Abstract: An aspiration clot retrieval catheter to have profiled guidewire for deliverability that transitions at a proximal joint to a distal tubular section with a lumen for directing aspiration and facilitating the smooth passage of other products in performing mechanical thrombectomy procedures. The joint can have a low-profile proximal strut formed integrally with the distal tubular section and configured to interlock with a distal portion of the guidewire so that there is a smooth transition of stiffness between the guidewire and the tubular portion of the catheter to improve trackability and decrease the likelihood of kinking. The distal tubular section of the proximal joint can also have features to tailor flexibility. The tubular section can be configured to push radially outward to form a seal with an outer catheter to optimize aspiration transmission to the distal mouth of the aspiration clot retrieval catheter.

Abstract: A system has an outer catheter and an inner aspirating clot retrieval catheter having an expansile distal tip for flow restriction, improved aspiration efficiency, and a large mouth into which a clot or other obstructions can be retrieved. The clot retrieval catheter can have a support tube proximal of the tip. The expansile tip can be a strut framework, and a flexible, low-modulus cover is disposed around at least a portion of the tip strut framework and the proximal support tube. The distal end of the tip can be encapsulated by a low-friction elastomeric lip for atraumatic contact with the walls of a blood vessel. The tip has a collapsed delivery configuration and expands radially into a deployed configuration. The tip strut framework, support tube, and cover can all have characteristics which enhance the deliverability of the clot retrieval catheter to the target.

Abstract: A clot retrieval device with an elongate shaft and an expandable section, the expandable section having a framework of interconnected strut elements distal of the elongate shaft, the strut elements forming an outer expandable body and an inner expandable body. At least a portion of the strut elements include a first coating of radiopaque material defining a plurality of micro-columns, wherein each micro-column includes a length extending between a first end coupled to one of the plurality of strut elements and a second free end opposite the first end, the length of each micro-column is longer than a width of each micro-column. The second free end is capable of moving further apart when a convex bend is applied to the respective strut element during use. Also including a second coating.

Abstract: A device for removing clot from a blood vessel includes a shaft. An expandable framework of struts is fixedly coupled to a distal region of the shaft. The struts can be radially expandable from a first to a second radially expanded state in a deployed configuration. An actuation cable can be connected to a plurality of connections of the engaging framework of struts to apply an expansion force, by the struts, as the struts are actuated by the actuation cable from the first radially expanded state to the second radially expanded state. In the first radially expanded state, a distal end of the struts is spaced a first axial distance away from the shaft, and wherein in the second radially expanded state, a distal end of the struts is spaced a second axial distance, different than the first axial distance, away from the shaft.

Abstract: A system for removing an obstruction from a blood vessel. The system can include a catheter with a proximal section with a proximal section lumen diameter, a distal section with a distal section lumen diameter less than the proximal section lumen diameter, an intermediate section extended between proximal and distal sections. The system can include a clot retrieval device with a clot engaging element. The system can include a shaft being advanceable through the lumen of the catheter the obstruction of the blood vessel, the shaft can include a shaft proximal section; a shaft distal section attached to the clot engaging element and configured to cross the obstruction, a diameter of the shaft proximal section being greater than a diameter of the shaft distal section thereby inhibiting the shaft proximal section from distally advancing through the catheter distal section.

Abstract: Shortly after completing a thrombectomy procedure, a temporary carotid filter can be deployed downstream of an occlusion not treated by the thrombectomy (e.g. a carotid lesion having plaque buildup), and the temporary carotid filter can remain in place during the patient's recovery period following the ischemic stroke until a procedure to treat the remaining occlusion is completed and antiplatelet therapy is administered. The temporary carotid filter can anchor in place while deployed with or without being tethered to a wire extending through the patient's Femoral Artery.

Abstract: An intravascular catheter including a distal porous cuff section having a plurality of unobstructed openings defined radially outward from an annular inflation chamber, wherein the distal porous cuff section is non-rotatable. The catheter also including a tubular body disposed proximally of the distal porous cuff section, the tubular body having a sidewall extending from a proximal end to the distal porous cuff section with an inner lumen defined axially therethrough. The sidewall of the tubular body having an inflation supply channel extending in a direction parallel to an axial direction of the intravascular catheter.

Abstract: A clot retrieval catheter can have an expansile distal tip for flow restriction/arrest and improved aspiration efficiency and a large, distal facing mouth into which clots or other obstructions can be retrieved. The tip can be formed from a distal ring of leaflets or hoops. One or more pull cables can be retracted to actuate and radially expand the expansile distal tip. The clot retrieval catheter can have a catheter shaft with flexibility-adding features proximal of the tip. The catheter shaft can be a multi-lumen configuration with a large catheter lumen for passing auxiliary devices and directing aspiration and one or more guide lumens which can route the pull cables to the leaflets or hoops of the expansile tip. A flexible, low-modulus membrane can be disposed around at least a portion of the expansile tip and catheter shaft.

Abstract: A device for retrieving an obstruction in a blood vessel can have an outer sheath with a distal end, a proximal end, a proximal luer encompassing the proximal end, and an internal lumen extending proximal of the distal end and terminating within the proximal luer; and an inner funnel catheter within the outer sheath comprising an expanding distal tip, a proximal end, a distal end located at the distal tip, a proximal luer encompassing the proximal end, and an internal lumen extending proximal of the distal end and terminating at the luer. The outer sheath and inner funnel catheter can be capable of moving telescopically with respect to each other. In some examples, a slider mechanism or rotating knob located on one of the proximal luers can be used to actuate the relative motion.

Abstract: A catheter including a distal tip section disposed on or adjacent the distal end of the catheter, the distal tip section being invertible about a transition between a catheter body and the distal tip section between a first configuration and a second configuration. Retracting the distal tip section causes the distal tip section to invert about the transition from the first to the second configuration, the second configuration comprising an expansile tip with an open funnel-like distal mouth comprising a larger diameter than a diameter of the transition.

Abstract: A device for removing a clot from a blood vessel. The device can have a collapsed delivery configuration and an expanded deployed configuration. The device can have a shaft. An outer expandable body can be included that is radially expandable from a first radially expanded state to a second radially expanded state in the deployed configuration. An inner body can be included, wherein the outer expandable body and the inner body are fixedly coupled to a distal region of the shaft, the outer expandable body radially surrounding at least a portion of the inner body in the second radially expanded state. A capture net can be coupled to a distal portion of the inner body and including a proximal mouth.

Abstract: An aspiration catheter including an elongate body and an expansile distal tip continuous with the elongate body. An expanding assembly is alignable internal to the expansile distal tip and connected proximally to a control wire. The expanding assembly includes a proximal position within the expansile distal tip proximal of a distal most end of the expansile distal tip. In a distal position where the expanding assembly is distally moved, by the control wire, until being aligned with and contacting the distal most end of the expansile distal tip causing the expansile distal tip to form a funnel mouth to receive clot.

Abstract: A thrombus retrieval device configured to restore blood flow in neurovasculature by removing thrombus in human patients experiencing ischemic stroke.

Abstract: A self-expanding intravascular medical device including a multi-component assembly with a self-expanding outer cage component comprising a plurality of struts; and a single cell wave-shape component disposed within the self-expanding outer cage component forming a channel therein. The proximal end of the single cell wave-shape component is connected to the self-expanding outer cage component at a proximal joint.

Abstract: A clot removal device for removing clot from a body vessel comprising an expandable structure and an elongate member. The elongate member can have a proximal end and a distal end, the elongate member being connected to the expandable structure at its distal end. The expandable structure can have a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure can be configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot pinching configuration.

Abstract: An expandable mechanical device for use during a thrombectomy medical procedure having enhanced visibility during imaging. Furthermore, the configuration of the eyelet and/or strut optimizes retention of the marker in the eyelet during the medical procedure without increasing overall profile of strut.

Abstract: Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel.

Abstract: A balloon guide catheter having a sleeved inflation lumen secured with a wire wrap for improved inflation lumen kink protection and a welded balloon construction provides a robust and flexible catheter with an exceptionally large inner lumen relative to its outer profile and enables rapid and reliable balloon inflation and deflation in a highly deliverable and kink resistant catheter. Balloon guide catheters having multiple sleeved inflation lumens and proximal luers for utilizing the multiple inflation lumens are also provided.

Abstract: An aspiration control device can have an aspiration control valve and a switch, button, slider, trigger, grip, lever, rotating wheel, rotating valve, handle or other interface for resizing the aspiration control valve. The aspiration control interface can be conveniently positioned and configured to be manipulated while simultaneously stabilizing a catheter and/or retracting an elongated member. The aspiration control device can be integrated with a hemostasis valve, integrated with a wire gripping device, and/or attached to an inlet, outlet, hose, pump, or syringe in series with an aspiration flow path.

Abstract: Shortly after completing a thrombectomy procedure, a temporary carotid filter can be deployed downstream of an occlusion not treated by the thrombectomy (e.g. a carotid lesion having plaque buildup), and the temporary carotid filter can remain in place during the patient's recovery period following the ischemic stroke until a procedure to treat the remaining occlusion is completed and antiplatelet therapy is administered. The temporary carotid filter can anchor in place while deployed with or without being tethered to a wire extending through the patient's Femoral Artery.