Abstract: A clot retrieval device for removing clot from a blood vessel including a plurality of ring elements comprising a plurality of struts forming one or more closed cells having one or more crown elements and attached together by connecting tethers at connection points, a plurality of openings through which clot may pass and enter the device, each opening being disposed between respective ring elements. Each ring element can be self-expandable from a collapsed configuration to an expanded configuration wherein a radial force biases the ring elements toward the expanded configuration. At least one of the crown element terminates in an apex away from a center axis of the device.

Abstract: The designs and methods disclosed herein are for a clot retrieval catheter that can have a proximal elongate body with a large bore lumen and a distal tip expandable to a diameter larger than the outer sheath through which it is delivered. The distal tip can have a flexible metallic support frame to provide radial scaffolding and the ability for further flexible expansion when ingesting a clot. The support frame can be designed so that the expanding movement is focused in a portion of the circumference though a plurality of deformable cells that can collapse to be almost flat and parallel to the longitudinal axis for deliverability, but expand to a very steep angle for good resistance to collapse under aspiration. The designs can be sufficiently flexible to navigate tortuous anatomy but recover to maintain the inner diameter of the lumen when displaced in a vessel.

Abstract: An access guidewire has a distal portion including a distal portion length and a distal portion diameter. The guidewire also includes an intermediate portion, proximal to the distal portion, having an intermediate portion length and an intermediate portion diameter. A proximal portion is proximal of the intermediate portion and includes a proximal portion length and a proximal portion diameter. The intermediate portion diameter is greater than the the distal portion diameter and the proximal portion diameter.

Abstract: A clot retrieval device comprising an elongate shaft having a proximal end and a distal end and a clot retrieval element at the distal end of the elongate shaft. A proximal end of the elongate shaft configured to retract a first catheter over the elongate shaft. The shaft extension member comprising one or more raised profiles configured to interfere with one or more indentations along the elongate shaft such that the shaft extension member is configured to extend between a first length and an intermediate length. A second catheter is advanced to or adjacent to the distal end of the clot retrieval device shaft to enable enhanced aspiration adjacent to the clot retrieval element.

Abstract: Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel. Use of the clot retrieval device reducing in-hospital mortality.

Abstract: Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel. Use of the clot retrieval device reducing in-hospital mortality.

Abstract: A clot removal device that includes an expandable structure comprising interconnected struts configured to engage with clot. The interconnected struts are configured in the expanded clot engaging deployed configuration so at least a portion of the plurality of interconnected struts interpenetrates clot. The expandable structure includes a distal section, a proximal pinch section proximal of the distal section, and a clot capture mechanism.

Abstract: A clot capture catheter having an outer inflatable expansile member and an inner inflatable expansile member positioned within the outer inflatable expansile member at a distal end of a shaft of the catheter is presented herein. The inner and outer inflatable expansile members can have differing compliance than each other. Inflation of a higher compliance inner inflatable expansile member can cause a lower compliance outer inflatable expansile member to shorten and provide tension to the distal end of the shaft to case the distal end to open to a funnel shape. Inflation of a lower compliance inner inflatable expansile member can center the distal end of the shaft within a vessel, and inflation of a higher compliance outer inflatable member can provide atraumatic flow arrest to the vessel.

Abstract: Example systems and methods of treatment are presented herein which generally involve expanding a bracing frame within a blood vessel between a clot and an aspiration catheter, aspirating the clot through a passageway of the bracing frame, and supporting the blood vessel by the bracing frame as negative pressure is created by the aspiration. The bracing frame can thereby reduce likelihood of blood vessel collapse compared to a similar procedure which does not include the bracing frame. The bracing frame can be removed from the blood vessel during treatment. In some examples, the bracing frame can further function to expand a mouth of the catheter. In some examples, the system can include a stentriever.

Abstract: A cerebral vessel access device having a base tube comprising an inner lumen, a shapeable element disposed to one side of the base tube, and an outer jacket covering the base tube and a portion of the shapable element. The shapable element can be configured to deflect from an axis line causing the base tube and outer jacket to deflect along with the shapable element.

Abstract: A clot retrieval device for removing clot from a blood vessel including a plurality of ring elements comprising a plurality of struts forming one or more closed cells having one or more crown elements and attached together by connecting tethers at connection points, a plurality of openings through which clot may pass and enter the device, each opening being disposed between respective ring elements. Each ring element can be self-expandable from a collapsed configuration to an expanded configuration wherein a radial force biases the ring elements toward the expanded configuration. At least one of the crown element terminates in an apex away from a center axis of the device.

Abstract: A system for removing an occlusive clot from a blood vessel comprises a catheter and an apparatus for generating a pulsatile vacuum force to pulse the pressure gradient at a distal end of the catheter. The pulse generator may be integral with or separate from the vacuum pump. The pulse generator may be applied to a flexible tubing between the vacuum pump and the proximal end of the catheter.

Abstract: A clot capture device for restoring blood flow to a vessel occluded by a clot including a plurality of struts formed by interconnected fibers terminating in a distal end. An open proximal end includes a clot capture space larger than the distal end. The device includes an expanded deployed configuration and a retracted delivery configuration whereby the device is advanceable through a microcatheter across the clot, and the device is configured such that upon deployment the device is deployed distal to the clot and then withdrawn to remove the clot from the vessel.

Abstract: The designs herein can be for a clot retrieval catheter with a large bore lumen and a distal tip expandable to a diameter larger than that of the guide or sheath through which it is delivered. The designs can have a polymeric flared tip with atraumatic properties and the ability to flexibly expand when ingesting a clot. The tip can have a plurality of axial ribs giving stiffness to certain circumferential regions of the tip for facilitating repeatable collapse when retracted back into the guide or sheath. The tip can also have a metallic support frame within the flared tip for aiding in more gradual compression of clots during aspiration and retrieval with a stentriever. The catheter frame and tip can be sufficiently flexible to navigate highly tortuous areas of the anatomy and recover to maintain the inner diameter of the lumen when displaced in a vessel.

Abstract: A joint assembly for an endovascular device, comprising a shaft comprising a main body and an enlarged end, a proximal strut comprising a slot, wherein the slot engages the enlarged end of the shaft and a locking collar comprising a proximal face and a distal face, and at least partially covering the enlarged end of the shaft and the slot of the proximal strut, such that the locking collar constrains the proximal strut such that the proximal strut cannot disengage from the enlarged end of the shaft when the joint assembly and the clot retrieval device is under load.

Abstract: An expandable mechanical device for use during a thrombectomy medical procedure having enhanced visibility during imaging. Furthermore, the configuration of the eyelet and/or strut optimizes retention of the marker in the eyelet during the medical procedure without increasing overall profile of strut.

Abstract: A clot retrieval device comprising an elongate shaft having a proximal end and a distal end and a clot retrieval element at the distal end of the elongate shaft. A proximal end of the elongate shaft of the clot retrieval device is adapted for retraction of a first catheter over the clot retrieval device elongate shaft. A second catheter is advanced to or adjacent to the distal end of the clot retrieval device shaft to enable enhanced aspiration adjacent to the clot retrieval element.

Abstract: A system for removing occlusive clot from a blood vessel comprises a catheter and an apparatus for generating a pulsatile vacuum force to pulse the pressure gradient at a distal end of the catheter. The pulse generator may be integral with or separate from the vacuum pump. The pulse generator may be applied to a flexible tubing between the vacuum pump and the proximal end of the catheter.

Abstract: A system for assisting in the retrieval of a clot from a vessel. The system can include an outer catheter and an inner catheter disposed in a lumen of the outer catheter. The inner catheter can include a distal end, a proximal end, a distal segment, a proximal segment, and a lumen extending proximal of the distal end and terminating at a transfer port at the proximal end of the distal segment. A seal is located on the outer surface of the inner catheter distal of the transfer port, the seal capable of sealing against the lumen of the outer catheter so that aspiration applied through the outer catheter is configured to be transferred to the inner catheter.

Abstract: Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate.