomas James MacTavish, Karl Olaf Knutson, Jessy Thomas, Niklas Josiah MacTavish, David Michael Corns, II, Andrew Chu, Theodore Mazurkiewicz, Gary W. Grube
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Publication number: 20200306381Abstract: Disclosed are methods and compositions for repolarizing a tumor associated macrophage (TAM) from M2 to M1 comprising administering to a subject in need thereof an effective dose of a compound comprising a dextran backbone and one or more CD206 targeting moieties conjugated thereto. In certain aspects, the compound further comprises a therapeutic agent selected from: paclitaxel, gemcitabine, lapatinib, and doxorubicin. In further aspect, the therapeutic agent comprises a chelator and at least one metal ion. In certain implementations, the at least one metal ion comprises at least one Cu(II) ions.Type: ApplicationFiled: March 27, 2020Publication date: October 1, 2020Inventor: David A. Ralph
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Publication number: 20200279175Abstract: A method performed by a computing device includes generating a comparative query entigen group set based on a comparative query in accordance with identigen rules, where the comparative query entigen group set represents a most likely interpretation of the comparative query. The method further includes obtaining a first response entigen group from a knowledge database based on a first comparative query entigen group of the comparative query entigen group set, where the first response entigen group substantially includes the first comparative query entigen group. The method further includes obtaining a second response entigen group from the knowledge database based on a second comparative query entigen group of the comparative query entigen group set, where the second response entigen group substantially includes the second comparative query entigen group. The method further includes generating a comparative response based on the first response entigen group and the second response entigen group.Type: ApplicationFiled: February 25, 2020Publication date: September 3, 2020Applicant: entigenlogic LLCInventors: Frank John Williams, David Ralph Lazzara, Stephen Emerson Sundberg, Ameeta Vasant Reed, Dennis Arlen Roberson, Thomas James MacTavish, Karl Olaf Knutson, Jessy Thomas, Niklas Josiah MacTavish, David Michael Corns, II, Andrew Chu, Theodore Mazurkiewicz, Gary W. Grube