Abstract: The designs herein can be for a flexible and kink-resistant catheter with a support tube which can be radially expanded to enable it to be slid over an inner liner on a mandrel during assembly. The designs are flexible enough to allow the catheter to access remote vessel occlusions but also benefit from good compressive and tensile stiffness. The designs can have a laser cut frame with interlocking structure of circumferentially discontinuous rib struts. The discontinuities can be aligned to form at least one continuous axial seam which is separable to allow for the radial expansion during manufacturing. A series of polymeric outer jackets can coat or encapsulate the struts of the frame, giving variable stiffness and preventing disengagement of the interlocking structure while the catheter is pushed through tortuous anatomy.

Abstract: An expandable mechanical device for use during a thrombectomy medical procedure having enhanced visibility during imaging. Furthermore, the configuration of the eyelet and/or strut optimizes retention of the marker in the eyelet during the medical procedure without increasing overall profile of strut.

Abstract: A joint assembly for an endovascular device, comprising a shaft comprising a main body and an enlarged end, a proximal strut comprising a slot, wherein the slot engages the enlarged end of the shaft and a locking collar comprising a proximal face and a distal face, and at least partially covering the enlarged end of the shaft and the slot of the proximal strut, such that the locking collar constrains the proximal strut such that the proximal strut cannot disengage from the enlarged end of the shaft when the joint assembly and the clot retrieval device is under load.

Abstract: A clot capture catheter comprises an elongate tubular shaft having a proximal end, a distal end and an inflatable expansile member at the distal end. The expansile member is inflatable from a collapsed delivery configuration to an expanded configuration. In the expanded configuration, the expansile member extends to define a funnel shape having an enlarged distal clot entry mouth at the distal-most end of the catheter. In the expanded configuration, the expansile member may extend distally beyond the distalmost tip of the shaft. The expansile member may be integral with the distal tip of the catheter shaft.

Abstract: A device including a clot engaging device having a collapsed delivery configuration and an expanded deployment configuration. The device can include a plurality of struts defining a plurality of cells; a seam extending along at least a portion of a length of a distal end of the clot engaging device, wherein the seam comprises a pattern configured for gripping a clot and extends between cells of the plurality of cells; and a distal scaffolding region being distally tapered, wherein the distal scaffolding region comprises cells smaller than cells of a remainder of the clot engaging device.

Abstract: A self-expanding intravascular medical device including a multi-component assembly with a self-expanding outer cage component comprising a plurality of struts; and a single cell wave-shape component disposed within the self-expanding outer cage component forming a channel therein. The proximal end of the single cell wave-shape component is connected to the self-expanding outer cage component at a proximal joint.

Abstract: A clot removal device for removing clot from a body vessel comprising an expandable structure and an elongate member. The elongate member can have a proximal end and a distal end, the elongate member being connected to the expandable structure at its distal end. The expandable structure can have a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure can be configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot pinching configuration.

Abstract: A device for removing a clot from a vessel can have dual layers where an inner expandable body runs within an outer expandable body. The device can have a collapsed delivery configuration, an expanded deployed configuration, and a clot pinching configuration. The inner and outer bodies can be a plurality of cells formed by a network of struts. The openings of the cells align when the device is deployed within the clot, where the radial force from the expanding bodies urges portions of the clot through the openings. The inner and outer bodies can be configured to be selectively translatable relative to each other, so that the portions of the clot in the cell openings can be compressed and gripped when the translation transitions the device to the clot pinching configuration. The translation can be maintained to pinch the clot as it is retrieved from the patient.

Abstract: A clot retrieval device that includes a proximal scaffolding section with a closed proximal end and an open distal end; an inner elongate member; and a distal scaffolding section with a closed proximal end and an open distal end element.

Abstract: A method of removing clot from a vessel, including delivering a clot retrieval device across the clot, wherein the clot retrieval device includes an inner body having a collapsed delivery configuration and an expanded deployed configuration; and an outer body extending along a longitudinal axis and at least partially overlying the inner body. The outer body includes a first scaffolding section, a second scaffolding section hingedly connected distal of the first scaffolding section; the first and second scaffolding sections of the outer body being expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space between the inner and outer bodies. The method also includes expanding the clot retrieval device; and urging, by the expanding of the first and second scaffolding sections, at least a portion of the clot therebetween.

Abstract: A clot removal device for removing clot from a body vessel comprising an expandable structure and an elongate member. The elongate member can have a proximal end and a distal end, the elongate member being connected to the expandable structure at its distal end. The expandable structure can have a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure can be configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot pinching configuration.

Abstract: A device including a clot engaging device having a collapsed delivery configuration and an expanded deployment configuration. The device can include a plurality of struts defining a plurality of cells; a seam extending along at least a portion of a length of a distal end of the clot engaging device, wherein the seam comprises a pattern configured for gripping a clot and extends between cells of the plurality of cells; and a distal scaffolding region being distally tapered, wherein the distal scaffolding region comprises cells smaller than cells of a remainder of the clot engaging device.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: An expandable mouth for a catheter can be capable of local flow restriction and provide a large mouth opening providing sufficient radial force while having the flexibility to reach and retrieve an occlusive clot. The expandable mouth can have a framework with a collapsed state so the clot retrieval catheter can be compatible low-profile outer catheters and an expanded state for contacting the walls of a vessel and sealing off or restricting proximal flow. The framework can have one or more support arms and distal support hoops which can have narrowed segments, undulations, closed cells, and other flexibility enhancing features. Alternately, the framework can be a mesh having an array of closed cells. The expandable mouth can feature a membrane cover disposed around the supporting framework. These improvements can provide safe and rapid access to complex areas and more reliably remove occlusions while shortening procedure times.

Abstract: Manufacturing an expandable body of a clot retrieval device having a first coating of radiopaque material defining a plurality of micro-columns and a second coating, the method including applying the first coating to strut elements, removing at least a portion of the first coating from at least one area of the strut elements, and cutting away regions of both the first coating and the strut elements to form an interconnected pattern of coated and uncoated regions.

Abstract: A system for removing an obstruction from a blood vessel. The system can include a catheter with a proximal section with a proximal section lumen diameter and a distal section with a distal section lumen diameter less than the proximal section lumen diameter. The system can include a clot retrieval device with a clot engaging element. The system can include a shaft advanceable through the lumen of the catheter to the obstruction in the vessel. The shaft can include a shaft proximal section, a shaft distal section attached to the clot engaging element with a diameter less than that of the shaft proximal section and configured to cross the obstruction. The shaft proximal section diameter can be larger than the diameter of the distal section lumen diameter of the catheter, thereby inhibiting the shaft proximal section from distally advancing through the catheter distal section.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

Abstract: A clot retrieval catheter can have a tailored, highly flexible body section capable of navigating tortuous routes and an expandable tip for local flow restriction/arrest. The body can be a support tube of struts with a plurality of ribs and one or more axial spines. The support tube can also be a tubular section with a pattern of radial slots to increase flexibility while inhibiting kinking and binding. The ribs and spines can have strut widths which vary along the length of the support tube or can have curves with a non-planar cross section. The ribs can be formed such that they can move when subjected to the loads of a thrombectomy procedure. The structure of the support tube can also be a braided or woven pattern of strands. The support tube can also have a polymer jacket or membrane disposed around at least a portion of the structure.

Abstract: A system for treating tandem occlusions (e.g. a clot causing ischemic stroke downstream of a carotid lesion with plaque buildup) in the vasculature can have a carotid filter with a retrieval feature near the proximal end, a deployment system configured to engage the retrieval feature as the vascular filter is delivered intravascularly and disengage the retrieval feature when the filter is anchored in place, and an engagement system configured to engage the retrieval feature while the filter is anchored and retract the filter. The carotid filter can remain in place during the patient's recovery period following the ischemic stroke until a procedure to treat the remaining occlusion is completed.