Abstract: A method for selecting a preferred cache for the download of digital data from a plurality of caches is disclosed. The method comprises the steps of requesting an address of the preferred cache and selecting the preferred cache from the plurality of caches. The selection of the preferred cache is derived from a location identifier of a client requesting the download of the digital data.

Abstract: The invention relates to methods and kits for measuring enzyme activity, including enzymes that produce nicotinamide.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Abstract: The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: A method for the distribution of digital objects in a peer-to-peer network is disclosed. The digital objects are distributed in a plurality of pieces. At least some of a plurality of peers are connected to other ones of the plurality of peers and at least one of the peers is connected to at least one cache.

Abstract: A network and method for the delivery of digital data is disclosed having at least one peer (102a) downloading the digital data from a plurality of data sources (102, 312), at least one data monitoring device (800) for monitoring at least one quality of service parameter for the delivery of the digital data and at least one data delivery controller (810) for adjusting at least one of the rates for the delivery of the digital data from at least one of the plurality of data sources (102, 312).

Abstract: The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Abstract: A spherical object is disclosed provided with a map substantial covering its entire surface wherein the map represents only a portion of the Earth such as a town, city, district, county, state or country. A label is also disclosed provided comprising a series of biconvex shapes which collectively describe such a map.

Abstract: The invention relates to modulation of SIRT3 activity levels. The invention has applications for regulating metabolism and mimicking caloric restriction or exercise in a muscle cell.

Abstract: A method for treating eating disorders by repeatedly administering naloxone in a dosage sufficient to block the effects of opiate agonists to a subject suffering from an eating disorder caused by one or more related problem responses; while the amount of naloxone in the subject's body is sufficient to block opiate effects, having the subject make one of the problem responses from which the subject suffers in the presence of stimuli similar to those to which it had been learned, after the amount of naloxone is no longer sufficient to block opiate effects, having the subject make healthy eating responses to food items that do not trigger the problem responses; and continuing the steps of administration of naloxone and having one after another of the problem responses made, followed by having a naloxone-free period in which healthy eating occurs, until the problem responses are extinguished.

Abstract: Provided herein are methods and compositions relating to sirtuin modulation of Wnt pathway signaling, including the use of sirtuin and sirtuin-modulating agents in the prevention and treatment of cancer and other diseases.

Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

Abstract: The present invention provides methods and compositions for improving the health of subjects, such as their resistance to stress.

Abstract: This invention relates to a method, system and computer program product for reading data from a storage controller in storage area network. A read data instruction is received from an application requesting data from the storage controller using a primary data path. If the data on the primary data path is not transferred in a defined time interval using the primary data path, data is requested from the storage controller using one or more alternative data paths. Data is received from the storage controller on one of data paths and into a buffer. When the read instruction has completed and that the data is in the buffer, the application is notified. Each data path is associated with a buffer and the data is received into a buffer associated with the path. The application is informed which buffer holds the data and the application accesses the data from this buffer.

Abstract: The determination of wax crystal particle size and population is used to monitor the performance of wax crystallizers used in lubricant oil processing using solvent dewaxing. The wax crystal particle size is monitored using online measurements. The information obtained from on-line monitoring is then used to control crystallization in the dewaxing equipment in order to optimize performance of the dewaxing units.

Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.