Abstract: The present invention provides methods for treating and preventing cell proliferative disorders and conditions comprising administering to a subject resveratrol or an analog thereof.

Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

Abstract: Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin, such as SIRT1 or Sir2. Exemplary methods comprise contacting a cell or a molecule with a sirtuin inhibitory compound that decreases the activity of a sirtuin and thereby reduces the life span of a cell, kills the cell or renders it susceptible to certain cell stresses including radiation and chemotherapy. Other methods include treating pathogens expressing a sirtuin.

Abstract: Provided herein are compositions comprising agents that increase the level of expression of a sirtuin gene. Also provided are methods for purifying and isolating a factor from serum that stimulates the expression of a sirtuin gene. Diagnostic methods for determining whether a subject is calorically restricted or resistant to stress are also provided.

Abstract: Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.

Abstract: The invention pertains to an antifouling coating composition including 20-100% by weight, calculated on the total amount of film-forming components, of a film-forming polymer (A) having an acrylic backbone bearing at least one terminal group of the formula: wherein X represents M is a metal of Group Ib, IIa, IIb, IIIa, IIIb, IVa, IVb, Va, VIa, VIb, VIIa, and VIII of the Periodic Table with a valency of 2 or more and a degree of ionisation less than that of the alkali metals metal; n is an integer of 1 to 2; R represents an organic residue selected from and R1 is a monovalent organic residue, and 80-0% by weight, calculated of polymer (B) a copper-based biocide for aquatic organisms wherein the antifouling coating composition is substantially free of any biocidal zinc compounds and substantially free of rosin, and in that the copper-based biocide has a metallic copper content below 2% by weight, based on the total weight of the copper-based biocide.

Abstract: A network (10), such as a computer network, is disclosed. The network (10) has a plurality of nodes (20; 120) and includes a first node (30, 130) for storing pieces of a digital object and having a storage (40, 50; 140, 150). A plurality of connections are present between the first node (30, 130) and the plurality of nodes (20; 120). The first node (30, 130) has a requester for requesting one or more pieces of the digital object, a transmitter for transferring one or more pieces of the digital object to at least one further node among the plurality of nodes (20; 120), a receiver for receiving content availability messages from at least some of the plurality of nodes, and a sender for sending a limited content availability message to at least one further node (20; 120) among the plurality of nodes (20, 120). The limited content availability message indicates a subset but not all of the pieces of the digital object available through the first node (30; 130).

Abstract: The invention relates to a content distribution network for the distribution of a digital object in a peer-to-peer network with a plurality of peers having a peer location identifier and a download client (103a) for downloading the digital object. A of distributed caches (312a, 312b) is present in the peer-to-peer network. At least some of the plurality of peers (102a, 102b, 102c) are connected to at least some of the plurality of distributed caches (312). A private tracker for managing the distribution of the digital object among the plurality of distributed caches (312a, 312b) and a public tracker for managing the distribution of the digital object between the plurality of peers (102a, 102b, 102c) are present.

Abstract: A method for the distribution of digital objects (370) in a peer-to-peer network is disclosed. The digital objects (370) are distributed in a plurality of pieces (371-373). At least some of a plurality of peers (40a-d) are connected to other ones of the plurality of peers (40a-d) and at least one of the peers (40a-d) is connected to at least one cache (30).

Abstract: A method for selecting a preferred cache (312a) for the download of digital data from a plurality of caches (312; 312a-312d) is disclosed. The method comprises the steps of requesting an address of the preferred cache (312a) and selecting the preferred cache (312a) from the plurality of caches (312a). The selection of the preferred cache (312a) is derived from a location identifier of a client (102) requesting the download of the digital data.

Abstract: A network and method for the delivery of digital data is disclosed having at least one peer (102a) downloading the digital data from a plurality of data sources (102, 312), at least one data monitoring device (800) for monitoring at least one quality of service parameter for the delivery of the digital data and at least one data delivery controller (810) for adjusting at least one of the rates for the delivery of the digital data from at least one of the plurality of data sources (102, 312).

Abstract: This invention relates to a method, system and computer program product for reading data from a storage controller in storage area network. A read data instruction is received from an application requesting data from the storage controller using a primary data path. If the data on the primary data path is not transferred in a defined time interval using the primary data path, data is requested from the storage controller using one or more alternative data paths. Data is received from the storage controller on one of data paths and into a buffer. When the read instruction has completed and that the data is in the buffer, the application is notified. Each data path is associated with a buffer and the data is received into a buffer associated with the path. The application is informed which buffer holds the data and the application accesses the data from this buffer.

Abstract: A technique is provided for classifying images in a library (1) for subsequent selective retrieval. Each library image is segmented (2) into a plurality of coherent regions. Each of the regions is analysed in respect of a plurality of visual properties, each of which is ascribed a number according to the value of the visual property. The property numbers are then compared (4) with bands of the available property range and a computer-readable character, such as a letter of the alphabet, is ascribed to each of the property values. The characters are then arranged (5) in a predetermined order to form a region character string. The strings for each region are then indexed (7) to form an index (8) of the images by region character string. For image retrieval, a target image (10) is analysed in the same way to form region character strings which are then supplied to a text retrieval system (12) for detecting matches with entries in the index (8).

Abstract: Provided herein are methods and compositions for treating and/or preventing flushing and/or weight gain. Methods may comprise modulating the activity or level of a sirtuin, such as SIRT1 or Sir2. Exemplary embodiments include methods and compositions for counteracting drug-induced weight gain and/or drug-induced flushing by administering a sirtuin-activating compound.

Abstract: Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: Provided herein are methods and compositions for modulating apoptosis of cells and the lifespan of cells. These may be used for treating or preventing aging-related disorders and cancer.

Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease.

Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Abstract: Monolayer packages comprised of an oxygen scavenging composition suitable for direct contact with package contents and recycle with other polyester bottles are disclosed. The oxygen scavenging composition is comprised of a modified copolymer which is comprised of predominantly polyester segments and an oxygen scavenging amount of oxygen scavenging segments. The polyester segments comprise segments derived from typical bottling and packaging polyesters such as PET and PEN. Use of these oxygen scavenging copolymers in bottles provides a clear and rigid monolayer bottle similar in appearance to unmodified polyester bottles. In a series of preferred embodiments, bottles fabricated with the oxygen scavenging copolymers of this invention are over 99 wt % PET and contain less than 50 ppb of extractable components.