Abstract: Indexed collar clamps allow for fast and easy adjustment of an associated telescoping stand, while preventing various underlying components from becoming dislodged from their respective positions over time. A telescoping stand may include an inner tube and an outer tube partially overlapping the inner tube. An overlapping end of the outer tube includes a compliance cut. A bushing is positioned between the inner tube and the outer tube and adjacent the compliance cut. The bushing includes a protrusion that indexes the bushing to an aperture in the outer tube. An indexed collar clamp is positioned over the outer tube and also adjacent the compliance cut. The protrusion from the bushing further indexes the bushing to a slot in the indexed collar clamp.

Abstract: The clamping support heads disclosed herein provide a clampable mouth having jaws that can securely hold and permit movement of a variety of different size and/or shape objects. The objects may be quickly attached and quickly removed from the clamping support heads. A repositioning clutch allows for rotational repositioning of a clamped object. The repositioning clutch may include a clutch body attached to a stem of a stand, a friction ring seated to a clutch body, a bearing plate sharing a bearing interface with the friction ring, a clutch shaft extending through the clutch body, the friction ring, and the bearing plate to a terminal end, and a clutch adjustment handle screwed onto the terminal end of the clutch shaft. Rotation of the clutch adjustment handle adjusts compression force on the bearing interface between the friction ring and the bearing plate to secure or release the object from rotation.

Abstract: Systems and methods are described herein for a prosthetic device that includes a rigid outer shell socket with an inner surface contour. A prosthetic insert socket is manufactured via a manufacturing process, such as three-dimensional printing, to have an outer contour that corresponds to the inner surface contour of the premade outer shell socket. The prosthetic insert socket is manufactured to have an inner contour that corresponds to a residual limb surface contour of a patient.

Abstract: Disclosed are anti-angiogenic agents that target Pfn1:actin interaction. Also disclosed are compounds for treating ocular diseases or conditions. Further disclosed are compounds for treating cancer.

Abstract: Systems and methods are described herein for a prosthetic device that includes a premade outer shell socket with an inner surface contour. A prosthetic insert socket is manufactured via a manufacturing process, such as three-dimensional printing, to have an outer contour that corresponds to the inner surface contour of the premade outer shell socket. The prosthetic insert socket is manufactured to have an inner contour that corresponds to a residual limb surface contour of a patient.

Abstract: The present disclosure provides methods of preparing a biological specimen for imaging analysis, comprising fixing and clearing the biological specimen and subsequently analyzing the cleared biological specimen using microscopy. Also included are methods of quantifying cells, for example, active populations of cells in response to a stimulant. The present disclosure also provides devices for practicing the described methods. A flow-assisted clearing device provides rapid clearing of hydrogel-embedded biological specimens without the need of specialized equipment such as electrophoresis or perfusion devices.

Abstract: The present disclosure provides methods of preparing a biological specimen for imaging analysis, comprising fixing and clearing the biological specimen and subsequently analyzing the cleared biological specimen using microscopy. Also included are methods of quantifying cells, for example, active populations of cells in response to a stimulant. The present disclosure also provides devices for practicing the described methods. A flow-assisted clearing device provides rapid clearing of hydrogel-embedded biological specimens without the need of specialized equipment such as electrophoresis or perfusion devices.

Abstract: Provided herein are devices, methods, and systems for in situ gene sequencing of a target nucleic acid in a cell in an intact tissue. Methods of screening a candidate agent to determine whether the candidate agent modulates gene expression of a nucleic acid in a cell in an intact tissue are also provided herein.

Abstract: An ion source. The ion source may include a plasma chamber to house a plasma, and an extraction assembly, disposed along a side of the plasma chamber, and comprising at least one extraction aperture. The ion source may further include an antenna assembly, extending through the plasma chamber, along a first axis. The antenna assembly may include a dielectric enclosure, a plurality of conductive antennae, extending along the first axis within the dielectric enclosure.

Abstract: Provided are compositions, including products of manufacture and kits, and methods, for remotely-controlled and non-invasive manipulation of intracellular nucleic acid expression, genetic processes, function and activity in live cells such as a T cell, a primary T cell, a B cell, a monocyte, a macrophage, a dendritic cell or a natural killercell in vivo, for example, including activating, adding functions or changing or adding specificities for an immune cell, for monitoring physiologic processes, for the correction of pathological processes and for the control of therapeutic outcomes. Provided are tamoxifen-gated photoactivatable split-Cre recombinase optogenetic systems, called TamPA-Cre, that feature high spatiotemporal control to control or alter cell activities in vivo, for example, to limit the activity of a Chimeric Antigen Receptor (CAR)-expressing cell such as an immune cell and its activity at a tumor site for immunotherapy applications.

Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Abstract: Embodiments herein include a transparent halo assembly for reducing an amount of sputtered material to minimize particle defects impacting a workpiece. In some embodiments, a halo assembly may include a first halo arranged around a semiconductor workpiece, and a mounting assembly coupling the first halo to a roplat. The first halo may include a first side opposite a second side, and a first end opposite a second end, wherein the first side is operable to receive an ion beam from an ion source. The first halo may further include a plurality of apertures extending between the first and second sides, wherein the plurality of apertures permit passage of a portion of the ion beam to pass therethrough, towards the mounting assembly. In some embodiments, the halo assembly may include a second halo positioned proximate the first halo, and a third halo disposed between the first halo and the mounting assembly.

Abstract: An articulating mower deck system. The system is adapted to disable power to a blade associated with the wing deck section before the wing deck section begins to lift—from an operating position toward a folded position—yet does not interfere with blade operation when the wing deck section floats relative to a center deck section during normal operation of the deck. Articulating decks of modular construction are also provided, allowing assembly of multiple deck widths with a minimum of modular deck sections.

Abstract: A method for altering a characteristic of the ground. The method comprises the steps of preparing a lignocellulosic material, suspending the lignocellulosic material in a slurry to create a lignocellulosic slurry, The method further includes the step of injecting the lignocellulosic slurry below the surface of the ground into a subterranean aperture. The method also comprises the placement of anchoring devices in the ground to alter at least one force experienced by the ground so that the shape of the subterranean aperture into which the solids are transported is altered.

Abstract: Imipridones has been found to selectively modulate Class A G protein-coupled receptors (GPCRs), such as the D2-like subfamily of dopamine receptors, and to be useful for the treatment of conditions and disorders in need of such modulation, such as cancers, psychiatric disorders, and bacterial infections. In addition, methods of identifying whether a subject having these condition, is likely to be responsive to a treatment regimen, such as administration of an imipridone, are provided. Furthermore, methods of assessing the effectiveness of a treatment regimen, such as administration of an imipridone, monitoring, or providing a prognosis for a subject with these condition are also provided.

Abstract: Systems and methods are described herein for a prosthetic device that includes a premade outer shell socket with an inner surface contour. A prosthetic insert socket is manufactured via a manufacturing process, such as three-dimensional printing, to have an outer contour that corresponds to the inner surface contour of the premade outer shell socket. The prosthetic insert socket is manufactured to have an inner contour that corresponds to a residual limb surface contour of a patient.

Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.

Abstract: A semiconductor device including stacked structures. The stacked structures include at least two chalcogenide materials or alternating dielectric materials and conductive materials. A liner including alucone is formed on sidewalls of the stacked structures. Methods of forming the semiconductor device are also disclosed.

Abstract: In order for hydraulic disk brakes to function properly over time, associated brake pads are changed periodically. In order to exchange old brake pads for replacement brake pads, a disk brake may require pushing back the brake pistons within a brake caliper body in order to make room for installation of replacement pads. Current tools and methods typically require removal of a wheel from a vehicle, removal of a brake rotor from the wheel, and/or removal of the brake caliper body from a rotor. The presently disclosed caliper piston tool allows brake pads to be replaced without dismantling various components of the vehicle, resulting in significant time and cost savings as well as convenience for do-it-yourself and professional mechanics alike.