Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.

Abstract: Disclosed herein are systems and methods for natural language processing for a call center. Audio data are received for at least a portion of a call between a call center representative and a call center user. An audio-to-text transcription of the call is generated upon processing the audio data. At least one generative model is applied to the transcription to obtain: a text summary of the call; answers to pre-defined questions relating to the customer and/or the call; and at least one assessment score of the call. In some cases, an electronic signal to trigger remedial action may be generated.

Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.

Abstract: A mold core for forming an injection molded article includes a first mold surface having a thread mold extending helically about a core axis for forming internal threading in a first portion of the molded article; and a second mold surface spaced radially apart from the first mold surface for forming a second portion spaced radially apart from the first portion and connected to the first portion by a connection portion. The second mold surface includes at least one rib mold feature for forming at least one ejection-assist rib of the second portion, the ejection-assist rib having a helical slide surface extending helically about the article axis. During an initial unscrewing rotation of the molded article relative to the mold core, the rib mold feature bears against the helical slide surface to urge the second portion axially away from the mold core during ejection of the molded article.

Abstract: An injection molded article includes: (a) an article first portion having internal threading extending helically about an article axis, the threading configured to be formed by a thread mold in a mold core; and (b) an article second portion spaced radially apart from the article first portion and connected to the article first portion by a connection portion. The article second portion has at least one ejection-assist rib configured to be formed by at least one rib mold feature in the mold core. The ejection-assist rib defines a helical slide surface extending helically about the article axis. During an initial unscrewing rotation of the molded article relative to the mold core, the rib mold feature of the mold core bears against the slide surface of the ejection-assist rib to urge the article second portion axially away from the mold core during ejection of the molded article from the mold core.

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.

Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.

Abstract: Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.

Abstract: A cap for a container includes an annular tamper evident band with a generally rigid cylindrical frame having an upper ring and a plurality of ribs extending axially from the ring and spaced circumferentially apart about the ring. A plurality of retainer elements are supported by the frame, each retainer element connected at circumferentially opposed ends by resiliently flexible webs to adjacent ones of the ribs. The retainer elements are biased to a radially contracted position, in which the retainer elements protrude inwardly to engage an underside surface of a neck flange of the container. The retainer elements are movable to a radially expanded position in which the retainer elements can be advanced axially past the neck flange when installing the cap onto the container for the first time.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.