Patents by Inventor Di Chen

Di Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230101807
    Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. In certain examples, the present disclosure provides a method of increasing expression of a Klotho gene in a cell the method comprising administering to the cell a binding molecule that binds to an RNA transcript transcribed from a chromosomal region within or near the Klotho gene, wherein the RNA transcript does not encode a Klotho protein.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 30, 2023
    Inventors: Ci-Di Chen, Ella Zeldich, Carmela Abraham
  • Patent number: 11586919
    Abstract: A task-based learning using task-directed prediction network can be provided. Training data can be received. Contextual information associated with a task-based criterion can be received. A machine learning model can be trained using the training data. A loss function computed during training of the machine learning model integrates the task-based criterion, and minimizing the loss function during training iterations includes minimizing the task-based criterion.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: February 21, 2023
    Assignee: International Business Machines Corporation
    Inventors: Yada Zhu, Di Chen, Xiaodong Cui, Upendra Chitnis, Kumar Bhaskaran, Wei Zhang
  • Publication number: 20230018134
    Abstract: This application provides a live streaming processing method performed by an electronic device. The method includes: displaying a live streaming room, the live stream room having a host account, a host sub-account and multiple viewer accounts, the host sub-account being used for assisting the host account of the live streaming room in operation; receiving real-time live streaming data of the live streaming room, and displaying a live streaming content on a live streaming room page according to the real-time live streaming data, the real-time live streaming data collected from the host account and the viewer accounts; and displaying, in response to a live streaming room operation of the host sub-account, an operation result of the live streaming room operation of the host sub-account in the live streaming room, wherein the operation result of the live streaming room operation updates the live streaming content on the live streaming room page.
    Type: Application
    Filed: September 19, 2022
    Publication date: January 19, 2023
    Inventors: Longqi DING, Di CHEN, Shuyou LI, Hengkai WAN, Junqiu LU, Yan LONG, Fenglian WEI, Ting HUANG
  • Publication number: 20220391082
    Abstract: A special effect processing method, an apparatus, an electronic device and a computer readable storage medium. Where the method includes: displaying (S11) a special effect behavior window in response to a special effect adding operation of a special effect configuration window, where the special effect behavior window includes a special effect adding button and a trigger adding button; adding (S12) at least one special effect object in the special effect behavior window in response to the special effect adding operation of the special effect adding button; setting (S13) at least one triggering operation for a special effect behavior corresponding to the special effect behavior window in response to a trigger adding operation of the trigger adding button, where the at least one triggering operation is used to trigger the special effect behavior to be displayed; and generating (S14) a special effect event according to the special effect behavior.
    Type: Application
    Filed: August 11, 2022
    Publication date: December 8, 2022
    Inventors: Ruifeng MA, Le GAO, Yantong WEI, Haozhe LI, Di CHEN
  • Publication number: 20220348911
    Abstract: The present disclosure relates to a method for constructing a whole genome high-throughput sequencing library comprising the following steps: (1) extracting a sample gDNA; (2) fragmenting said sample gDNA by enzyme cleavage, filling ends of the gDNA and adding A base to the gDNA fragments to obtain an A-added gDNA; (3) connecting the A-added gDNA with a linker combination to obtain a connected produce, said linker combination comprises two parts: a Y-shaped reverse linker and a high GC clamp linker; (4) purifying said connected product to obtain a purified product; and (5) screening the fragment of said purified product to obtain a sequencing library. The present disclosure also relates to a kit for constructing a whole genome high-throughput sequencing library.
    Type: Application
    Filed: February 17, 2022
    Publication date: November 3, 2022
    Inventors: Jianguang Zhang, Di Chen, Ling Shang
  • Publication number: 20220251549
    Abstract: The present invention provides a method for constructing a capture library, comprising the steps of: (1) obtaining fragmented DNAs; (2) connecting the fragmented DNAs with a Y-shaped linker to obtain a pre-library; (3) hybridizing the pre-library and a hybridization probe in the absence of a blocking sequence to obtain hybridization products; and (4) performing a PCR amplification on the hybridization products to obtain the capture library. The present invention also provides to a kit for carrying out the method.
    Type: Application
    Filed: July 24, 2020
    Publication date: August 11, 2022
    Inventors: Dan Gui, Di Chen, Guangyuan Wang, Jianguang Zhang
  • Publication number: 20220218896
    Abstract: An apparatus for drug delivery is presented in accordance with aspects of the present disclosure. The apparatus includes a laser-driven photoacoustic microfluid pump (LDMP), an open tube capillary including a first end and a second end; the first end disposed on the LDMP, the open tube capillary configured to store a drug. The LDMP is configured to generate a fluidic jet from the drug and deliver the drug.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 14, 2022
    Inventors: Jiming Bao, Wei-Kan Chu, Feng Lin, Shuai Yue, Di Chen, Dennis McWilliams
  • Publication number: 20220126397
    Abstract: A laser beam shaping device includes a multi-zone structure lens and a focusing lens. The multi-zone structure lens includes a lens body and a refractive structure. The lens body has an incident plane and an emission plane, and one of the incident plane and the emission plane is furnished with the refractive structure. The light source passing through the refractive structure deviates and leaves the lens body via the emission plane. The light source passing through the lens body is divided into N sets of light beams. After the N sets of light beams penetrate through the focusing lens, N set of incident beams are formed to project the interface of the first material and the second material in an oblique inward manner with respect to the optical axis of the focusing lens. In additional, a laser processing system and a laser interlocking welding structure respectively are also provided.
    Type: Application
    Filed: November 28, 2020
    Publication date: April 28, 2022
    Inventors: YUAN-DI CHEN, WU-JUNG TSAI, CHIA-YU HU
  • Publication number: 20220076068
    Abstract: A method for constructing a convolutional neural network model based on farmland images is applied in an electronic device. The method includes following steps: obtaining a number of farmland images of at least one farmland; obtaining a plurality of standard segmentation farmland images corresponding to each of the farmland images; dividing the farmland images and the standard segmentation farmland images into a training image set and a test image set; taking the farmland images and the standard segmentation farmland images in the training image set as input of a convolutional neural network, and constructing a convolutional neural network model based on the farmland images; and verifying the convolutional neural network model by using the farmland images in the test image set and the standard segmentation farmland images, and optimizing a plurality of parameters of the convolutional neural network model based on the farmland images.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 10, 2022
    Inventors: Di Wu, ZHAO-DI CHEN, MIN-XIN CHEN, CHEN-JIAN WU, HONG CHEN
  • Patent number: 11254302
    Abstract: A vehicle control method in a hybrid electric vehicle including an internal combustion engine, a battery, an electric motor, and a control unit. The method includes estimating an estimated vehicle velocity trajectory, estimating an initial engine power trajectory, simulating state of charge of the battery with the vehicle velocity trajectory and the initial engine power trajectory, estimating an initial terminal co-state value, simulating backward co-state dynamics using the state of charge and vehicle velocity trajectory, to obtain a resulting co-state trajectory. The co-state trajectory is used to solve a minimization control and propagate state of charge dynamics forward in time. The method includes updating control and the co-state trajectory, adjusting the terminal co-state value, and controlling a usage of the battery and the internal combustion engine. The method can be performed to optimize the engine power trajectory to minimize fuel consumption in real time.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: February 22, 2022
    Assignees: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mike X. Huang, Di Chen
  • Patent number: 11226198
    Abstract: A three-dimensional scanning system includes a projection light source, an image capturing apparatus, and a signal processing apparatus. The projection light source is configured to project a two-dimensional light to a target, where the two-dimensional light has a spatial frequency. The image capturing apparatus captures an image of the target illuminated with the two-dimensional light. The signal processing apparatus is coupled to the projection light source and the image capturing apparatus, to analyze a definition of the image of the two-dimensional light, where if the definition of the image of the two-dimensional light is lower than a requirement standard, the spatial frequency of the two-dimensional light is reduced.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: January 18, 2022
    Assignee: BENANO INC.
    Inventors: Liang-Pin Yu, Yeong-Feng Wang, Chun-Di Chen, Yun-Ping Kuan
  • Publication number: 20220008518
    Abstract: Disclosed are compositions containing a therapeutically effective amount of free recombinant or synthetic lubricin, a lubricin-supplemented preserved AM, or a lubricin-supplemented non-AM substrate for promoting tissue reconstruction and wound healing in a subject and the methods of using thereof. Lubricin-supplemented preserved amniotic membranes and lubricin-supplemented non-AM substrates, and methods of preparing thereof are also described.
    Type: Application
    Filed: November 7, 2019
    Publication date: January 13, 2022
    Inventors: Yang Liu, Di Chen, David A. Sullivan
  • Patent number: 11208186
    Abstract: A water-air amphibious cross-medium bio-robotic flying fish includes a body, pitching pectoral fins, variable-structure pectoral fins, a caudal propulsion module, a sensor module and a controller. The caudal propulsion module is controlled to achieve underwater fish-like body-caudal fin (BCF) propulsion, and the variable-structure pectoral fins is adjusted to achieve air gliding and fast splash-down diving motions of the bio-robotic flying fish. The coordination between the caudal propulsion module and the pitching pectoral fins is controlled to achieve the motion of leaping out of water during water-air cross-medium transition. The ambient environment is detected by the sensor module, and the motion mode of the bio-robotic flying fish is controlled by the controller.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: December 28, 2021
    Assignee: INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES
    Inventors: Junzhi Yu, Zhengxing Wu, Di Chen, Min Tan
  • Publication number: 20210397941
    Abstract: A task-based learning using task-directed prediction network can be provided. Training data can be received. Contextual information associated with a task-based criterion can be received. A machine learning model can be trained using the training data. A loss function computed during training of the machine learning model integrates the task-based criterion, and minimizing the loss function during training iterations includes minimizing the task-based criterion.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 23, 2021
    Inventors: Yada Zhu, Di Chen, Xiaodong Cui, Upendra Chitnis, Kumar Bhaskaran, Wei Zhang
  • Publication number: 20210398875
    Abstract: Low inductance power modules for ultra-fast wide-bandgap semiconductor power switching devices are disclosed. Conductive tracks define power buses for a switching topology, e.g. comprising GaN E-HEMTs, with power terminals extending from the power buses through the housing to provide a heatsink-to-busbar distance which meets creepage and clearance requirements. Low-profile, low-inductance terminals for gate and source-sense connections extend from contact areas located adjacent each power switching device to provide for a low inductance gate drive loop, for high di/dt switching. The gate driver board is mounted on the low-profile terminals, inside or outside of the housing, with decoupling capacitors provided on the driver board. For paralleled switches, additional terminals, which are referred to as dynamic performance pins, are provided to the power buses.
    Type: Application
    Filed: September 2, 2021
    Publication date: December 23, 2021
    Inventors: Juncheng LU, Di CHEN, Larry SPAZIANI, Peter Anthony DI MASO
  • Patent number: 11199394
    Abstract: An apparatus for three-dimensional shape measurement is provided, including a projection device, an image capture device, and an image processing device. The projection device sequentially projects a plurality of structured light beams on a scene during a first projection period and a second projection period. The mean level of the structured light beams during the first projection period is the same as the mean level of the structured light beams during the second projection period, and the frequency of the structured light beams during the first projection period is different from the frequency of the structured light beams during the second projection period. The image capture device captures an image of the scene within the projection time of each of the structured light beams. The image processing device obtains a three-dimensional shape of a to-be-measured object in the scene according to the images.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: December 14, 2021
    Assignee: BENANO INC.
    Inventors: Liang-Pin Yu, Yeong-Feng Wang, Chun-Di Chen
  • Publication number: 20210380648
    Abstract: The present disclosure relates to compositions and methods for modulating gene expression and in particular to DNA binding proteins and their use for increasing expression of Klotho. In some examples, the present disclosure provides an isolated or recombinant DNA binding protein comprising or attached to a transcriptional activation domain wherein the DNA binding protein binds to a target sequence within or near a Klotho gene.
    Type: Application
    Filed: December 16, 2019
    Publication date: December 9, 2021
    Inventor: Ci-Di Chen
  • Publication number: 20210370907
    Abstract: A vehicle control method in a hybrid electric vehicle including an internal combustion engine, a battery, an electric motor, and a control unit. The method includes estimating an estimated vehicle velocity trajectory, estimating an initial engine power trajectory, simulating state of charge of the battery with the vehicle velocity trajectory and the initial engine power trajectory, estimating an initial terminal co-state value, simulating backward co-state dynamics using the state of charge and vehicle velocity trajectory, to obtain a resulting co-state trajectory. The co-state trajectory is used to solve a minimization control and propagate state of charge dynamics forward in time. The method includes updating control and the co-state trajectory, adjusting the terminal co-state value, and controlling a usage of the battery and the internal combustion engine. The method can be performed to optimize the engine power trajectory to minimize fuel consumption in real time.
    Type: Application
    Filed: May 26, 2020
    Publication date: December 2, 2021
    Applicants: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mike X. HUANG, Di Chen
  • Patent number: 11183440
    Abstract: Low inductance power modules for ultra-fast wide-bandgap semiconductor power switching devices are disclosed. Conductive tracks define power buses for a switching topology, e.g. comprising GaN E-HEMTs, with power terminals extending from the power buses through the housing to provide a heatsink-to-busbar distance which meets creepage and clearance requirements. Low-profile, low-inductance terminals for gate and source-sense connections extend from contact areas located adjacent each power switching device to provide for a low inductance gate drive loop, for high di/dt switching. The gate driver board is mounted on the low-profile terminals, inside or outside of the housing, with decoupling capacitors provided on the driver board. For paralleled switches, additional terminals, which are referred to as dynamic performance pins, are provided to the power buses.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 23, 2021
    Assignee: GaN Systems Inc.
    Inventors: Juncheng Lu, Di Chen, Larry Spaziani, Peter Anthony Di Maso
  • Publication number: 20210354800
    Abstract: A water-air amphibious cross-medium bio-robotic flying fish includes a body, pitching pectoral fins, variable-structure pectoral fins, a caudal propulsion module, a sensor module and a controller. The caudal propulsion module is controlled to achieve underwater fish-like body-caudal fin (BCF) propulsion, and the variable-structure pectoral fins is adjusted to achieve air gliding and fast splash-down diving motions of the bio-robotic flying fish. The coordination between the caudal propulsion module and the pitching pectoral fins is controlled to achieve the motion of leaping out of water during water-air cross-medium transition. The ambient environment is detected by the sensor module, and the motion mode of the bio-robotic flying fish is controlled by the controller.
    Type: Application
    Filed: April 16, 2020
    Publication date: November 18, 2021
    Applicant: INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES
    Inventors: Junzhi YU, Zhengxing WU, Di CHEN, Min TAN