Abstract: The present invention relates to a compound of formula (VII)I, or pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N—(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4? are each independently H or alkyl; or R4 and R4? together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.

Abstract: A manual breast pump comprising a pump housing defining an inlet orifice, an outlet orifice, and a pump orifice all in fluid communication with one another, the pump housing including a pump chamber, a repositionable actuator disposed within the pump chamber and repositionable within the pump chamber between a retracted position and an extended position, and a resilient band concurrently mounted to the pump housing and operatively mounted to the repositionable actuator.

Abstract: Methods and devices are disclosed for managing a resource of a communication device configured to process and communicate medical data in addition to other data. The systems and devices may implement the method, including determining whether to switch to a medical mode based on at least one signal. In response to determining to switch to the medical mode, the communication device may be switched to the medical mode. A resource status associated with a plurality of resources used by the communication device may be weighed against a medical data criticality associated with the medical data managed by the communication device. The method may include allocating a resource of the plurality of resources on a sliding priority scale. The allocating may include allocating a resource of the plurality of resources preferentially to the medical data over the other data.

Abstract: The present invention relates to a compound of formula (VII)I, or pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N—(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4? are each independently H or alkyl; or R4 and R4? together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.

Abstract: The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N—(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4? each independently H alkyl; or R4 and R4? together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.

Abstract: Embodiments of the present disclosure are directed towards a venting hatch having a base configured to couple to a storage container, wherein the base comprises a central opening configured to be exposed to an opening of the storage container, a cap coupled to the base, a seal disposed between the base and the cap, and an actuating mechanism configured to exert a biasing force on the seal to bias the seal against an annular lip of the base, wherein the actuating mechanism is disposed on an exterior surface of the cap.

Abstract: A low heavy metal (i.e. cadmium, mercury) containing calcium aluminum silicate product produced by the method of Air Classification. The method comprises using an air classification system for separating a cadmium containing calcium aluminum silicate feed stock into at least a first fraction and a second fraction. The first separation fraction contains material having an average particle size over 100 um, and the second fraction contains material having an average particle size under 100 um.

Abstract: A method for the controllable dissolution of one or more alkali metals from a vessel containing a one or more alkali metals and/or one or more partially passivated alkali metals. The vessel preferably comprising a sodium, NaK or other alkali metal-cooled nuclear reactor that has been used. The alkali metal, preferably sodium, potassium or a combination thereof, in the vessel is exposed to a treatment liquid, preferably an acidic liquid, more preferably citric acid. Preferably, the treatment liquid is maintained in continuous motion relative to any surface of unreacted alkali metal with which the treatment liquid is in contact. The treatment liquid is preferably pumped into the vessel containing the one or more alkali metals and the resulting fluid is extracted and optionally further processed. Preferably, the resulting off-gases are processed by an off-gas treatment system and the resulting liquids are processed by a liquid disposal system.

Abstract: A manual breast pump comprising a pump housing defining an inlet orifice, an outlet orifice, and a pump orifice all in fluid communication with one another, the pump housing including a pump chamber, a repositionable actuator disposed within the pump chamber and repositionable within the pump chamber between a retracted position and an extended position, and a resilient band concurrently mounted to the pump housing and operatively mounted to the repositionable actuator.

Abstract: A helmet is made by the steps of measuring the geometry of human head to map its contour, selecting an appropriately sized unfinished helmet having an oversized thick foam liner with an unfinished interior surface, collapsing selected areas of said foam liner by using an ultrasonic tool to heat said selected areas to provide a finished interior surface having a predetermined shape conforming to said contour of said human head. The helmet comprises a helmet shell with an interior-facing liner having selected areas of collapsed foam which provide an interior facing foam liner surface which conforms to a predetermined geometry of a human head.

Abstract: Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.

Abstract: The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N—(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and R2 are each independently H, alkyl or cycloalkyl; R4 and R4? each independently H alkyl; or R4 and R4? together form a spiro cycloalkyl group; R19 is H, alkyl, aryl or a cycloalkyl group; R6 is OR8 or halogen; and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.

Abstract: A method and system includes transmitting a publishing request from a first location, over a network to a central processor. The publishing request at least includes information for electronic publication, where the transmitting adjusts, by a first amount, a first account associated with a first user making the publishing request. At an at least one second location, over the network from the central processor, the publishing request is received for at least one user to accept the request and electronically publish published information including the information. At the at least one second location, over the network from the central processor, validation of the publication is received, where at least a second account associated with the at least one user is credited by a second amount as a result of validation of the publication, wherein a ratio of the first amount and the second amount is a predetermined value.

Abstract: A route-based connector for interconnecting a first drug delivery component with a second drug delivery component having a mating route-based connector. The connector has a geometrically-coded shape corresponding to a drug delivery route. A set of route-based connectors may be provided with plural geometrically-coded shapes that are each assigned to a corresponding drug delivery route according to a key. The connectors may also be color coded to designate the delivery route. A port adapter may be provided having a flow control valve for stopping and starting a flow of medication through the adapter. The port adapter may include a universal connector on one end thereof and a route-based connector on another end thereof that has a geometrically coded shape that allows the port adapter to connect to one of the route-based connectors. Machine readable or light emitting route identifiers may be provided on the connectors or on components associated therewith.

Abstract: A vascular occlusion device that includes an inner embolic member at least partially covered by an expandable generally tubular mesh. The expandable tubular mesh typically comprises a unitary wall with apertures through the wall to assist in the expansion of the generally tubular mesh.