Abstract: Methods and systems for modeling turbine operation are disclosed. In one embodiment a method for modeling turbine operation may include: determining current performance parameters of a turbine; providing at least one external factor for current or future operation of the turbine; and modeling, by a predictive model, at least one operating characteristic of the turbine based at least in part on the current performance parameters of the turbine and the at least one external factor.

Abstract: Provided herein are methods for treating a solid tumor in a subject in need thereof by activating an immune response against a tumor antigen. Also provided are methods for treating a solid tumor in a subject in need thereof by activating antigen-presenting cells and eliciting an immune response against a tumor antigen. Also provided herein are optimized therapeutic treatments of solid tumors, which comprise determining the presence, absence or amount of a biomarker after the therapy has been administered, and determining whether a subsequent dose of the therapy should be maintained, increased, or decreased based on the biomarker assessment.

Abstract: The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Abstract: A machine-actionable memory comprises one or more machine-actionable records arranged according to a data structure. Such a data structure may include links that respectively map between: a RID field, the contents of which denote an identification (ID) of a remediation (RID); at least one TID field, the contents of which denotes an ID of at least two technologies (TIDs), respectively; and at least one ACTID field, the contents of which denotes an ID of an action (ACTID). A method, of selecting a remediation that is appropriate to a technology present on a machine to be remediated, may include: providing such a machine-actionable memory; and indexing into the memory using a given RID value and a given TID value to determine values of the at-least-one ACTID corresponding to the given RID value and appropriate to the given TID value.

Abstract: An adapter for fitting to a drug delivery device, the adapter including: an outlet for communication with the mouth of a patient; an air flow path through the adapter along which air is drawn to the outlet by inhalation by the patient; an inlet adapted for connection to a mouthpiece of said drug delivery device; and an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient. A drug delivery device having, in its body, an air flow rate indicator operable to indicate when the air flow rate along the air flow path is at or above a predetermined minimum level suitable for delivery of the drug to the patient.

Abstract: A machine-actionable memory comprises one or more machine-actionable records arranged according to a data structure. Such a data structure may include links that respectively map between a remediation, at least one action, and at least two vulnerabilities. A method of selecting a remediation, that is appropriate to a vulnerability which is present on a machine to be remediated, may include: providing a machine-actionable memory as mentioned above; and indexing into the memory using: a given vulnerability identifier to determine (A) at least one of a remediation mapped thereto and (B) at least one action mapped to the given vulnerability identifier; and/or a given remediation to determine at least two vulnerabilities mapped thereto.

Abstract: A machine-actionable memory comprises one or more machine-actionable records arranged according to a data structure. Such a data structure may include links that respectively map between a remediation, at least one action, and at least two vulnerabilities. A method of selecting a remediation, that is appropriate to a vulnerability which is present on a machine to be remediated, may include: providing a machine-actionable memory as mentioned above; and indexing into the memory using: a given vulnerability identifier to determine (A) at least one of a remediation mapped thereto and (B) at least one action mapped to the given vulnerability identifier; and/or a given remediation to determine at least two vulnerabilities mapped thereto.

Abstract: In some embodiments, a mobile device includes an interface configured to scan information from a communication tag associated with an asset, a memory operable to store the information, and a processor communicatively coupled to the memory. The information comprises a header describing the information, business application data, and asset identification data uniquely identifying the asset. The processor is configured to extract the business application data from the information scanned from the communication tag and extract the asset identification data from the information scanned from the communication tag.

Abstract: Modified antigen presenting cells provided herein have improved lifespan and immunogenicity compared to unmodified antigen presenting cells, and are useful for immunotherapy. The modified antigen presenting cells express an altered protein kinase, referred to herein as “Akt.” The altered Akt associates with the cell membrane with greater frequency than unaltered Akt, and is referred to herein as “membrane-targeted Akt.

Abstract: A security device may receive information relating to a security event in a customer network. The security device may further determine, in response to receiving the information, a likelihood score that reflects a likelihood that the security event will succeed and an impact score that provides an indication of an impact that the security event will have on the customer network. The security device may also determine a risk score based on the likelihood score and the impact score, where the risk score provides an indication of a risk that the security event will affect the customer network. The security device may provide the risk score to a customer associated with the customer network.

Abstract: Modified antigen presenting cells provided herein have improved lifespan and immunogenicity compared to unmodified antigen presenting cells, and are useful for immunotherapy. The modified antigen presenting cells express an altered protein kinase, referred to herein as “Akt.” The altered Akt associates with the cell membrane with greater frequency than unaltered Akt, and is referred to herein as “membrane-targeted Akt.

Abstract: A shingle insert and method for eliminating and preventing growths on a shingled roof in which a porous copper mesh is installed with an upper edge beneath a course of shingles with the remaining portions of the insert exposed. A confined space is defined beneath a lengthwise hump in the exposed copper strip portions which is filled with a growth toxic material, in solid or granular form which releases a substance toxic to the growths when rainwater runoff passes into the confined space and material and thereafter flows out down the roof.

Abstract: An auto-regulated motion power system apparatus that may be used to generate usable electricity from disparate energy sources includes a combination of a variable frequency alternator driven by a primary mover and coupled to a load. An energy control module includes a closed-loop feedback system coupled to a pulse width modulation controller and a switch mode rectifier. The alternator has a modulated control signal input having the ability to vary in frequency and voltage with an output having a controlled voltage and varying frequency. The switch mode rectifier accepts variable AC voltages from the alternator and outputs a constant predetermined DC voltage both to one side of the windings of the alternator and to a first side of a high frequency switch. An output on the pulse width modulation generator is connected to a switch control so that when the switch is closed, current flows through the windings of the alternator and when the switch is open, no current flows through the windings.

Abstract: An extension ladder stabilizer includes a ladder rung engagement rod having threads along at least a portion of its length and configured to be disposed in and project from each end of a hollow tubular rung of an extension ladder, a pair of internal supports having a substantially gear shaped hole in each, a pair of external supports having a substantially gear shaped boss with a through hole on a first face and an anchor channel on a second face opposite the first face on each, and a pair of ground engagement members. In a ladder stabilizing configuration, the extension ladder stabilizer is installed on a ladder and the ground engagement members are passed through the anchor channels and into the ground to secure the ladder from side slipping, kicking back, and kicking over when in use.

Abstract: An apparatus and method for operably connecting a first person to a second person. The apparatus comprises a wrist strap having first and second ends sized to closely extend around a wrist of a first person and a coupling formed of a first coupling half located at the first end and a second coupling half located at the second end. The first and second coupling ends are lockably engageable with each other. The coupling has a pair of buttons to opposed sides thereof wherein the pair of buttons cooperate to disengage the second coupling half from the first coupling half and a connector extending from the wrist strap member connectable to a second person. The method comprises lockably and closely securing the wrist strap to a wrist of the first person, and securing a connector extending from the first wrist strap to a second user.

Abstract: A shingle insert strip and method for eliminating and preventing growths on a shingled roof in which porous copper strips are installed with upper edges beneath the bottom edges course of shingles with the remaining portions exposed. A confined space is defined beneath a lengthwise hump in the exposed portions which is filled with a material, preferably in granular form which releases a substance toxic to the growths when rainwater runoff passes into the confined space and material and thereafter flows out.

Abstract: A machine-actionable memory comprises one or more machine-actionable records arranged according to a data structure. Such a data structure may include links that respectively map between: a RID field, the contents of which denote an identification (ID) of a remediation (RID); at least one TID field, the contents of which denotes an ID of at least two technologies (TIDs), respectively; and at least one ACTID field, the contents of which denotes an ID of an action (ACTID). A method, of selecting a remediation that is appropriate to a technology present on a machine to be remediated, may include: providing such a machine-actionable memory; and indexing into the memory using a given RID value and a given TID value to determine values of the at-least-one ACTID corresponding to the given RID value and appropriate to the given TID value.

Abstract: A coordinated air-fuel controller and associated method provide a fuel controller, a combustion air controller and a steady-state air versus fuel model. The fuel controller generates a fuel control output signal and the combustion air controller generates a combustion air control output signal. The fuel controller determines a preliminary fuel control signal based on at least one of first and second loop control signals, and determines the fuel control output signal based on the preliminary fuel control signal. The steady-state air versus fuel model processes the preliminary fuel control signal to determine an expected steady-state combustion air control signal. The combustion air controller determines a preliminary combustion air control signal based on at least one of a third loop control signal and a fourth loop control signal, and determines the combustion air control output signal based on the preliminary combustion air control signal and the expected steady-state combustion air control signal.

Abstract: A machine-actionable memory comprises one or more machine-actionable records arranged according to a data structure. Such a data structure may include links that respectively map between: a RID field, the contents of which denote an identification (ID) of a remediation (RID); at least one TID field, the contents of which denotes an ID of at least two technologies (TIDs), respectively; and at least one ACTID field, the contents of which denotes an ID of an action (ACTID). A method, of selecting a remediation that is appropriate to a technology present on a machine to be remediated, may include: providing such a machine-actionable memory; and indexing into the memory using a given RID value and a given TID value to determine values of the at-least-one ACTID corresponding to the given RID value and appropriate to the given TID value.