Patents by Inventor David Sinclair

David Sinclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells
    Publication number: 20160024527
    Abstract: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 28, 2016
    Inventors: Jonathan Lee Tilly, David A Sinclair
  • Cognitive performance with sirtuin activators
    Patent number: 9241916
    Abstract: Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: January 26, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Li-Huei Tsai, Andre Fischer
  • Storage performance
    Patent number: 9241032
    Abstract: A network, such as a computer network, is disclosed. The network has a plurality of nodes and includes a first node for storing pieces of a digital object and having a storage. A plurality of connections are present between the first node and the plurality of nodes. The first node has a requester for requesting one or more pieces of the digital object, a transmitter for transferring one or more pieces of the digital object to at least one further node among the plurality of nodes, a receiver for receiving content availability messages from at least some of the plurality of nodes, and a sender for sending a limited content availability message to at least one further node among the plurality of nodes. The limited content availability message indicates a subset but not all of the pieces of the digital object available through the first node.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: January 19, 2016
    Assignee: Alcatel Lucent
    Inventors: John Sullivan, David Sinclair Ferguson, Jarrod Lowe
  • NAD BIOSYNTHESIS AND PRECURSORS FOR THE TREATMENT AND PREVENTION OF CANCER AND PROLIFERATION
    Publication number: 20150313930
    Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
    Type: Application
    Filed: October 9, 2013
    Publication date: November 5, 2015
    Inventors: David A. Sinclair, Ana P. Gomes
  • TREATMENT OF AGE-RELATED AND MITOCHONDRIAL DISEASES BY INHIBITION OF HIF-1 ALPHA FUNCTION
    Publication number: 20150266946
    Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction.
    Type: Application
    Filed: October 9, 2013
    Publication date: September 24, 2015
    Inventors: David A. Sinclair, Ana P. Gomes, Eric Bell
  • NAD BIOSYNTHESIS AND PRECURSORS IN THE PREVENTION AND TREATMENT OF INFLAMMATION
    Publication number: 20150265642
    Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of disorders associated with inflammation by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
    Type: Application
    Filed: October 9, 2013
    Publication date: September 24, 2015
    Inventors: David A. Sinclair, Ana P. Gomes
  • DETECTION AND MODULATION OF CYTOCHROME C ACETYLATION
    Publication number: 20150233949
    Abstract: The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.
    Type: Application
    Filed: January 16, 2015
    Publication date: August 20, 2015
    Inventors: ANGELA VALESKA HAFNER, DAVID A. SINCLAIR
  • NICOTINAMIDE RIBOSIDE AND ANALOGUES THEREOF
    Publication number: 20150175645
    Abstract: Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
    Type: Application
    Filed: July 24, 2014
    Publication date: June 25, 2015
    Inventors: Michael MILBURN, Jill MILNE, Karl D. NORMINGTON, Joseph J. NUNES, Thomas SALZMANN, David SINCLAIR, Christoph H. WESTPHAL
  • COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
    Publication number: 20150133396
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Application
    Filed: August 15, 2014
    Publication date: May 14, 2015
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • STORAGE INTEGRITY VALIDATOR
    Publication number: 20140359399
    Abstract: This disclosure relates to validating data written to logical blocks on a storage subsystem adapted so that during write operations an additional sequence code is written to each logical block of data, where the sequence code remains constant for each write operation batch and where the sequence code is incremented for each new write operation batch. A sequence code verification system may comprise a data reader, a validity engine, and an error notifier. The data reader may read sequence codes from consecutive logical blocks. The validity engine may invalidate write operations in response to checking data validity by applying comparison operations to sequence codes and block offsets of batch write operations. The error notifier may notify a user of an error for each invalidated write operation batch.
    Type: Application
    Filed: April 22, 2014
    Publication date: December 4, 2014
    Applicant: International Business Machines Corporation
    Inventors: Huw Francis, David A. Sinclair
  • Compositions for treating obesity and insulin resistance disorders
    Patent number: 8846724
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 30, 2014
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Small Molecule CD38 Inhibitors and Methods of Using Same
    Publication number: 20140221319
    Abstract: The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
    Type: Application
    Filed: April 13, 2012
    Publication date: August 7, 2014
    Applicants: Mayo Foundation for Medical Education and Research, President and Fellows of Harvard College
    Inventors: David A. Sinclair, Nathan L. Price, Eduardo N. Chini, Jon C. Clardy, Shugeng Cao
  • BIOCIDAL FOUL RELEASE COATING SYSTEMS
    Publication number: 20140141263
    Abstract: Structure coated with a biocidal foul release coating system, the structure being obtained by a. providing a substrate, b. coating the substrate with a first coating layer, c. applying at least one subsequent coating layer on top of the first coating layer, the first coating layer containing a biocide, the subsequent coating layer(s) containing less biocide than the first coating layer and which is(are)free or substantially free of biocide, and wherein the first and the subsequent coating layer(s) form a biocidal foul release coating system showing a controlled leaching of the biocide.
    Type: Application
    Filed: July 19, 2012
    Publication date: May 22, 2014
    Applicant: AKZO NOBEL COATINGS INTERNATIONAL B.V.
    Inventors: Phillip Keith Jones, Ian Michael Hawkins, Andrew Curry, Zhiyi Li, John David Sinclair-Day
  • Cost effective use of simulated storage in a storage subsystem test environment
    Patent number: 8719635
    Abstract: A data receiver module receives, at a storage device simulator, a data transmission from a storage controller being tested. The data transmission includes data and metadata. The metadata is associated with the data. A signature receiver module receives a signature from the storage controller as part of the data transmission. The signature is used to distinguish the metadata from the data. A data/metadata determination module examines the data transmission and determines data from metadata using the signature. A metadata storage module stores the metadata of the data transmission on the storage device simulator in response to the data transmission including metadata. The data storage simulator includes a data storage device. A data discard module discards the data of the data transmission in response to the data transmission including data.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: May 6, 2014
    Assignee: International Business Machines Corporation
    Inventors: Denis A. Frank, Payal Mehta, David A. Sinclair
  • SYSTEMS AND METHODS FOR FACILITATING DIAGNOSIS AND PRODUCT IDENTIFICATION FOR PATIENTS REQUIRING CONTINENCE PRODUCTS
    Publication number: 20140067856
    Abstract: Systems and methods for facilitating diagnosis and product identification for patients requiring continence products. Embodiments of the invention have been particularly developed there by to provide a software application (for example an iOS or Android application) thereby to assist a clinician and/or patient in identifying appropriate continence products for a given set of patient requirements. While some embodiments will be described herein with particular reference to that application, it will be appreciated that the invention is not limited to such a field of use, and is applicable in broader contexts.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 6, 2014
    Inventors: Kylie Wicks, David Sinclair, Birgitte Maibom, Elke Krishnan
  • DENTAL IMPLANT
    Publication number: 20130273498
    Abstract: A dental implant comprising an implant body which has an asymmetric root portion receivable in an asymmetric open root cavity of the patient and engagement means on the asymmetric root portion to at least in part engage a surface of the root cavity so as to prevent or inhibit unintentional extraction. The asymmetric root portion is complementarily shaped to fit the said asymmetric open root cavity, thus substantially dispensing with the need for protracted preparation of the root cavity and providing substantially immediate stability for the prosthetic tooth.
    Type: Application
    Filed: November 1, 2011
    Publication date: October 17, 2013
    Inventors: John Woods, Michael Tuke, David Sinclair
  • Cost effective use of simulated storage in a storage subsystem test environment
    Publication number: 20130179733
    Abstract: A data receiver module receives, at a storage device simulator, a data transmission from a storage controller being tested. The data transmission includes data and metadata. The metadata is associated with the data. A signature receiver module receives a signature from the storage controller as part of the data transmission. The signature is used to distinguish the metadata from the data. A data/metadata determination module examines the data transmission and determines data from metadata using the signature. A metadata storage module stores the metadata of the data transmission on the storage device simulator in response to the data transmission including metadata. The data storage simulator includes a data storage device. A data discard module discards the data of the data transmission in response to the data transmission including data.
    Type: Application
    Filed: January 6, 2012
    Publication date: July 11, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Denis A. Frank, Payal Mehta, David A. Sinclair
  • COMPOSITIONS AND METHODS FOR ENHANCING BIOENERGETIC STATUS IN FEMALE GERM CELLS
    Publication number: 20130059384
    Abstract: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
    Type: Application
    Filed: April 13, 2012
    Publication date: March 7, 2013
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: JONATHAN L. TILLY, DAVID A. SINCLAIR
  • Method for reducing the weight of a subject or inhibiting weight gain in a subject
    Patent number: 8242171
    Abstract: Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: August 14, 2012
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David A. Sinclair, Maria Alexander-Bridges
  • Globe
    Patent number: D683792
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: June 4, 2013
    Assignee: Globee Limited
    Inventor: David Sinclair