Abstract: A modular plunger packing gland assembly for a plunger of a hydraulic frac pump is disclosed. The modular plunger packing gland assembly includes an annular packing nut configured to be disposed circumferentially about the plunger and proximate a plurality of annular seals disposed about the plunger, and an annular packing gland having an inner circumferential threaded interface configured to engage an external circumferential thread defined on the packing nut. The annular packing gland further defines a plurality of threaded openings configured to receive a plurality of threaded bolts configured to securely fasten the annular packing gland and the packing nut to the pump.

Abstract: Some aspects of this disclosure provide a fusion protein comprising a guide nucleotide sequence-programmable DNA binding protein domain (e.g., a nuclease-inactive variant of Cas9 such as dCas9), an optional linker, and a recombinase catalytic domain (e.g., a tyrosine recombinase catalytic domain or a serine recombinase catalytic domain such as a Gin recombinase catalytic domain). This fusion protein can recombine DNA sites containing a minimal recombinase core site flanked by guide RNA-specified sequences. The instant disclosure represents a step toward programmable, scarless genome editing in unmodified cells that is independent of endogenous cellular machinery or cell state.

Abstract: A device, such as Network Microphone Device or a playback device, receives an indication of a track change associated with a playback queue output by a media playback system. In response, an input detection window is opened for a given time period. During the given time period the device is arranged to receive an input sound data stream representing sound detected by a microphone. The input sound data stream is analyzed for a plurality of command keywords and/or a wake-word for a Voice Assistant Service (VAS) and, based on the analysis, it is determined that the input sound data stream includes voice input data comprising a command keyword or a wake-word for a VAS. In response, the device takes appropriate action such as causing the media playback system to perform a command corresponding to the command keyword or sending at least part of the input sound data stream to the VAS.

Abstract: Embodiments of golf club heads having adjustable weighting systems with a plurality of discrete attachment locations capable of receiving one or more weights are described herein. The golf club heads described herein provide user adjustability of club head center of gravity to adjust ball flight while maintaining a high moment of inertia and low and back center of gravity position.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating an output sequence from an input sequence. One of the methods includes, at each of a plurality of generation time steps: generating a combined sequence for the generation time step that includes the input sequence followed by the output tokens that have already been generated as of the generation time step; processing the combined sequence using a self-attention decoder neural network to generate a time step output that defines a score distribution over a set of possible output tokens; and selecting, using the time step output, an output token from the set of possible output tokens as the next output token in the output sequence.

Abstract: An optical system includes an optical film curved about a first axis and a light control film curved about the first axis and substantially coextensive with the optical film. The optical film includes a first layer including a microstructured first major surface where the microstructured first major surface defines a linear Fresnel lens including a plurality of Fresnel elements extending along the first axis. The first major surface of the optical film faces the light control film. The light control film includes a plurality of spaced apart optically absorptive regions extending along the first axis and along a direction substantially normal to a major surface of the light control film. At least one of the optical film or at least one layer disposed between the optical film and the light control film includes at least one reflection mitigation element.

Abstract: Embodiments described herein can enable minimum processing performed at a signal device level, such that the majority of the non-domain-specific processing can be offloaded to a processing device. For example, the processing device can receive signal data from a signal device, preprocess the signal data to obtain preprocessed signal data having a data format for domain-specific processing by software executed by at least one processing unit of a processing platform, and provide the preprocessed signal data for domain-specific processing by the software executed by the at least one processing unit.

Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.

Abstract: A system, method, and apparatus for autonomous body interaction system is provided. A system and method for a robot interacting with a human or other soft or deformable body is provided for the purpose of active application of pressure to specific points or regions of the body. The system and method conducts at least one of: localizing the position of the body, detecting the configuration of the body, identifying the surface region(s) of the body, predicting the underlying anatomy of the body, assessing the state of the body, preparing a plan for manipulation of the body, and executing a predetermined and/or dynamically updated plan on the body.

Abstract: Methods, systems, and apparatuses are described herein for improving computer authentication processes using vocal confidence processing. A request for access to an account may be received. An authentication question may be provided to a user. Voice data indicating one or more vocal utterances by the user in response to the authentication question may be received. The voice data may be processed, and a first confidence score that indicates a degree of confidence of the user when answering the authentication question may be determined. An overall confidence score may be modified based on the first confidence score. Based on determining that the overall confidence score satisfies a threshold, data preventing the authentication question from being used in future authentication processes may be stored. The data may be removed when a time period expires.

Abstract: The invention provides non-opioid pain therapeutic compositions that include an antisense oligonucleotide (ASO) complementary to an identified target on a NaV channel mRNA. The ASO hybridizes to its target RNA and forms a duplex that recruits RNase H to degrade the RNA, thereby downregulating NaV channel synthesis, which inhibits the neuron's ability to contribute to the perception of pain. The ASO targets one of the specific identified targets, and may be provided as a gapmer that includes a central DNA segment flanked by modified RNA wings. When the composition is delivered to dorsal root ganglion (DRG) neurons in vitro the DRG neurons exhibit a dose-dependent knockdown of NaV 1.7 NaV 1.8 or NaV 1.9.

Abstract: Aspects of the present disclosure involve systems, methods, computer program products, and the like, for utilizing a CIC value field in signaling information of a communication to provide an identification of the ingress network to an egress or receiving network of a long distance telecommunications network. The system and method provides for the provisioning of a signaling CIC for an ingress trunkgroup or network to a telecommunications network for downstream signaling purposes by overriding a received CIC value with a provisioned CIC value specific to the ingress network. This provisioned CIC value identifies the ingress network to the long distance network to the egress network for use by the egress network.

Abstract: A system and method for dynamically adjusting channel orientation as a function of a listener's orientation. The invention employs a spatial mapping of the plurality of audio transducers within a given listening space and routes the audio output intended for each of the transducers based upon the orientation of a listener within the space. Ideally, the listener's orientation is determined via a sensor worn, held or otherwise affixed to the listener.

Abstract: Herein is reported a class of chiral compounds with paradoxical effects on the androgen receptor (AR). The (R)-enantiomers behave like classical anti-androgens while the (S)-enantiomers activate AR signaling. In castration-resistant prostate cancer, the change during the course of therapy to growth in the presence of AR targeted therapeutics, a harbinger of progression to lethal disease, is commonly attributed to acquired mutations of the AR-ligand binding domain. This is the first report of an antagonist -agonist duality solely due to structural enantiomerism, without any modification to the AR binding site.

Abstract: A tool for forming a composite structure may include two or more segments formed from a polymer material. The tool may further include a crush insert disposed between the two or more segments. The tool may also include a support shaft coupled between the two or more segments. A method of forming a mandrel may include forming segments of the mandrel through an additive manufacturing process. The method may further include assembling the segments relative to one another. The method may also include positioning a crush insert between each of the segments. A method of fabricating a composite structure is also disclosed.

Abstract: In some embodiments, apparatuses and methods are provided herein useful for identifying an object using radiopaque ink. In some embodiments, a system for identifying an object comprises an object having an identifying marking formed of a radiopaque ink comprising a polymer matrix having an average molecular weight of about 1,000 g/mol to about 50,000 g/mol, and a radiopaque compound comprising one or more elements having an atomic number of 53 or greater dispersed within the polymer matrix. A control circuit causes a radiographic imaging device to irradiate the object, receives from the radiographic imaging device image data associated with the object, processes the image data to generate an x-ray image showing the identifying marking of the object, causes a display device to display the x-ray image showing the identifying marking of the object, and identifies the object based on the identifying marking of the object shown in the x-ray image.

Abstract: A method for manufacturing a prosthetic component include injection molding a prosthetic component with a polymeric material. The prosthetic component includes a final surface positioned on one side and multiple coring features positioned on an opposite side. The coring features may include multiple ribs and slots. The method further includes machining the prosthetic component to remove the coring features and form a final surface on the opposite side. The prosthetic component may be a femoral component for a prosthetic knee joint.

Abstract: An exercise device consisting of two or more flexible elements originating from different locations and connected to a common handle capable of being moved in a variety of directions. Each element also connected to a resistance mechanism and a force measuring device whereby a user interface and microcomputer determine force and direction and enable creation of customized workouts.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for providing voice control using multiple digital assistants. In some embodiments, a voice platform operates to receive a voice input from a user. The voice platform selects a digital assistant from a plurality of digital assistants based on a trigger word. The voice platform then generates an intent from the voice input using the selected digital assistant. The voice platform then transmits the intent to a media device for processing.

Abstract: A housing may, for example, include a housing part which may include a receiving part. The receiving part may, for example, include a first wall structure and a second wall structure. The second wall structure may be opposing the first wall structure. Moreover, the first wall structure may be shorter as compared to the second wall structure. The housing may further include a housing portion which may be coupled to the housing part. The housing part and the housing portion, when coupled, may form an enclosure which may be associated with an enclosed area within which one or more components may be carried. The component(s) may, for example, be carried in a manner such that Ingress Protection (e.g., water Ingress Protection) may be facilitated.