Patents by Inventor Ezio Bombardelli

Ezio Bombardelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMULATIONS FOR THE TREATMENT AND PREVENTION OF OBESITY
    Publication number: 20150258157
    Abstract: Disclosed are compositions containing: a) Phaseolus vulgaris extract; b) Cynara scolymus extract; c) Echinacea angustifolia extract; d) Vitis vinifera extract and optionally e) Panax ginseng extract, mixed with suitable excipients.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 17, 2015
    Inventors: Ezio Bombardelli, Fabrizio Corti
  • Novel Extracts of Cynara Scolymus, Coffea ssp. And Olea Europaea For The Treatment Of Metabolic Syndrome
    Publication number: 20150231193
    Abstract: Disclosed is a composition comprising: a. Cynara extract having a caffeoylquinic acid content ranging from 30 to 45% by weight, a flavonoid content ranging from 8 to 16% by weight and a cynaropicrin content ranging from 10 to 18% by weight; b. Coffea spp. extract containing between 40% and 80% by weight of caffeoylquinic acids; c. Olea europaea extract containing between 30% and 40% polyphenols, with a verbascoside content exceeding 5% and a hydroxytyrosol content exceeding 1.5%.
    Type: Application
    Filed: September 19, 2013
    Publication date: August 20, 2015
    Inventors: Ezio Bombardelli, Fabrizio Corti
  • Compositions for the treatment of disorders of the upper respiratory tract and influenza syndromes
    Patent number: 9101604
    Abstract: The present invention relates to compositions based on benzophenanthridine alkaloids, extract of Hippophae rhamnoides and extract of Echinacea angustifolia which possess antibacterial, antiviral and anti-inflammatory activity, and are useful in the treatment of bacterial and viral infections of the upper respiratory tract, and in the treatment of influenza.
    Type: Grant
    Filed: May 25, 2009
    Date of Patent: August 11, 2015
    Assignee: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • COMPOSITIONS FOR TREATMENT OF CANCER-RELATED FATIGUE
    Publication number: 20150202246
    Abstract: Disclosed are compositions containing extracts of (a) Panax ginseng C. A. Mayer, (b) Zingiber officinale, (c) Echinacea angustifolia and (d) Silybum marianum or the phospholipid complex of silybin with phospholipids as active ingredients, mixed with suitable excipients.
    Type: Application
    Filed: July 11, 2013
    Publication date: July 23, 2015
    Inventors: Ezio Bombardelli, Fabrizio Corti
  • Formulations for the treatment of mucositis induced by antitumor or immunosuppressive therapy
    Patent number: 8940338
    Abstract: Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of mucositis.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: January 27, 2015
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana
  • SALIX EXTRACT, ITS USE AND FORMULATIONS CONTAINING IT
    Publication number: 20140378405
    Abstract: The present invention relates to an extract of Salix spp obtainable by fractioning on a resin and to the process for its preparation. The extract of the invention is characterized by an high content in salicin derivatives, reduced content in high molecular tannins and a content in proanthocyanidins sufficient to inhibit some tissue metal proteases. The product is formulated in oils rich in ?-3 and ?-6 acids which provide a better absorption of the extract active principles, also increasing synergetically their action.
    Type: Application
    Filed: June 24, 2013
    Publication date: December 25, 2014
    Inventors: Ezio BOMBARDELLI, Andrea GIORI, Alessandro ANELLI
  • Compositions comprising lipophilic extracts of and for the prevention and treatment of gastro-oesophageal reflux and chemotherapy-induced emesis
    Patent number: 8859019
    Abstract: The present invention relates to compositions consisting of a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia, obtained by extraction with carbon dioxide under supercritical conditions, which are useful for the prevention and treatment of oesophageal reflux and chemotherapy-induced emesis.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 14, 2014
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • CYNARA SCOLYMUS EXTRACTS FOR THE TREATMENT OF DYSLIPIDAEMIA
    Publication number: 20140228428
    Abstract: The present invention relates to the preparation of Cynara scolymus leaf extracts, which are useful for the prevention and treatment of dyslipidaemia, in particular to increase HDL cholesterol in patients at cardiovascular risk. Said extracts are useful to normalise the lipid and carbohydrate balances and significantly increase the value of HDL cholesterol by favourably changing the LDL/HDL ratio, especially in post-infarction patients with drug-induced dyslipidaemia.
    Type: Application
    Filed: September 13, 2012
    Publication date: August 14, 2014
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • COMPOSITIONS FOR THE TREATMENT OF PERIPHERAL ULCERS OF VARIOUS ORIGINS
    Publication number: 20140220165
    Abstract: The present invention relates to combinations of an agent that stimulates cell proliferation and an anti-inflammatory/analgesic, which are useful in the treatment of peripheral ulcers of various origins, such as radiation dermatitis, diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores, and the associated skin infections, proctitis, vulvovaginitis and haemorrhoids with vascular lesions. These combinations can be presented as formulations for topical use.
    Type: Application
    Filed: September 13, 2012
    Publication date: August 7, 2014
    Applicant: INDENA S.P.A.
    Inventor: Ezio Bombardelli
  • FORMULATIONS FOR THE TREATMENT OF DISORDERS OF THE UPPER RESPIRATORY TRACT
    Publication number: 20130280355
    Abstract: The present invention relates to formulations containing extracts of Vaccinium myrtillus or other species rich in anthocyanosides, Punica granatum, Echinacea, and optionally Krameria triandra. Said formulations are useful in the treatment of disorders of the mouth and its adnexa, the throat and respiratory tract, and in the treatment of influenza.
    Type: Application
    Filed: October 5, 2011
    Publication date: October 24, 2013
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Massimo Ronchi, Paolo Morazzoni
  • FORMULATIONS CONTAINING EXTRACTS OF ECHINACEA ANGUSTIFOLIA AND ZINGIBER OFFICINALE WHICH ARE USEFUL IN REDUCING INFLAMMATION AND PERIPHERAL PAIN
    Publication number: 20130266672
    Abstract: Disclosed is a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia for the treatment of itching, peripheral pain, superficial and deep inflammatory and painful states, pain associated with muscle spasms, herpes pain, and radiodermatitis caused by oncological radiotherapy, with or without fungal or bacterial infections.
    Type: Application
    Filed: July 20, 2011
    Publication date: October 10, 2013
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni
  • COMPOSITIONS FOR THE TREATMENT OF PERIPHERAL ULCERS OF VARIOUS ORIGINS
    Publication number: 20130236575
    Abstract: The present invention relates to compositions containing a combination of a cell proliferation-stimulating agent with vasokinetic properties and an antimicrobial, antifungal and antiviral agent with an anti-inflammatory/analgesic, which is useful in the treatment of peripheral ulcers of various origins, such as diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores and the associated skin infections. Said combination could be presented as formulations for topical or systemic use.
    Type: Application
    Filed: October 21, 2011
    Publication date: September 12, 2013
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Massimo Ronchi
  • Compositions for the treatment and prevention of infections of the oral cavity
    Patent number: 8496975
    Abstract: The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: July 30, 2013
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • Compositions comprising lipophilic extracts of and for the prevention and treatment of gastro-oesophageal reflux and chemotherapy-induced emesis
    Patent number: 8361521
    Abstract: The present invention relates to compositions consisting of a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia, obtained by extraction with carbon dioxide under supercritical conditions, which are useful for the prevention and treatment of oesophageal reflux and chemotherapy-induced emesis.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 29, 2013
    Assignee: Indena, S.p.A.
    Inventor: Ezio Bombardelli
  • Formulations for the treatment of arthritis conditions
    Patent number: 8343554
    Abstract: The present invention relates to formulations comprising combinations of analgesic/anti-inflammatory, immunomodulating and cartilage-reconstructing agents in particular comprising saligenig, boswellic acid, procyanidins, N-acety-glucosamine and either glucoronic acid or glucoronolactone, for the treatment of rheumatoid arthritis and, more generally, of arthritis conditions.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: January 1, 2013
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli
  • Antitumoral agents with a benzophenanthridine structure and formulations containing them
    Patent number: 8337903
    Abstract: The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.
    Type: Grant
    Filed: February 16, 2009
    Date of Patent: December 25, 2012
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva
  • COMPOSITIONS COMPRISING ANDROGRAPHIS PANICULATA EXTRACTS COMBINED WITH GINKGO BILOBA EXTRACTS COMPLEXED WITH PHOSPHOLIPIDS, AND THEIR USE
    Publication number: 20120301560
    Abstract: The present invention relates to compositions comprising Andrographis paniculata extracts combined with Ginkgo biloba extracts complexed with phospholipids. Moreover, the compositions administered in oils rich in ?-3 polyunsaturated fatty acids demonstrate a further synergic effect between the ingredients. Said compositions are useful in the treatment of neurodegenerative disorders, in particular Alzheimer's disease and multiple sclerosis.
    Type: Application
    Filed: January 3, 2011
    Publication date: November 29, 2012
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Andrea Giori
  • Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel
    Patent number: 8318957
    Abstract: A process for the preparation of 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) said process comprising: reacting 10-deacetylbaccatin III with a trichloroacetic acid activated derivative to obtain a reaction mixture, and performing an isolation step on said reaction mixture obtain purified 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) having a content, of corresponding 7- or 10 mono-trichloroacetyl derivatives lower than 0.1% as determined by HPLC.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: November 27, 2012
    Assignee: Indena S.p.A.
    Inventors: Bruno Gabetta, Andrea Gambini, Ezio Bombardelli, Gabriele Fontana
  • SALIX EXTRACT, ITS USE AND FORMULATIONS CONTAINING IT
    Publication number: 20120270825
    Abstract: The present invention relates to an extract of Salix spp obtainable by fractioning on a resin and to the process for its preparation. The extract of the invention is characterized by an high content in salicin derivatives, reduced content in high molecular tannins and a content in proanthocyanidins sufficient to inhibit some tissue metal proteases. The product is formulated in oils rich in ?-3 and ?-6 acids which provide a better absorption of the extract active principles, also increasing synergetically their action.
    Type: Application
    Filed: July 2, 2012
    Publication date: October 25, 2012
    Inventors: Ezio Bombardelli, Andrea Giori, Alessandro Anelli
  • FORMULATIONS WITH SANGUINARINE, CHELERYTHRINE OR CHELIDONINE FOR THE TREATMENT OF WARTS, VERRUCAS AND PSORIATIC PLAQUES
    Publication number: 20120263810
    Abstract: The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.
    Type: Application
    Filed: June 22, 2012
    Publication date: October 18, 2012
    Applicant: INDENA S.P.A
    Inventors: Ezio Bombardelli, Gabriele Fontana, Paolo Morazzoni, Antonella Riva, Massimo Ronchi