Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.

Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitizing the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.

Abstract: The invention provides formulations containing sanguinarine, chelerythrine or chelidonine or their salts or extracts containing them, mixed with suitable vehicles and/or excipients, for the treatment of common skin warts and verrucas, anal and vulvar warts and psoriatic plaques.

Abstract: The use of benzophenanthridine alkaloids and the salts thereof for the preparation of medicaments for the treatment of tumors is disclosed.

Abstract: Compositions including Serenoa repens, Echinacea and Hypericum perforatum extracts and selenium compounds for the treatment of prostate disorders, in particular for the treatment of prostate cancer, prostatitis, prostatosis and urinary incontinence.

Abstract: Methods for treating and preventing mucositis, in particular mucositis following the administration of chemotherapy drugs or a combination of said drugs with radiotherapy, are disclosed herein. More specifically, disclosed herein is the administration of a therapeutically effective amount of at least one of an anthocyanoside, a proanthocyanidin, or an extract containing at least one of an anthocyanoside or a proanthocyanidin for the treatment or prevention of mucositis. The therapeutically effective amount of the anthocyanoside, proanthocyanidin or extract can be administered alone or in combination with a therapeutically effective amount of at least one of an anti-inflammatory agent, immunomodulating agent, analgesic, antimicrobial agent or antifungal agent. Also disclosed herein are pharmaceutical compositions for treating and preventing mucositis.

Abstract: Formulations containing sanguinarine or chelerythrine or the salts thereof or extracts containing them in admixture with suitable carriers and/or excipients for the treatment and/or prevention of mucositis.

Abstract: The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine from Ferula spp extracts.

Abstract: Compositions comprising: vasokinetic natural coumarins or extracts containing them; anti-phosphodiesterase agents selected from 3,7-O-di-(2-hydroxyethyl)icaritin or 7-O-hydroxyethyl-icariside II and/or forskolin or extracts containing them; phytoestrogens selected from ferutinine or ferutinine-containing extracts of Ferula sp. or p-pivaloylferutinine.

Abstract: Combinations of vasoprotective agents useful for the prevention and the treatment of vascular injuries induced by an excess of plasma lipids comprising polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.

Abstract: A Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing the Cynara scolymus extract with a Phaseolus vulgaris extract. The composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.

Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.

Abstract: The present invention relates to oral pharmaceutical and cosmetic compositions for the treatment of cellulite containing Vitis vinifera extracts, Centella asiatica triterpenes and dimeric Ginkgo biloba flavonoids, in the free form or complexed with phospholipids.

Abstract: Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C1-C8 alkyl residue, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; the G1 and G2 junctions, which can be the same or different, are —CO—, —CONH—, —CR2— groups in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker-G2 group is the —CO— group. The compounds of formula I have antiproliferative, antinflammatory, antiarthritic and antiviral activity.

Abstract: The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.

Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.

Abstract: Compositions comprising: saligenin or derivatives thereof or Salix ssp extracts containing from 10 to 50% of saligenin; substantially pure andrographolide or andrographolide enriched Andrographis paniculata extract containing from 5 to 30% of andrographolide; optionally N-acetyl-glucosamine and/or glucuronic acid or glucuronolactone.

Abstract: Novel camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.

Abstract: The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in ?-3 and ?-6 acids which enhance the vascular activity.

Abstract: This invention relates to combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication. The active compounds are selected from a:—esculoside or visnadine;—forskolin or extracts containing it, or alternatively, purified lipophilic extracts of plants of the genus Ipomea;—esters of ximenynic acid;—optionally, at least one compound selected from a icarin or derivatives or extracts thereof which contain it, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.