Abstract: A method of identifying and characterizing novel Cas protein and guide RNAs with desired activity and specificity. The disclosure further comprises compositions and systems comprising engineered Cas protein and guide RNAs with desired activity and specificity.

Abstract: A big data processing method based on direct computation of compressed data. The method includes 1) compressing, based on a modified Sequitur compression method, original input data according to a smallest compression granularity given by an user, and transforming them into a directed acyclic graph, DAG, consisting of digits; and 2) determining an optimal traversal pattern, and performing a top-downward traversal or a bottom-upward traversal on the DAG in the step 1) based on the determined optimal traversal pattern so as to enable direct processing of the compressed data. By providing a modified Sequitur algorithm and top-downward and bottom-upward traversal strategies in the disclosure, direct processing of compressed data is enabled, significant improvement in time and space has been gained with broad applicability, and certain representations with respect to more advanced document analytics can still be derived on the basis of these.

Abstract: A heat exchanger includes: a header, having a first end and a second end which are opposite each other, and further having an inner cavity; a plurality of heat exchange tubes arranged in an axial direction of the header, with ends of the plurality of heat exchange tubes being connected to the header; and a connecting tube, the connecting tube having a connecting part and a supply part which is connected to the connecting part and also connected to the first end of the header, the supply part being configured such that a flow direction of a heat exchange medium supplied to a predetermined number of heat exchange tubes through the inner cavity of the header is not parallel to an axis of the header, the predetermined number of heat exchange tubes being a predetermined number of heat exchange tubes counted from the first end of the header. By using the heat exchanger according to the embodiments of the present disclosure, heat exchanger performance can be improved.

Abstract: An R-tree index merging and updating method and apparatus based on a Hilbert curve, and a medium. The method comprises: S1, acquiring a first R-tree to be merged and a second R-tree into which the first R-tree is to be inserted; S2, querying a node for insertion, for each merged leaf node in a leaf node level of the first R-tree by means of a “top to bottom” hierarchical query algorithm; S3, inserting, according to an order of the Hilbert values, spatial objects included in each leaf node in the first R-tree into the node for insertion that is determined in S2, thereby merging the two R-trees; and S4, for the second R-tree after merging, updating information stored in each node level by level according to an order from a leaf node to a root node.

Abstract: Provided are a spin orbit torque magnetic random access memory cell, a spin orbit torque magnetic random access memory array and a method for calculating a Hamming distance, wherein the spin orbit torque magnetic random access memory cell includes a magnetic tunnel junction; a first transistor, a drain terminal of the first transistor being connected to a bottom of the magnetic tunnel junction; and a second transistor, a drain terminal of the second transistor being connected to a top of the magnetic tunnel junction.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

Abstract: A system and method for computing a metric indicating a user operation of an application is described. The system accesses online activity data of a user operation of the application. The system filters the online activity data based on a preset time range. An after-hours activity score is calculated based on a type of activity or a duration of an activity from the filtered online activity data, and a weight assigned to the type of activity or the duration of the activity. The system computes an after-hours metric based on the after-hours activity score. A configuration setting for the application based on the after-hours metric is applied to the application.

Abstract: A piezoelectric device includes: a base having at least one hole, a heat conductive portion disposed in the at least one hole and in contact with a wall of the at least one hole, and at least one piezoelectric sensor disposed on the base. A thermal conductivity of the heat conductive portion is greater than a thermal conductivity of the base. Each piezoelectric sensor includes: a first electrode, a piezoelectric pattern made of a piezoelectric material and a second electrode that are sequentially stacked in a thickness direction of the base.

Abstract: A transducer, a method of manufacturing a transducer, and a transducing device are provided. The transducer includes a receiving unit and a transmitting unit. The receiving unit includes a first receiving electrode, a first piezoelectric film, and a second receiving electrode which are sequentially stacked, and the receiving unit is configured to convert a first acoustic wave signal into an electrical signal by using a piezoelectric effect of the first piezoelectric film. The transmitting unit is configured to receive a control signal, which is based on the electrical signal, to transmit a second acoustic wave signal.

Abstract: The present disclosure relates to systems and methods for a handover. The methods may include establishing a connection between a vehicle terminal and a first macro evolved Node B (MeNB) and a connection between the vehicle terminal and a secondary evolved Node B (SeNB), the vehicle terminal in a dual connectivity mode with the first MeNB and the SeNB; receiving, by the vehicle terminal, a handover command from the first MeNB; and disconnecting, based on the handover command, the vehicle terminal from the first MeNB and establishing synchronization between the vehicle terminal and a second MeNB, wherein the connection between the vehicle terminal and the SeNB is maintained. The SeNB is a secondary vehicle terminal meeting a preset condition or an SeNB installed at a fixed location.

Abstract: A management and distribution device for insect breeding includes a main body, an upper cover, and a lower cover. The upper cover is clamped to a top portion of the main body, and the lower cover is clamped to a lower end of the main body. Three partition plates for insects to climb are clamped in an inner portion of the main body, and the three partition plates are wave-shaped. A notch is defined at a lower middle portion of each of the three partition plates, a plurality of through holes for insect faeces to pass through are defined on a bottom of the main body, an insertion opening is defined at a lower end of an outer wall of the main body, and a hinge door is rotatably disposed at the lower end of the outer wall of the main body.

Abstract: A distribution network system and method. The distribution system has a plurality of communication channels and is connected to a mesh network. The mesh network uses one of the plurality of communication channels as a distributable network channel. The distribution network system includes an already-distributed network node and a to-be-distributed network node. The already-distributed network node is located in the mesh network and is configured to broadcast a mesh network beacon to the distributable network channel. The to-be-distributed node is configured to alternately monitor whether the mesh network beacon is detected on each communication channel.

Abstract: Provided are a display substrate, a method for manufacturing a display substrate and a display apparatus. The display substrate includes a base, a drive structure layer disposed on the base, a light emitting element disposed on the drive structure layer, an encapsulation layer disposed on the light emitting element, a circular polarizer layer disposed on the encapsulation layer, and a lens definition layer and a lens structure layer disposed on the circular polarizer layer. The light emitting element includes a pixel definition layer provided with a plurality of sub-pixel openings; the lens structure layer includes a plurality of lenses disposed at intervals, the lens definition layer is disposed in a gap region between adjacent lenses, and an orthographic projection of each lens on the base contains an orthographic projection of a sub-pixel opening on the base.

Abstract: Provided herein are nucleic acid molecules that target the BCL11A enhancer functional regions, compositions comprising the nucleic acid molecules and methods for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels. In particular, the nucleic acid molecules target the +62, +58, and/or the +55 enhancer functional regions.

Abstract: A micro total analysis system, operating method and manufacturing method thereof are provided. The micro total analysis system includes at least one micro total analysis unit each including: microfluidic device including first electrode and dielectric layer connected to each other, where the dielectric layer drives to-be-measured droplet to move based on voltage of the first electrode; and acoustic wave detection device including second electrode connected to the dielectric layer, where the dielectric layer is also used as transducer of the acoustic wave detection device, and configured to generate acoustic wave toward the droplet based on voltage of the second electrode, and generate a detection result corresponding to the droplet based on received acoustic wave. The micro total analysis system, the operating method and the manufacturing method thereof enables the microfluidic device and the acoustic wave detection device to be integrated in the same chip.

Abstract: Disclosed are a display apparatus, a drive chip, and an electronic device. When determining that a disconnected signal line exists, a drive chip sends a control signal to a signal line repair module, so that a shift output end of a first shift unit corresponding to the disconnected signal line outputs an enable signal, so as to control a corresponding connection switch in a connection switch group to be turned on, to enable the disconnected signal line to be electrically connected to a repair line. The display apparatus may repair a disconnected signal line without being returned to a factory and a manual operation.

Abstract: Techniques for hierarchical encryption for data storage are disclosed, in one or more embodiments. These techniques include parsing an electronic database storage request, based on the syntax of the request, to identify a plurality of request elements and determining, using one or more trained machine learning (ML) models, one or more sensitivities associated with the plurality of request elements. The techniques further include identifying one or more encryption techniques for the plurality of request elements based on the one or more sensitivities, encrypting data associated with the database storage request using the identified one or more encryption techniques, and storing the encrypted data and one or more associated encryption keys in an electronic database, using the electronic database storage request.

Abstract: A driving backplane, a transfer method for a light-emitting diode chip (21), and a display apparatus. The driving backplane comprises: a base substrate (10), a driving circuit, a plurality of electromagnetic structures (13), and a plurality of contact electrodes (12). The plurality of electromagnetic structures (13) in the driving backplane are symmetrically arranged relative to a first straight line (L1) and a second straight line (L2). A current signal can be applied to each electromagnetic structure (13) by means of the driving circuit. Stress generated by a transfer carrier plate (20) according to the magnetic force of each electromagnetic structure (13) moves the transfer carrier plate (20). When the transfer carrier plate (20) is stress balanced in each direction parallel to the surface of the transfer carrier plate (20), the light-emitting diode chip (21) is precisely aligned to corresponding contact electrodes (12).