Abstract: The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxynojirimycin and enzyme replacement therapy for the treatment of Pompe disease. The presently disclosed subject matter further provides a dosing regimen and administration schedule for the use of 1-deoxynojirimycin hydrochloride and alglucosidase alfa for the treatment of Pompe disease.

Abstract: A network access manager controls access to a network interface according to a set of access control instructions specifying permissible and impermissible addresses and domains on a network. The network access manager establishes a graylist of addresses based on a domain request that is associated with a whitelisted domain that is accessed via a blacklisted address. When a request to establish a connection is received directed to a graylisted address, the connection is permitted to establish and the connection is added to a session graylist. When a session data transfer packet is received, if the session corresponds to a session on the session graylist, the session data transfer packet is examined to determine if it matches a whitelisted domain, in which case the session is associated with a session whitelist and permitted access to the network. The access control instructions may be automatically updated from a trusted access control management system.

Abstract: A camera module includes a body having recesses in a first datum surface. A filleted edge may join the recesses to the first datum surface. An image sensor is coupled to the body at a known distance from the first datum surface. A movable lens mechanism includes a fixed portion and a movable portion. The fixed portion is coupled to the body. The movable portion includes a lens assembly and protrusions arranged to fit within the recesses in the first datum surface and to define a second datum surface. A resilient stop plate covers the recesses in the first datum surface with an elastic sheet material. A spring may hold the protrusions in contact with the resilient stop plate when the movable lens mechanism is unpowered. The resilient stop plate may include a rigid support plate coupled to the body by heat staking. The elastic sheet material may be viscoelastic.

Abstract: A method, system, and computer program product for parking reservation that encourages car-pooling are provided in the illustrative embodiments. A processor, at a first mobile data processing system representing an automobile, receives an input to create a reservation for a parking location. A second mobile data processing system is detected, wherein the second mobile data processing system is within a threshold distance of the first mobile data processing system. A determination is made whether a movement of the second mobile data processing system relative to the first mobile data processing system is less than a threshold measure of the movement. Responsive to the determining being affirmative, a qualifier is applied to the reservation to obtain a benefit in the reservation, wherein the qualifier accrues a benefit to the reservation.

Abstract: A method, system, and computer program product for an environmentally-friendly parking reservation system are provided in the illustrative embodiments. A computer receives a request to make a reservation for parking a vehicle in a parking area. A parking location in the parking area is selected in an application, forming a selection. The computer modifies the selection based on a qualifier in the request, the qualifier indicating an environmentally-friendly aspect of the vehicle. The computer generates a response, the response identifying the parking location.

Abstract: A camera module has an image sensor and a lens assembly that includes a lens barrel having a first cylindrical portion that includes an externally threaded portion and a second cylindrical portion that has a larger diameter than the externally threaded portion. A lens moving mechanism includes a movable sleeve having internal threads that receive the externally threaded portion of the lens assembly. The lens moving mechanism is coupled to the image sensor such that the second cylindrical portion of the lens assembly is closest to the image sensor. The camera module is assembled by inserting the lens assembly into the lens moving mechanism from the side closest to the image sensor. An installation tool may engage the second cylindrical portion to rotate the lens assembly and engage the threaded portions. Features may be provided to retain the lens assembly in the lens moving mechanism before joining the threaded portions.

Abstract: Response delay associated with a state-based client-server application can be reduced with utilization of an application state server-side cache. A server caches data for a set of one or more possible states of a client-server application that may follow a current state of the application. The server rapidly responds to a client request with data that corresponds to an appropriate new state of the application in accordance with the application state server-side cache. The server determines that the application will transition to the appropriate new state from the current state of the application with the application state server-side cache based, at least in part, on an operation indicated by the client request.

Abstract: The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxygalactonojirimycin and enzyme replacement therapy for the treatment of Fabry disease. The presently disclosed subject matter further provides a dosing regimen and administration schedule for the use of migalastat hydrochloride and agalsidase for the treatment of Fabry disease.

Abstract: A camera module includes a body having recesses in a first datum surface. A filleted edge may join the recesses to the first datum surface. An image sensor is coupled to the body at a known distance from the first datum surface. A movable lens mechanism includes a fixed portion and a movable portion. The fixed portion is coupled to the body. The movable portion includes a lens assembly and protrusions arranged to fit within the recesses in the first datum surface and to define a second datum surface. A resilient stop plate covers the recesses in the first datum surface with an elastic sheet material. A spring may hold the protrusions in contact with the resilient stop plate when the movable lens mechanism is unpowered. The resilient stop plate may include a rigid support plate coupled to the body by heat staking. The elastic sheet material may be viscoelastic.

Abstract: A camera module has an image sensor and a lens assembly that includes a lens barrel having a first cylindrical portion that includes an externally threaded portion and a second cylindrical portion that has a larger diameter than the externally threaded portion. A lens moving mechanism includes a movable sleeve having internal threads that receive the externally threaded portion of the lens assembly. The lens moving mechanism is coupled to the image sensor such that the second cylindrical portion of the lens assembly is closest to the image sensor. The camera module is assembled by inserting the lens assembly into the lens moving mechanism from the side closest to the image sensor. An installation tool may engage the second cylindrical portion to rotate the lens assembly and engage the threaded portions. Features may be provided to retain the lens assembly in the lens moving mechanism before joining the threaded portions.

Abstract: The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.

Abstract: A camera module has an image sensor and a lens assembly that includes a lens barrel having a first cylindrical portion that includes an externally threaded portion and a second cylindrical portion that has a larger diameter than the externally threaded portion. A lens moving mechanism includes a movable sleeve having internal threads that receive the externally threaded portion of the lens assembly. The lens moving mechanism is coupled to the image sensor such that the second cylindrical portion of the lens assembly is closest to the image sensor. The camera module is assembled by inserting the lens assembly into the lens moving mechanism from the side closest to the image sensor. An installation tool engages the second cylindrical portion to rotate the lens assembly and engage the externally threaded portion of the lens assembly with an internally threaded portion of a movable sleeve in the lens moving mechanism.

Abstract: A modification method and system. The method includes retrieving by a computer processor of a computing system a list of features and plug-ins associated with an application. The features include features version metadata and the plug-ins include plug-ins version metadata. The computer processor compares features source code associated with the features with previous versions of associated source code. The computer processor generates modified features version metadata associated with the features version metadata. The modified features version metadata includes updated version labels differing from previous version labels of the previous versions of associated source code. The features are assembled into an application.

Abstract: Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.

Abstract: An optical navigation device includes an optical transmission element, operable in use to transmit light from an illumination source to a sensor via a mousing surface, and a housing unit. The optical transmission element may have an alignment shaft. Ideally the optical transmission element and housing unit are assembled to a substrate by snap-fit. The alignment shaft ensures that the optics are properly aligned to the substrate and the light source and sensor thereon.

Abstract: An image generation method and system. The method includes receiving by a computing apparatus from a video recording device attached to a backside of a video monitor connected to the computing apparatus, a video data stream comprising a first video image of an input device connected to the computing apparatus and a second video image of a users hands enabling switches on the input device. An input device image associated with the input device is displayed. The computing apparatus super-imposes and displays a hand image associated with the user's hands over the input device image. The computing apparatus adjusts a brightness of the hand image such that the input device image is visible through the hand image.

Abstract: A computer readable storage medium comprises executable instructions to provide a workspace for a user to define an expression with expression components from a graphical palette associated with the workspace. Placeholders are indicated in the workspace for the expression components to be added by the user. The placeholders are associated with a data type. The data type is enforced for each placeholder. A structured visual representation of the expression is provided on the workspace.

Abstract: Embodiments for dynamically generating a portal site map may include determining a root node of a navigational construct of a portal site, where the root node has one or more child nodes. Embodiments may further include recursively crawling through the one or more child nodes of the root node to discover a composition subtree for at least one of the child nodes, the composition subtree comprising information relating to one or more portlets associated with at least one of the child nodes. Embodiments may further include generating a portal site map having an indication of the one or more child nodes and an indication of the one or more portlets associated with at least one of the child nodes. Further embodiments may include generating a portlet response based on the generated portal site map.

Abstract: The invention relates to the use of an Raf inhibitor for the manufacture of pharmaceutical compositions for the treatment of thyroid cancer, more specifically papillary thyroid cancer (PTC); the use of a Raf inhibitor in the treatment of thyroid cancer, more specifically PTC; a method of treating warm-blooded animals including mammals, especially humans, suffering from thyroid cancer, more specifically PTC, by administering to a said animal in need of such treatment a dose effective against said disease of an Raf inhibitor. The invention also relates to the use of a Raf inhibitor in combination with a platin compound for the treatment of thyroid cancer, more specifically papillary thyroid cancer.

Abstract: An image generation method and system. The method includes receiving by a computing apparatus from a video recording device attached to a backside of a video monitor connected to the computing apparatus, a video data stream comprising a first video image of an input device connected to the computing apparatus and a second video image of a users hands enabling switches on the input device. An input device image associated with the input device is displayed. The computing apparatus super-imposes and displays a hand image associated with the user's hands over the input device image. The computing apparatus adjusts a brightness of the hand image such that the input device image is visible through the hand image.