Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR FILLING VIALS WITH GASES
    Publication number: 20250009910
    Abstract: The invention provides novel apparatus and methods for efficiently and accurately filling vials with gaseous materials such as a fluorinated gas, with or without concomitantly filling the vials with another liquid or solid material.
    Type: Application
    Filed: August 16, 2024
    Publication date: January 9, 2025
    Inventors: Evan C. Unger, Daniel C. Evans, Varadarajan Ramaswami
  • ISO-OSMOTIC AND NEAR ISO-OSMOTIC OXYGEN THERAPEUTIC FORMULATIONS AND METHODS THEREOF
    Publication number: 20240390290
    Abstract: The invention provides novel iso-osmotic or near iso-osmotic formulations of fluorocarbon emulsions that are useful as oxygen therapeutics, for example, for treating sickle cell disease and related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: April 28, 2024
    Publication date: November 28, 2024
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • NOVEL FLUOROCHEMICAL CARDIAC RESUSCITATION
    Publication number: 20240277627
    Abstract: The invention provides pharmaceutical compositions and dosage forms of fluorocarbon emulsions that are useful for treating blocked blood flow, such as from cardiac arrest, as well as methods of preparation and use thereof.
    Type: Application
    Filed: September 1, 2023
    Publication date: August 22, 2024
    Inventor: Evan C. UNGER
  • SYSTEMS AND METHODS FOR FILLING VIALS WITH GASES
    Publication number: 20240252692
    Abstract: The invention provides novel apparatus and methods for efficiently and accurately filling vials with gaseous materials such as a fluorinated gas, with or without concomitantly filling the vials with another liquid or solid material.
    Type: Application
    Filed: February 8, 2024
    Publication date: August 1, 2024
    Inventors: Evan C. Unger, Daniel C. Evans, Varadarajan Ramaswami
  • FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
    Publication number: 20240245773
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Application
    Filed: January 1, 2024
    Publication date: July 25, 2024
    Inventor: Evan C. Unger
  • FLUOROCARBON COMPOSITIONS AND METHODS FOR ENHANCING IMMUNOTHERAPY
    Publication number: 20240207199
    Abstract: The invention provides pharmaceutical compositions of fluorocarbon emulsions and methods thereof that are useful for treating cancer, in particular in enhancing the effect of immunotherapy in cancer treatment.
    Type: Application
    Filed: April 29, 2022
    Publication date: June 27, 2024
    Inventor: Evan C. Unger
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES
    Publication number: 20240148914
    Abstract: The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: July 8, 2023
    Publication date: May 9, 2024
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Iman Daryaei, Maria Fernanda Acosta
  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 11857627
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: November 25, 2022
    Date of Patent: January 2, 2024
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • Adjusting particle size in fluorocarbon nanoemulsions
    Patent number: 11826319
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: November 28, 2023
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund Marinelli
  • DODECAFLUOROPENTANE EMULSION AS A STROKE AND ISCHEMIA THERAPY
    Publication number: 20230190890
    Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.
    Type: Application
    Filed: December 10, 2022
    Publication date: June 22, 2023
    Inventors: William Culp, Robert Skinner, Evan C. Unger
  • FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
    Publication number: 20230144544
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Application
    Filed: November 25, 2022
    Publication date: May 11, 2023
    Inventor: Evan C. Unger
  • ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY
    Publication number: 20230041342
    Abstract: The invention provides novel compounds, compositions and formulations of liposomes, microbubbles and/or nanodroplets, and emulsions thereof, that are useful in delivery of various nucleic acids and genes (e.g., single stranded RNA, DNA, si-RNA and CRISPR constructs), as well as methods of preparation and use thereof including methods of imaging and gene delivery using ultrasound activation.
    Type: Application
    Filed: January 7, 2021
    Publication date: February 9, 2023
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Maria F. Acosta, Dillon Hanrahan
  • Dodecafluoropentane emulsion as a stroke and ischemia therapy
    Patent number: 11571467
    Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 7, 2023
    Assignee: BioVentures, LLC
    Inventors: William Culp, Robert Skinner, Evan C. Unger
  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 11534492
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: February 7, 2021
    Date of Patent: December 27, 2022
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • COMPOSITIONS OF FLUOROCARBON NANOEMULSION, AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20220401364
    Abstract: The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.
    Type: Application
    Filed: April 15, 2022
    Publication date: December 22, 2022
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES
    Publication number: 20220305143
    Abstract: The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 29, 2022
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Iman Daryaei, Maria Fernanda Acosta
  • Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
    Patent number: 11304899
    Abstract: The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: April 19, 2022
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • Phospholipid composition and microbubbles and emulsions formed using same
    Patent number: 11160885
    Abstract: A composition, and method thereof, for stabilizing a fluorocarbon emulsion includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid.
    Type: Grant
    Filed: January 26, 2019
    Date of Patent: November 2, 2021
    Assignee: Microvascular Therapeutics LLC
    Inventors: Evan C. Unger, Daniel C. Evans
  • COMPOSITIONS AND METHODS FOR TARGETED CONTRAST AGENTS FOR MOLECULAR IMAGING
    Publication number: 20210321985
    Abstract: The invention provides novel targeted particles as contrast agents for use in molecular imaging of vulnerable plaque, and methods of preparation and application thereof.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 21, 2021
    Inventors: Terry Matsunaga, Craig C. Weinkauf, Evan C. Unger, Edmund R. Marinelli
  • FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
    Publication number: 20210260190
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Application
    Filed: February 7, 2021
    Publication date: August 26, 2021
    Inventor: Evan C. Unger