Patents by Inventor David Spencer

David Spencer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VIDEO AND ACCESSORY APPARATUS FOR A VIDEOFLUOROSCOPY UNIT
    Publication number: 20180078225
    Abstract: A videofluoroscopy device with a video and data management system. More particularly, it relates to a videofluoroscopy accessory device adapted to securely and removably attach to an X-ray head of a fluoroscopy system or device, and systems to manage the operation of the videofluoroscopy accessory device.
    Type: Application
    Filed: September 18, 2017
    Publication date: March 22, 2018
    Inventor: Jon David Spencer
  • Methods for inducing partial apoptosis using caspase polypeptides
    Patent number: 9913882
    Abstract: The technology relates in part to methods for inducing partial apoptosis of cells that express an inducible caspase polypeptide. The technology further relates in part to methods for inducing partial apoptosis of cells that express an inducible modified caspase polypeptide, having a modified dose response curve to the multimeric ligand inducer. The technology also relates in part to methods for cell therapy using cells that express the inducible caspase polypeptide or the inducible modified caspase polypeptide, where the proportion of caspase polypeptide-expressing cells eliminated by apoptosis is related to the administered amount of the multimeric ligand inducer.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: March 13, 2018
    Assignee: Bellicum Pharmaceuticals, Inc.
    Inventors: Kevin Slawin, David Spencer, Aaron Edward Foster
  • Adaptive model-based method to quantify degradation of a power generation system
    Patent number: 9896960
    Abstract: A system includes a power generation system and a controller that controls the power generation system. The controller includes a processor that generates a model of the power generation system that estimates a value for a first parameter of the power generation system. The processor also receives a measured value of the first parameter. The processor further adjusts a correction factor of the model such that the estimated value of the first parameter output by the model is approximately equal to the measured value of the first parameter. The processor also generates a transfer function that represents the correction factor as a function of a second parameter of the power generation system. The processor further displays the transfer function along with one or more previously generated transfer functions to quantify degradation of the power generation system.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: February 20, 2018
    Assignee: General Electric Company
    Inventors: David Spencer Ewens, Frederick William Block, William Forrester Seely
  • ADAPTIVE MODEL-BASED METHOD TO QUANTIFY DEGRADATION OF A POWER GENERATION SYSTEM
    Publication number: 20170350271
    Abstract: A system includes a power generation system and a controller that controls the power generation system. The controller includes a processor that generates a model of the power generation system that estimates a value for a first parameter of the power generation system. The processor also receives a measured value of the first parameter. The processor further adjusts a correction factor of the model such that the estimated value of the first parameter output by the model is approximately equal to the measured value of the first parameter. The processor also generates a transfer function that represents the correction factor as a function of a second parameter of the power generation system. The processor further displays the transfer function along with one or more previously generated transfer functions to quantify degradation of the power generation system.
    Type: Application
    Filed: June 7, 2016
    Publication date: December 7, 2017
    Inventors: David Spencer Ewens, Frederick William Block, William Forrester Seely
  • Probabilistic control in gas turbine tuning for power output-emissions parameters, related control systems, computer program products and methods
    Patent number: 9797315
    Abstract: Various embodiments include a system having: at least one computing device configured to tune a set of gas turbines (GTs) by performing actions including: commanding each GT in the set of GTs to a base load level, based upon a measured ambient condition for each GT; commanding each GT in the set of GTs to adjust a respective power output to match a nominal power output value, and subsequently measuring an actual emissions value for each GT; adjusting an operating condition of each GT in the set of GTs based upon a difference between the respective measured actual emissions value and a nominal emissions value at the ambient condition; and setting a target operating condition for each GT to match the adjusted operating condition after the adjusting of the operating condition.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: October 24, 2017
    Assignee: General Electric Company
    Inventors: Harold Lamar Jordan, Jr., Lewis Berkley Davis, Jr., Scott Arthur Day, David Spencer Ewens, Rex Allen Morgan
  • Method and system for gas turbine power augmentation using steam injection
    Patent number: 9732672
    Abstract: A method of augmenting power output by a gas turbine engine includes channeling fuel into the gas turbine engine at a predetermined fuel flow rate to generate a first power output. Steam is then injected into the gas turbine engine at a first steam flow rate, and a firing temperature bias is determined based at least on the first steam flow rate. The predetermined fuel flow rate is then adjusted based on the determined firing temperature bias such that the gas turbine engine generates a second power output greater than the first power output.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: August 15, 2017
    Assignee: General Electric Company
    Inventors: David Spencer Ewens, Michael Corey Mullen, Bhushan Meshram
  • INDUCED ACTIVATION IN DENDRITIC CELLS
    Publication number: 20170182140
    Abstract: The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.
    Type: Application
    Filed: January 5, 2017
    Publication date: June 29, 2017
    Inventors: David SPENCER, Brent HANKS, Kevin SLAWIN
  • PROBABILISTIC CONTROL IN GAS TURBINE TUNING FOR POWER OUTPUT-EMISSIONS PARAMETERS, RELATED CONTROL SYSTEMS, COMPUTER PROGRAM PRODUCTS AND METHODS
    Publication number: 20170175648
    Abstract: Various embodiments include a system having: at least one computing device configured to tune a set of gas turbines (GTs) by performing actions including: commanding each GT in the set of GTs to a base load level, based upon a measured ambient condition for each GT; commanding each GT in the set of GTs to adjust a respective power output to match a nominal power output value, and subsequently measuring an actual emissions value for each GT; adjusting an operating condition of each GT in the set of GTs based upon a difference between the respective measured actual emissions value and a nominal emissions value at the ambient condition; and setting a target operating condition for each GT to match the adjusted operating condition after the adjusting of the operating condition.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 22, 2017
    Inventors: Harold Lamar Jordan, JR., Lewis Berkley Davis, JR., Scott Arthur Day, David Spencer Ewens, Rex Allen Morgan
  • Receiver scheduling in wireless networks
    Patent number: 9674858
    Abstract: A wireless apparatus may receive scheduling definitions from a networking device. The wireless apparatus may determine, from the scheduling definitions, downlink transmission times and to start a timer at one of the determined downlink transmission times. The wireless apparatus may discontinue reception at expiration of the timer. The wireless apparatus may also, in response to reception of a downlink transmission, transmit an acknowledgement and to discontinue reception before the timer has expired.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: June 6, 2017
    Assignee: III Holdings 1, LLC
    Inventors: Brig Barnum Elliott, David Spencer Pearson
  • Method and system for combustion mode transfer for a gas turbine engine
    Patent number: 9639071
    Abstract: A method and system for transferring between combustion modes in a gas turbine engine is provided. A processor generates data representative of an initial set of splits for providing at least one of fuel and air to at least one combustor in the gas turbine engine. A gas turbine engine model module generates data representative of at least one engine operating condition. A first split calculation module generates data representative of at least one set of active control splits to control the engine in a first combustion mode, using as an input the initial split data. A second split calculation module generates data representative of at least one set of passive control splits to control the engine in at least a second combustion mode. Transfer between combustion modes may be accomplished via use of at least one of the active control splits and the passive control splits.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: May 2, 2017
    Assignee: General Electric Company
    Inventors: Prabhanjana Kalya, Steven William Backman, Laura Lea Boes, David Spencer Ewens, Trevor Valder Jones
  • Wash timing based on turbine operating parameters
    Patent number: 9605559
    Abstract: A system may include a memory storing a turbomachinery degradation model configured to model degradation of a turbine system over time. Further, the system may include a controller communicatively coupled to the memory, which derives a turbomachinery wash timing based on at least one input signal from the turbine system and the turbomachinery degradation model. The turbomachinery degradation model may derive a desired wash point by estimating a modeled power of the turbine system, a modeled heat rate of the turbine system, or both. Furthermore, the controller may use the desired wash point to determine a time for washing components of the turbine system.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: March 28, 2017
    Assignee: General Electric Company
    Inventors: Alan Meier Truesdale, David Spencer Ewens, Sidharth Abrol
  • Induced activation in dendritic cells
    Patent number: 9572835
    Abstract: The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: February 21, 2017
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: David Spencer, Brent Hanks, Kevin Slawin
  • MODIFIED CASPASE POLYPEPTIDES AND USES THEREOF
    Publication number: 20170015987
    Abstract: The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.
    Type: Application
    Filed: July 29, 2016
    Publication date: January 19, 2017
    Inventors: David SPENCER, Wei-Chun Chang
  • METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS
    Publication number: 20170002321
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
    Type: Application
    Filed: July 21, 2016
    Publication date: January 5, 2017
    Inventors: David SPENCER, Priyadharshini Narayanan
  • Drug Delivery Inhaler Devices
    Publication number: 20160354565
    Abstract: An adapter for fitting to a drug delivery device, the adapter including: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of said drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. A drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 8, 2016
    Inventors: Ronald Bruin, David Spencer, Mark Sanders
  • Modified caspase polypeptides and uses thereof
    Patent number: 9434935
    Abstract: The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.
    Type: Grant
    Filed: March 10, 2013
    Date of Patent: September 6, 2016
    Assignee: BELLICUM PHARMACEUTICALS, INC.
    Inventors: David Spencer, Wei-Chun Chang
  • Drug delivery inhaler devices
    Patent number: 9427534
    Abstract: The present invention provides an adapter for fitting to a drug delivery device, the adapter comprising: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of the drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. The present invention also provides a drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 30, 2016
    Assignee: Clement Clarke International Ltd.
    Inventors: Ronald Bruin, David Spencer, Mark Sanders
  • Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
    Patent number: 9428569
    Abstract: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: August 30, 2016
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: David Spencer, Priyadharshini Narayanan
  • Spacer for inhaler
    Patent number: D778432
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: February 7, 2017
    Assignee: Clement Clarke International Limited
    Inventors: Mark Sanders, David Spencer, Ronald Bruin
  • Spacer for inhaler
    Patent number: D797922
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: September 19, 2017
    Assignee: Clement Clarke International Limited
    Inventors: Mark Sanders, David Spencer, Ronald Bruin