Patents by Inventor David Yu

David Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12241912
    Abstract: An apparatus comprises a toggle member, a plurality of pogo pins, and a test board in operable communication with the toggle member. The pogo pins are coupled to the toggle member to move along a first axis when the toggle member moves along the first axis. Each pogo pin includes a plunger that moves within the pogo pin along the first axis. The pogo pins and respective plungers contact a top surface of the DUT when the DUT is coupled to the test board and positioned so that a conductor on its outer surface is aligns to and contacts a conductive region of the test board. Movement of the toggle member along the first axis translates to the plungers, applying a pressure sufficient to the top surface of the DUT to ensure flushmount electrical contact between the conductor of the DUT and the conductive region.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: March 4, 2025
    Assignee: RAYTHEON COMPANY
    Inventors: David Yu Shan Sun, Alfredo Rene Lara
  • Publication number: 20250034192
    Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.
    Type: Application
    Filed: September 30, 2024
    Publication date: January 30, 2025
    Inventors: Gaomai Yang, Jingshe Song, Shengdong Wang, Yun-Chiao Yao, Hongrong Yang, David Yu, Aldrich N.K. Lau
  • Publication number: 20250027091
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Application
    Filed: September 20, 2024
    Publication date: January 23, 2025
    Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Patent number: 12180140
    Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: December 31, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Gaomai Yang, Min Xie, Hongrong Yang, Shengdong Wang, Aldrich N. K. Lau, Ruiming Zou, David Yu
  • Patent number: 12134630
    Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.
    Type: Grant
    Filed: June 19, 2023
    Date of Patent: November 5, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Gaomai Yang, Jingshe Song, Shengdong Wang, Yun-Chiao Yao, Hongrong Yang, David Yu, Aldrich N.K. Lau
  • Patent number: 12116382
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: October 15, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Ruiming Zou, Aldrich N. K. Lau, David Yu, Guijun Yu, Zhixia Li
  • Patent number: 12098371
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Grant
    Filed: August 16, 2023
    Date of Patent: September 24, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Mufa Zou, David Yu, Aldrich N. K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Patent number: 12077811
    Abstract: Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: September 3, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: David Yu Zhang, Peng Yin
  • Publication number: 20240287120
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: April 25, 2024
    Publication date: August 29, 2024
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Aldrich N.K. Lau
  • Patent number: 12065516
    Abstract: Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.
    Type: Grant
    Filed: October 9, 2023
    Date of Patent: August 20, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Jingshe Song, John Michael Cue, Yun-Chiao Yao, David Yu, Aldrich N. K. Lau
  • Patent number: 12065460
    Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
    Type: Grant
    Filed: November 9, 2023
    Date of Patent: August 20, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Gaomai Yang, Yun-Chiao Yao, David Yu, Aldrich N. K. Lau
  • Patent number: 12054316
    Abstract: A cap for a container includes an annular tamper evident band with a generally rigid cylindrical frame having an upper ring and a plurality of ribs extending axially from the ring and spaced circumferentially apart about the ring. A plurality of retainer elements are supported by the frame, each retainer element connected at circumferentially opposed ends by resiliently flexible webs to adjacent ones of the ribs. The retainer elements are biased to a radially contracted position, in which the retainer elements protrude inwardly to engage an underside surface of a neck flange of the container. The retainer elements are movable to a radially expanded position in which the retainer elements can be advanced axially past the neck flange when installing the cap onto the container for the first time.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: August 6, 2024
    Assignee: CAP-THIN MOLDS INC.
    Inventor: David Yu
  • Publication number: 20240247023
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Application
    Filed: November 27, 2023
    Publication date: July 25, 2024
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Ruiming Zou, Aldrich N.K. Lau, David Yu, Guijun Yu, Zhixia Li
  • Publication number: 20240228433
    Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.
    Type: Application
    Filed: December 20, 2023
    Publication date: July 11, 2024
    Inventors: Gaomai YANG, Min XIE, Hongrong YANG, Shengdong WANG, Aldrich N.K. LAU, Ruiming ZOU, David YU
  • Patent number: 11993626
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: May 28, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Aldrich N. K. Lau
  • Publication number: 20240117362
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Application
    Filed: August 16, 2023
    Publication date: April 11, 2024
    Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Publication number: 20240092817
    Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.
    Type: Application
    Filed: November 9, 2023
    Publication date: March 21, 2024
    Inventors: Gaomai Yang, Yun-Chiao Yao, David Yu, Aldrich N.K. Lau
  • Publication number: 20240052071
    Abstract: Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 15, 2024
    Inventors: Jingshe Song, John Michael Cue, Yun-Chiao Yao, David Yu, Aldrich N.K. Lau
  • Patent number: 11897914
    Abstract: Embodiments of the present application relate to the preparation of 2?-O-protected nucleoside phosphoramidites and conjugation of the 2?-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2? position that reduces migration to the 3? position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: February 13, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Ruiming Zou, Aldrich N. K. Lau, David Yu, Gengyu Du, Yun-Chiao Yao, Gang Zhao
  • Patent number: 11884691
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: May 18, 2023
    Date of Patent: January 30, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Mufa Zou, Xiaoyang Guan, Xiaoling Zheng, David Yu, Ruiming Zou, Aldrich N. K. Lau