Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A key entry device including a housing, a keypad array disposed within the housing and including a plurality of keys, a key contact array disposed within the housing below the keypad array and including a plurality of contact pairs, a dome array underlying the keypad array and the key contact array and including a plurality of domes, and a protrusion array underlying the dome array and including a plurality of protrusions, whereby depression of one of the plurality of keys of the keypad array causes a corresponding one of the domes of the dome array to be displaced downwardly and to be deformed by pushing engagement with a corresponding one of the protrusions of the protrusion array into contact with at least one of the contact pairs of the key contact array.

Abstract: A Control Neutron Absorber (CNA) assembly for a microreactor that produces nuclear energy is disclosed. The CNA assembly includes a housing, a CNA rod, and a burnable absorber. The housing includes an inner housing and an outer housing. The inner housing is configured to receive a CNA rod. The outer housing extends coaxially with the inner housing and is positioned radially outward and offset from the inner housing defining a cavity therebetween. The CNA rod includes a neutron absorbing rod including a first neutron absorbing material. The neutron absorbing rod is positioned within the inner housing and is configured to move axially relative to the inner housing. The burnable absorber includes a second neutron absorbing material, exhibits a neutron absorbing strength that is less than that of the neutron absorbing rod, is positioned within the inner housing, and is configured to receive the neutron absorbing rod therein.

Abstract: A medical device according to certain embodiments generally includes a first wall, a second wall, and a first deformable reinforcing member. The first wall and the second wall are joined to one another such that a cavity is formed between the first wall and the second wall. The cavity has an outlet opening formed at a proximal end of the medical device. The first deformable reinforcing member is attached to the first wall, and is deformable by manual application of pressure to lateral edges of the first deformable reinforcing member so as to radially distend the outlet opening. The first deformable reinforcing member includes at least one first notch formed in at least one lateral edge thereof. Each notch is configured to receive a portion of a user's digit to facilitate manual application of pressure to said lateral edges.

Abstract: A method including displaying, in a graphical user interface (GUI) of a computer, a map of a plurality of airport taxiways. The method also includes receiving a start point on the map. The method also includes receiving an endpoint on the map. The method also includes generating, automatically, a path for an aircraft to take to navigate the plurality of taxiways from the start point to the endpoint. The method also includes superimposing the path on the map in the GUI.

Abstract: A light detection and measurement device comprises a silicon photomultiplier, at least one thermoelectric cooler thermally coupled to the silicon photomultiplier, a sealed enclosure surrounding the silicon photomultiplier and the at least one thermoelectric cooler, the enclosure including a substantially transparent window thermally coupled to the silicon photomultiplier, and a heat sinking device thermally coupled to the enclosure configured to remove waste heat. A method of cooling a silicon photomultiplier is also described.

Abstract: A medical device according to certain embodiments generally includes a first wall, a second wall, and a first deformable reinforcing member. The first wall and the second wall are joined to one another such that a cavity is formed between the first wall and the second wall. The cavity has an outlet opening formed at a proximal end of the medical device. The first deformable reinforcing member is attached to the first wall, and is deformable by manual application of pressure to lateral edges of the first deformable reinforcing member so as to radially distend the outlet opening. The first deformable reinforcing member includes at least one first notch formed in at least one lateral edge thereof. Each notch is configured to receive a portion of a user's digit to facilitate manual application of pressure to said lateral edges.

Abstract: An automatic transferring washer and dryer combination appliance includes a washing unit and drying unit that are coupled to a housing and are positioned in an upper portion and a lower portion of the housing, respectively. A chute extends between the washing unit and the drying unit. A first orifice and a second orifice are positioned in a tub of the washing unit and a drum of the drying unit, respectively. A plurality of first doors and a plurality of second doors, which are coupled to the tub and to the drum, respectively, are positioned to selectively close the first orifice the second orifice, respectively. The first doors and the second doors are positioned to be selectively opened so that the first orifice and the second orifice align with the chute so that the chute is configured for gravitational transfer of washed articles from the tub to the drum.

Abstract: An automatic transferring washer and dryer combination appliance includes a washing unit and drying unit that are coupled to a housing and are positioned in an upper portion and a lower portion of the housing, respectively. A chute extends between the washing unit and the drying unit. A first orifice and a second orifice are positioned in a tub of the washing unit and a drum of the drying unit, respectively. A plurality of first doors and a plurality of second doors, which are coupled to the tub and to the drum, respectively, are positioned to selectively close the first orifice the second orifice, respectively. The first doors and the second doors are positioned to be selectively opened so that the first orifice and the second orifice align with the chute so that the chute is configured for gravitational transfer of washed articles from the tub to the drum.

Abstract: Described herein is a medical device with an opening system. The medical device is foldable from an open to a closed condition. It is secured in its closed condition. In certain embodiments, the medical device is an ostomy pouch.

Abstract: Methods and devices are disclosed for managing a resource of a communication device configured to process and communicate medical data in addition to other data. The systems and devices may implement the method, including determining whether to switch to a medical mode based on at least one signal. In response to determining to switch to the medical mode, the communication device may be switched to the medical mode. A resource status associated with a plurality of resources used by the communication device may be weighed against a medical data criticality associated with the medical data managed by the communication device. The method may include allocating a resource of the plurality of resources on a sliding priority scale. The allocating may include allocating a resource of the plurality of resources preferentially to the medical data over the other data.

Abstract: Certain aspects of the present disclosure provide a cloud-based platform for monitoring patient adherence to a medication regimen. A cloud-based platform to monitor and promote patient adherence, as described herein, may help enable various useful applications.

Abstract: Certain aspects of the present disclosure provide a platform for monitoring patient adherence to a medication regimen. Certain aspects of the present disclosure also proved various components that may help enable such a platform, such as a smart collar capable of detecting removal and/or insertion of objects from a container (such as a pill container).

Abstract: Certain aspects of the present disclosure provide a platform for monitoring patient adherence to a medication regimen. Certain aspects of the present disclosure also proved various components that may help enable such a platform, such as a smart collar capable of detecting removal and/or insertion of objects from a container (such as a pill container). Aspects of the present disclosure also provide for tailored communications with a patient. For example, a mode of communicating with the patient to encourage adherence with a medication regimen may be adjusted based on feedback regarding why the patient is not adhering to the regimen.

Abstract: Certain aspects of the present disclosure provide a platform for monitoring patient adherence to a medical regimen. Certain aspects of the present disclosure also proved various components that may help enable such a platform, such as a smart collar capable of detecting removal and/or insertion of objects from a container (such as a pill container). In some cases, a smart collar may include a first portion having sides adapted to guide objects toward an opening in the first portion sized to allow the objects to pass, at least one detector proximate the opening and responsive to removal of objects from the container as they pass through the opening in the first portion, and a processor configured to process a first signal generated by the detector to update a monitored count of objects in the container.

Abstract: The present invention relates to pyrimidine derivatives capable of inhibiting one or more protein kinases. Further aspects relate to pharmaceutical compositions comprising the pyrimidine derivatives and the use thereof in the treatment of proliferative disorders.

Abstract: Embodiments of the present disclosure are directed towards a venting hatch having a base configured to couple to a storage container, wherein the base comprises a central opening configured to be exposed to an opening of the storage container, a cap coupled to the base, a seal disposed between the base and the cap, and an actuating mechanism configured to exert a biasing force on the seal to bias the seal against an annular lip of the base, wherein the actuating mechanism is disposed on an exterior surface of the cap.

Abstract: The present invention relates to pyrimidine derivatives capable of inhibiting one or more protein kinases. Further aspects relate to pharmaceutical compositions comprising the pyrimidine derivatives and the use thereof in the treatment of proliferative disorders.

Abstract: The present invention relates to a compound of formula (VII)I, or pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N—(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4? are each independently H or alkyl; or R4 and R4? together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.