Abstract: Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Abstract: A self-expanding aneurysm cover device which takes the form of an outwardly biased cylindrical skeletal frame in which the proximal end of the cylindrical skeletal frame forms a loop which extends at an oblique angle to the axis of the cylindrical skeletal frame. A positioning tab extends from the proximal end of the skeletal frame which when pulled causes the cylindrical skeletal frame to collapse to a reduced diameter for removal of the device from a vessel.

Abstract: Thin film metallic devices implantable within a human subject for occlusion of an aneurysm or blood vessel are provided. The devices include an embolization element that is moveable between a collapsed configuration for delivery to a deployed configuration within the body. The embolization device plugs the aneurysm or blood vessel preventing blood from flowing into or out of the aneurysm or other defective or diseased location of the blood vessel. The embolization element may be either self-supporting or supported by a strut structure. The occlusion device also includes an anchor element for anchoring the occlusion device and aiding in maintaining the embolization element in place. The anchor element is connected to the embolization device via a connector element.

Abstract: Compounds of formula (I) in which R1, R2, R3 and R4, have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.

Abstract: A vascular occlusive device which includes a vascular occlusive embolic coil, a bioactive coating disposed onto the embolic coil, and an outer barrier coating which serves to prevent a reaction between the bioactive agent in the bioactive coating and bodily fluids, until the outer barrier is activated by applying an external agent to the outer barrier.

Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device. The expandable reaction chamber, prior to deployment, has multiple chambers separated by a heat-dissolvable membrane. When the membrane is dissolved, components from the chambers react and expand, leading to deployment.

Abstract: A variable ram for coiled tubing comprises a pair of opposing rams, each ram having a ram body with a vertical channel formed therein; a pair of opposing pins within each ram head, the pins extending into the channel; and a toothed gripper having a hole therein sized to mount over its respective pin.

Abstract: The disclosure describes apparatuses and methods for the luminal delivery of therapeutic devices. The apparatus includes a decoupling assembly comprising a retention element, a energy-responsive element and a thermally sensitive element. The application of heat to the thermally sensitive element alters its configuration such that it no longer maintains the retention element in engagement with the therapeutic device, releasing the therapeutic device.

Abstract: A vascular occlusion device deployment system for deploying an occlusion device at a preselected site within the vasculature of a patient. The deployment system includes a pusher which has a constrictor located at the distal end portion of the pusher. The constrictor has a channel which receives a portion of the occlusion device. The constrictor has a proximal end portion and a distal end portion wherein the proximal end portion can be moved relative to the distal end portion to reduce the size of the channel. When the channel size is reduced, the constrictor grasps the portion of the occlusion device located within the channel. When it is desired to deploy the coil, the constrictor is moved in the opposite direction to increase the size of the channel and release the coil's grasp of the occlusion device.

Abstract: Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.

Abstract: An embolic coil deployment system for placing a coil at a preselected site within a vessel of the human body. The deployment system includes a heating element at the distal end of a delivery member and a heat responsive coupling for holding the coil during positioning of the coil and activation means for releasing the coil at a desired position within the vessel.

Abstract: An expandable stent having a covering which exhibits the characteristic of upon being activated by applying an agent to the covering, dissolving to expose a portion of the underlying stent. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter a selected region of the covering may be dissolved by an activating agent to permit blood to flow to adjacent vessels.

Abstract: A system and method are provided for controlling a cellular telephone account User Terminal (UT). The method includes: registering a UT with an account in a cellular telephone network; uploading a credit for cellular telephone network services to the UT from a second party; and, converting the credit to an account balance. When the UT accesses a cellular telephone network service (i.e., makes a call), then the account balance is debited. In one aspect, the method accesses a credit server funded by the second party. Then, the credit is uploaded in response to accessing the credit server. For example, the credit server may be a module embedded in the UT. Alternately, the credit server is accessed via the cellular telephone network. For example, an Internet Protocol (IP) network-connected credit server may be accessed via the cellular network.

Abstract: An expandable stent having a covering which exhibits the characteristic of being normally dissolvable in blood, but upon being activated, becomes inert to blood. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter the portion of the covering of the stent across the neck of the aneurysm is activated to become inert to blood and the balance of the covering dissolves to permit blood to flow to adjacent vessels.

Abstract: The disclosed embodiments provide systems, devices and methods for providing a reward to a user of a mobile communications device. The described embodiments, for example, may include a mobile communications device that exchanges query data and response data with a computer system over a communications network. The computer system includes an evaluation application operable to determine a predetermined reward based on, at least in part, the received response data. The response data is received by the mobile communications device from the user in response to query data presented to the user by the mobile communications device. The predetermined reward, for example, may affect an operational characteristic of the mobile communications device on the wireless network. Also disclosed are systems, devices and methods that include an outcome application, associated with the computer system, that generates an outcome determination based on, at least in part, the response data.

Abstract: The present invention is directed to providing systems and methods for remotely monitoring sites to provide real-time information which can readily permit distinguishing false alarms, and which can identify and track the precise location of an alarm. In embodiments, monitoring capabilities such as intrusion/fire detection and tracking capabilities, can be implemented through the use of multistate indicators in an interface which permits information to be transmitted using standard network protocols from a remote site to a monitoring station in near real-time. In embodiments, communications can be handed from the centrally located host monitoring station to a mobile monitoring station (for example, a laptop computer in a responding vehicle, such as a police or fire vehicle). Additional embodiments include the measurement of environmental parameters such as temperature, carbon monoxide and differential air pressure to detect, monitor and manage a fire event.

Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing light energy transferred through an optical fiber to sever a securing filament attaching the occlusion device to the deployment system, thereby releasing the occlusion device at the preselected location.

Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device.

Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employs a pusher including a gripper located at the distal end of the pusher to releasably retain a vascular occlusion device. The gripper is expanded by an expandable chemical reaction chamber so that the gripper releases the vascular occlusion device, thereby deploying the vascular occlusion device.

Abstract: A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. A stretch resistant embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. The engagement member engages a retaining ring on the embolic device. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.