Abstract: The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: An apparatus, which may be a tillage apparatus may have a flexible frame. The frame may be made from transverse and longitudinal open members. The frame may support ground engagers and may be supported on wheel assemblies. The ground engagers may be connected to a spring trip mechanism. The ground engagers may be mounted to open members of the frame with a clamping style mechanism. The clamp mechanism may include wedge devices. The frame may be lowered and raised relative to wheels of the wheel assemblies with a lift mechanism. One row of ground engagers may be raised or lowered relative to the frame independent of another row of ground engagers. An anti-skid or skew control system may be employed in association with the independent height adjustment of one row of ground engagers. A system may be provided to maintain and control the height of a tow hitch forming part of the apparatus.

Abstract: Systems and methods for the display and navigation of a social network or set forth. According to one embodiment a method comprising identifying a first profile in a social network, identifying associated profiles associated with the first profile, ranking the associated profiles, wherein ranking is not based exclusively on a degree of separation, and outputting the associated profiles based at least in part on the ranking is set forth. According to another embodiment a method comprising identifying a user profile, identifying a member profile, determining an association path for the user profile and the member profile, and outputting the association path is set forth.

Abstract: The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

Abstract: A touch-based gesture interface is provided. An initial point of contact for a touch made on a touch-screen surface is associated with a reference value. If the initial contact is sustained before release, directional axis changes for the touch are noted until the contact is released to identify a gesture-based touch input. The directional axis changes associated with the gesture-based touch input are translated into a key entry based on the directional axis changes made relative to the reference value. If the initial contact is released with no directional axis movement/changes, the key entry is assigned to the reference value for the gesture-based touch input. In an embodiment, two successive touches with no directional axis movement/changes made within a threshold period of time is identified as a cancel key.

Abstract: A locomotive engine control system includes one or more processors operably connected to fuel supply devices. The fuel supply devices are configured to supply fuel into different corresponding cylinders of an engine. The one or more processors are configured to monitor a fuel quantity injected into the cylinders of the engine before and after communication of an overfuel control signal. The overfuel control signal commands the fuel supply device corresponding to a first cylinder of the cylinders to supply excess fuel into the first cylinder. Responsive to the fuel quantity that is monitored not decreasing after the communication of the overfuel control signal, the one or more processors are configured to determine that the fuel supply device corresponding to the first cylinder is defective, and may generate one or more control signals indicative of the fuel supply device corresponding to the first cylinder being defective.

Abstract: Sensing systems and methods are provided for compensating for offset and gain changes. A sensing system includes a magnetic element, a current sensing arrangement to provide a current measurement signal influenced by a flux induced in the magnetic element, an oscillator arrangement to provide a reference oscillating current signal configured to induce an oscillating flux in the magnetic element, and a compensation arrangement coupled the current sensing arrangement to adjust the current measurement signal to compensate for gain changes in the measurement signal output and provide a compensated current measurement based at least in part on the adjusted measurement signal and the reference oscillating current signal. The oscillating flux influences the current measurement signal output by the current sensing arrangement.

Abstract: In a packaging material that is, or includes, a laminate, the laminate includes first and second webs that are joined to one another. The first web includes a metallic layer on a second layer. The metallic layer is positioned between the second layer and the second web. Indicium is defined in at least the metallic layer. The packaging material is configured so that the indicium is visible from a first side of the packaging material, and the indicium is typically not visible from a second side of the packaging material. The indicium can be at least partially defined by holes in the metallic layer. The visibility of the indicium may be enhanced by the laminate including material that is a different color than the metallic layer, and the different color being at least partially visible through the indicium.

Abstract: The present invention relates to compounds of formula I: in which Y1, Y2, Y3, Y4 R1, R2, R4a, R4b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A system and method include presentation of a plurality of virtual objects to a first user, reception, from the first user, of a command to associate a voice annotation with one of the plurality of virtual objects, reception of audio signals of a first voice annotation from the first user, and storage the received audio signals in association with metadata indicating the first user and the one of the plurality of virtual objects.

Abstract: The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: An apparatus and method are provided for storing bounded pointers. One example apparatus comprises a storage comprising storage elements to store bounded pointers, each bounded pointer comprising a pointer value and associated attributes including at least range information, and processing circuitry to store a bounded pointer in a chosen storage element. The storing process comprises storing in the chosen storage element a pointer value of the bounded pointer, and storing in the storage element the range information of the bounded pointer, such that the range information indicates both a read range of the bounded pointer and a write range of the bounded pointer that differs to the read range. The read range comprises at least one memory address for which reading is allowed when using the bounded pointer, and the write range comprises at least one memory address to which writing is allowed when using the bounded pointer.

Abstract: Disclosed are systems and methods for completing a transaction using a shelf and interactive tablet. The systems and methods may include receiving, at an interactive tablet comprising a processor, a captured image associated with an item; identifying, by the interactive tablet, a known image of the item based on the captured image of the item; and retrieving, by the interactive tablet, product information associated with the item based on the known image of the item.

Abstract: An apparatus and method are provided for controlling access to a space using an improved locking apparatus. The locking apparatus includes a central member having an actuator, a shaft connected to the actuator, at least one cam attached to the shaft, a control circuit configured to control operations of the locking apparatus, and a lifting member configured to be raised or lowered according to a command position. A method is provided for operating a mounted locking apparatus in a locked or unlocked state.

Abstract: A method, computer program product, and computing system for receiving content from a third-party. The content may be processed to predict the disclosure of sensitive information. The sensitive information may be obscured from a platform user, where the third-party may be a customer and the platform user may be a customer service representative.

Abstract: A touch-based gesture interface is provided. An initial point of contact for a touch made on a touch-screen surface is associated with a reference value. If the initial contact is sustained before release, directional axis changes for the touch are noted until the contact is released to identify a gesture-based touch input. The directional axis changes associated with the gesture-based touch input are translated into a key entry based on the directional axis changes made relative to the reference value. If the initial contact is released with no directional axis movement/changes, the key entry is assigned to the reference value for the gesture-based touch input. In an embodiment, two successive touches with no directional axis movement/changes made within a threshold period of time is identified as a cancel key.

Abstract: A harvesting header is disclosed that comprises a support frame and a crop moving apparatus supported on the support frame and operable for moving cut crop material to a transfer region. The header also has a cavity located proximate and lower than an output end of the crop moving apparatus. The header has a crop flow assistance device having a plurality of transversely spaced elements that extend generally longitudinally at least partially above the cavity, and which are operable to assist cut crop material in being transferred from the output end of the moving apparatus to flow over the cavity. The cavity may be operable to receive rocks and/or debris carried by the conveyor to the transfer region. The header may include a rock trap located in the transfer region the cavity being part of the rock trap and may be operable to receive rocks and/or debris carried by the conveyor to the transfer region.

Abstract: A computer-implemented method according to one embodiment includes identifying a plurality of documents associated with a predetermined subject, where each of the plurality of documents contains textual data, analyzing the textual data of each of the plurality of documents to identify one or more categories within the plurality of the documents, and returning the one or more categories identified within the plurality of the documents.