Patents by Inventor Evan C. Unger

Evan C. Unger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 10946097
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: August 24, 2019
    Date of Patent: March 16, 2021
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • ADJUSTING PARTICLE SIZE IN FLUOROCARBON NANOEMULSIONS
    Publication number: 20210023021
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Application
    Filed: September 16, 2020
    Publication date: January 28, 2021
    Inventors: Evan C. Unger, Edmund Marinelli
  • COMPOSITIONS AND METHODS OF DETECTING AND TREATING ALZHEIMER'S DISEASE
    Publication number: 20210008204
    Abstract: The invention provides microbubbles and/or nanodroplets labeled with diagnostic and/or therapeutic ligands that are useful in the detection and treatment of Alzheimer's disease, or related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 14, 2021
    Inventors: Evan C. Unger, Iman Daryaei, Emmanuelle Joelle Meuillet
  • Adjusting particle size in fluorocarbon nanoemulsions
    Patent number: 10780060
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: September 22, 2020
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund Marinelli
  • NANOCOMPOSITES FOR IMAGING AND DRUG DELIVERY
    Publication number: 20200172908
    Abstract: The invention provides a composition which includes a shell comprising at least one lipid, wherein said shell defines an enclosed space, a gas disposed within the enclosed space, and a coating of a polyalkylene glycol attached to and extending outwardly from lipid shell, wherein the lipid shell has a diameter from about 30 nanometers to about 5 microns.
    Type: Application
    Filed: January 6, 2020
    Publication date: June 4, 2020
    Inventors: Evan C. Unger, Edmund Marinelli, Delphine El Mehdi, Paul K. Olson
  • Buffered Oxygen Therapeutic
    Publication number: 20200163903
    Abstract: An oxygen therapeutic composition, which includes a perfluorocarbon material having a boiling point of about 4 degrees Celsius to about 60 degrees Celsius, a lipid; a viscosity modifier; a buffer.
    Type: Application
    Filed: December 7, 2018
    Publication date: May 28, 2020
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC
    Publication number: 20200054750
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Application
    Filed: August 24, 2019
    Publication date: February 20, 2020
    Inventor: Evan C. Unger
  • ISO-OSMOTIC AND NEAR ISO-OSMOTIC OXYGEN THERAPEUTIC FORMULATIONS AND METHODS THEREOF
    Publication number: 20190365665
    Abstract: The invention provides novel iso-osmotic or near iso-osmotic formulations of fluorocarbon emulsions that are useful as oxygen therapeutics, for example, for treating sickle cell disease and related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: January 24, 2018
    Publication date: December 5, 2019
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • Phospholipid composition and microbubbles and emulsions formed using same
    Patent number: 10493173
    Abstract: A composition, and method thereof, for stabilizing a fluorocarbon emulsion includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: December 3, 2019
    Assignee: Microvascular Therapeutics LLC
    Inventors: Evan C. Unger, Daniel C. Evans
  • Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
    Patent number: 10456468
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 29, 2019
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • Microbubble Compositions, Method of Making Same, and Method Using Same
    Publication number: 20190247526
    Abstract: A method of forming a plurality of microbubbles, wherein the method disposes in a sealed container comprising a first volume at ambient pressure, a second volume of a mixture comprising one or more microbubble stabilizing materials. The first volume is greater than said second volume. The method further comprises sealing said container, introducing a gas into said sealed container, and shaking the container to form said plurality of microbubbles.
    Type: Application
    Filed: March 6, 2019
    Publication date: August 15, 2019
    Inventors: Evan C. Unger, Patrick W. Hendon
  • PHOSPHOLIPID COMPOSITION AND MICROBUBBLES AND EMULSIONS FORMED USING SAME
    Publication number: 20190184038
    Abstract: A composition, and method thereof, for stabilizing a fluorocarbon emulsion includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid.
    Type: Application
    Filed: January 26, 2019
    Publication date: June 20, 2019
    Inventors: Evan C. Unger, Daniel C. Evans
  • Microbubble compositions, method of making same, and method using same
    Patent number: 10279053
    Abstract: A method of forming a plurality of microbubbles, wherein the method disposes in a sealed container comprising a first volume at ambient pressure, a second volume of a mixture comprising one or more microbubble stabilizing materials. The first volume is greater than said second volume. The method further comprises sealing said container, introducing a gas into said sealed container, and shaking the container to form said plurality of microbubbles.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: May 7, 2019
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Patrick W. Hendon
  • COMPOSITIONS AND METHODS FOR TARGETED CONTRAST AGENTS FOR MOLECULAR IMAGING
    Publication number: 20190125307
    Abstract: The invention provides novel targeted particles as contrast agents for use in molecular imaging of vulnerable plaque, and methods of preparation and application thereof.
    Type: Application
    Filed: April 29, 2017
    Publication date: May 2, 2019
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • SYSTEMS AND METHODS FOR FILLING VIALS WITH GASES
    Publication number: 20190117800
    Abstract: The invention provides novel apparatus and methods for efficiently and accurately filling vials with gaseous materials such as a fluorinated gas, with or without concomitantly filling the vials with another liquid or solid material.
    Type: Application
    Filed: April 19, 2017
    Publication date: April 25, 2019
    Inventors: Evan C. Unger, Daniel C. Evans, Varadarajan Ramaswami
  • Buffered oxygen therapeutics
    Patent number: 10166200
    Abstract: An oxygen therapeutic composition, which includes a perfluorocarbon material having a boiling point of about 4 degrees Celsius to about 60 degrees Celsius, a lipid; a viscosity modifier; a buffer.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: January 1, 2019
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • COMPOSITIONS OF FLUOROCARBON NANOEMULSION, AND METHODS OF PREPARATION AND USE THEREOF
    Publication number: 20180360754
    Abstract: The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.
    Type: Application
    Filed: December 20, 2016
    Publication date: December 20, 2018
    Inventors: Evan C. Unger, Edmund R. Marinelli
  • ADJUSTING PARTICLE SIZE IN FLUOROCARBON NANOEMULSIONS
    Publication number: 20180221302
    Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).
    Type: Application
    Filed: August 15, 2016
    Publication date: August 9, 2018
    Inventors: Evan C. Unger, Edmund Marinelli
  • TREATMENT OF ACUTE COMPLICATIONS OF SICKLE CELL DISEASE
    Publication number: 20180153824
    Abstract: The invention provides pharmaceutical compositions and dosage forms of fluorocarbon nanoemulsions that are useful for treating sickle cell disease and related diseases and conditions, as well as methods of preparation and use thereof.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 7, 2018
    Inventors: Evan C. Unger, Solomon F. Ofori-Acquah, David B. Wilson
  • PHOSPHOLIPID COMPOSITION AND MICROBUBBLES AND EMULSIONS FORMED USING SAME
    Publication number: 20180092995
    Abstract: A composition, and method thereof, for stabilizing a fluorocarbon emulsion includes phosphatidylcholine, phosphatidylethanolamine-PEG, and a cone-shaped lipid.
    Type: Application
    Filed: August 17, 2017
    Publication date: April 5, 2018
    Inventors: Evan C. Unger, Daniel C. Evans