Abstract: An expandable stent having a covering which exhibits the characteristic of upon being activated by applying an agent to the covering, dissolving to expose a portion of the underlying stent. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter a selected region of the covering may be dissolved by an activating agent to permit blood to flow to adjacent vessels.

Abstract: An expandable stent and delivery system is provided for enhancing luminal dilation of a blood vessel and treating aneurysms. The delivery system includes proximal, intermediate and distal cylindrical members disposed on and spaced apart along an elongated core member such that first and second gaps are formed. The expandable stent includes anchor members which align with the gaps. The expandable stent is mounted on the intermediate cylindrical member, and the anchor members are disposed within the gaps thereby locking the stent onto the core member.

Abstract: The invention relates to a role-based access control system, including a role definition system for defining roles to be sets of permissions on individual resources thus forming role instances, respectively; and a super role definition system for defining at least one super role by grouping a set of role instances into one super role, wherein the one super role contains all permissions contained in the grouped resource instances. Furthermore, the present invention deals with an appropriate method, a computer program and a computer program product.

Abstract: The present invention relates to a medical device for placement at a predetermined location within a passageway of the human body, and more particularly, relates to a flexible embolization device which may be delivered by a catheter to a pre-selected position within a blood vessel to thereby embolize a blood vessel or a blood vessel defect, such as an aneurysm or fistula. Specifically, the embolization device comprises an elongated coil having a lumen, the coil and lumen being at least partially embedded in an elongated foam member comprising, in some embodiments, a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior.

Abstract: An expandable stent and delivery system therefor is provided for treating vascular diseases such as partially occluded blood vessels and aneurysms. The delivery system includes proximal, intermediate and distal cylindrical members disposed about an elongated core member. The proximal, intermediate, and distal cylindrical members are spaced apart such that first and second gaps are formed. The expandable stent includes anchor members which are formed by winding a radiopaque coil onto a threaded portion of a strut member of the expandable stent. The expandable stent is mounted on the intermediate cylindrical member with the anchor members disposed within the gaps between the cylindrical members. A deployment catheter is used to compress and constrain the stent about the intermediate cylindrical member to thereby interlock the stent onto the core member.

Abstract: A method as provided for occluding the vasculature of a patient. The method comprises the steps of providing a plurality of embolic coils having a textured surface. The embolic coils are introduced into the patient's vasculature. In this manner, the textured surface provides improved platelet adhesion compared to a non-textured surface, to promote clotting. In the illustrative embodiment, the embolic coil comprises a platinum-tungsten alloy wire and the texturing is performed by abrasion or sandblasting to provide substantially uniform roughness comprising pockets having diameters of about 0.125 microns to about fifty microns and depths of about 0.25 microns to about twenty microns.

Abstract: A very small diameter intravascular stent device which may be used to occlude or partially occlude an aneurysm in the human brain which is comprised of a thin-walled skeletal cylindrical tube formed of S-shaped or sinusoidal elements which, when compressed, nest tightly with each other.

Abstract: The present invention provides an apparatus for sensing biometric information in a finger with piezo ceramic elements. In one embodiment, the apparatus includes an array of discrete piezo ceramic elements and filler. The array of discrete piezo ceramic elements is responsive to acoustic characteristics of parts of the finger. The filler is distributed between the discrete piezo ceramic elements and provides acoustic attenuation and electric isolation between the discrete piezo ceramic elements. A protective layer can receive a ridge pattern of the finger positioned proximate to the array. Air in valleys between ridges of the ridge patten of the finger acts as an acoustic barrier. A backing layer (air or foam) can also be provided.

Abstract: The present invention is directed to providing systems and methods for remotely monitoring sites to provide real time information which can readily permit distinguishing false alarms, and which can identify and track the precise location of an alarm. In embodiments, monitoring capabilities such as intrusion/fire detection and tracking capabilities, can be implemented through the use of multistate indicators in a novel interface which permits information to be transmitted using standard network protocols from a remote site to a monitoring station in real-time. In embodiments, communications can be handed from the centrally located host monitoring station to a mobile monitoring station (for example, a laptop computer in a responding vehicle, such as a police or fire vehicle). Additional embodiments include high, low, and rate-of-change alarms; chromagraphic representation of the value of an environmental or other parameter measured in a space; and detection and location of portable interface devices in a space.

Abstract: With the present invention for conveying information regarding an emergency, an alarm system can be notified of number, condition, location, and/or need of assistance of occupants within a building during an emergency. Building occupants can be informed of safe paths along which to proceed during an emergency. Further, a command workstation, such as a fire command workstation, can be integrated into an alarm system having multiple functions, detection devices, and voice communication capabilities.

Abstract: A vascular occlusive device which includes an embolic support structure, such as an embolic coil, having an elastomeric, bioresorbable coating disposed on the surface of the support structure which serves to promote controlled tissue growth into the embolic support structure.

Abstract: The compound 1-(indole-6-carbonyl-D-phenylglycinyl)-4-(1-methylpiperidin-4-yl)piperazine and physiologically-tolerable salts thereof are factor Xa inhibitors useful for the treatment of thrombotic disorders.

Abstract: The antibiotic drug clindamycin is provided as a crystalline free base. Three polymorphic/pseudopolymorphic forms of crystalline clindamycin free base are disclosed. Also provided are pharmaceutical compositions comprising crystalline clindamycin free base. Processes for preparing crystalline clindamycin free base and compositions thereof are also provided along with methods for treating medical conditions with the pharmaceutical compositions.

Abstract: Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Abstract: A vascular occlusive device which includes a support structure and a bioactive coating disposed onto the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive agent and bodily fluids until the outer barrier is activated by applying an external agent to the outer barrier.

Abstract: A medial device, such as a vascular occlusive device, which includes a support element having a compound disposed thereon which stimulates the production of vascular endothelial growth factors, and an outer barrier coating which serves to prevent a reaction between the compound and bodily fluids until the outer barrier is dissolved by applying an external agent to the outer barrier.

Abstract: A medial device such as a vascular occlusive device which includes a support structure and a bioactive expansible coating disposed on the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive expansible coating and bodily fluids until the outer barrier is activated and removed by applying an external agent to the outer barrier thereby permitting expansion of the bioactive coating.

Abstract: A medial device such as a vascular occlusive device which includes a support structure and a bioactive expansible coating disposed on the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive expansible foam coating and bodily fluids until the outer barrier is activated and removed by applying an external agent to the outer barrier thereby permitting expansion of the bioactive foam coating.

Abstract: A medial device which includes a support structure and a bioactive coating disposed onto the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive agent and bodily fluids until the outer barrier is activated by applying an external agent to the outer barrier.

Abstract: Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.