Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES
    Publication number: 20240148914
    Abstract: The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: July 8, 2023
    Publication date: May 9, 2024
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Iman Daryaei, Maria Fernanda Acosta
  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 11857627
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: November 25, 2022
    Date of Patent: January 2, 2024
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • Adjusting particle size in fluorocarbon nanoemulsions
    Patent number: 11826319
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: November 28, 2023
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund Marinelli
  • DODECAFLUOROPENTANE EMULSION AS A STROKE AND ISCHEMIA THERAPY
    Publication number: 20230190890
    Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.
    Type: Application
    Filed: December 10, 2022
    Publication date: June 22, 2023
    Inventors: William Culp, Robert Skinner, Evan C. Unger
  • FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
    Publication number: 20230144544
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Application
    Filed: November 25, 2022
    Publication date: May 11, 2023
    Inventor: Evan C. Unger
  • ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY
    Publication number: 20230041342
    Abstract: The invention provides novel compounds, compositions and formulations of liposomes, microbubbles and/or nanodroplets, and emulsions thereof, that are useful in delivery of various nucleic acids and genes (e.g., single stranded RNA, DNA, si-RNA and CRISPR constructs), as well as methods of preparation and use thereof including methods of imaging and gene delivery using ultrasound activation.
    Type: Application
    Filed: January 7, 2021
    Publication date: February 9, 2023
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Maria F. Acosta, Dillon Hanrahan
  • Dodecafluoropentane emulsion as a stroke and ischemia therapy
    Patent number: 11571467
    Abstract: The present invention provides methods and combinations for reducing the infarct volume in a tissue of a subject undergoing ischemia or at risk of developing ischemia.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 7, 2023
    Assignee: BioVentures, LLC
    Inventors: William Culp, Robert Skinner, Evan C. Unger
  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 11534492
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: February 7, 2021
    Date of Patent: December 27, 2022
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • COMPOSITIONS OF FLUOROCARBON NANOEMULSION, AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20220401364
    Abstract: The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.
    Type: Application
    Filed: April 15, 2022
    Publication date: December 22, 2022
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES
    Publication number: 20220305143
    Abstract: The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 29, 2022
    Inventors: Evan C. Unger, Emmanuelle Joelle Meuillet, Iman Daryaei, Maria Fernanda Acosta
  • Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
    Patent number: 11304899
    Abstract: The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: April 19, 2022
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • Phospholipid composition and microbubbles and emulsions formed using same
    Patent number: 11160885
    Abstract: A composition, and method thereof, for stabilizing a fluorocarbon emulsion includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid.
    Type: Grant
    Filed: January 26, 2019
    Date of Patent: November 2, 2021
    Assignee: Microvascular Therapeutics LLC
    Inventors: Evan C. Unger, Daniel C. Evans
  • COMPOSITIONS AND METHODS FOR TARGETED CONTRAST AGENTS FOR MOLECULAR IMAGING
    Publication number: 20210321985
    Abstract: The invention provides novel targeted particles as contrast agents for use in molecular imaging of vulnerable plaque, and methods of preparation and application thereof.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 21, 2021
    Inventors: Terry Matsunaga, Craig C. Weinkauf, Evan C. Unger, Edmund R. Marinelli
  • FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
    Publication number: 20210260190
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Application
    Filed: February 7, 2021
    Publication date: August 26, 2021
    Inventor: Evan C. Unger
  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 10946097
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: August 24, 2019
    Date of Patent: March 16, 2021
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • ADJUSTING PARTICLE SIZE IN FLUOROCARBON NANOEMULSIONS
    Publication number: 20210023021
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Application
    Filed: September 16, 2020
    Publication date: January 28, 2021
    Inventors: Evan C. Unger, Edmund Marinelli
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING ALZHEIMER'S DISEASE
    Publication number: 20210008204
    Abstract: The invention provides microbubbles and/or nanodroplets labeled with diagnostic and/or therapeutic ligands that are useful in the detection and treatment of Alzheimer's disease, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 14, 2021
    Inventors: Evan C. Unger, Iman Daryaei, Emmanuelle Joelle Meuillet
  • Adjusting particle size in fluorocarbon nanoemulsions
    Patent number: 10780060
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: September 22, 2020
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund Marinelli
  • NANOCOMPOSITES FOR IMAGING AND DRUG DELIVERY
    Publication number: 20200172908
    Abstract: The invention provides a composition which includes a shell comprising at least one lipid, wherein said shell defines an enclosed space, a gas disposed within the enclosed space, and a coating of a polyalkylene glycol attached to and extending outwardly from lipid shell, wherein the lipid shell has a diameter from about 30 nanometers to about 5 microns.
    Type: Application
    Filed: January 6, 2020
    Publication date: June 4, 2020
    Inventors: Evan C. Unger, Edmund Marinelli, Delphine El Mehdi, Paul K. Olson
  • Buffered Oxygen Therapeutic
    Publication number: 20200163903
    Abstract: An oxygen therapeutic composition, which includes a perfluorocarbon material having a boiling point of about 4 degrees Celsius to about 60 degrees Celsius, a lipid; a viscosity modifier; a buffer.
    Type: Application
    Filed: December 7, 2018
    Publication date: May 28, 2020
    Inventors: Evan C. Unger, Edmund R. Marinelli