Abstract: A BIER domain includes a host and a routing device that has a neighbor relationship with the host. The host duplicates a packet and forwards the packet to another host via the routing device. After receiving the packet including a BIER option, the routing device pops up, from the packet, an IPV6 extension header including the BIER option, and then sends the packet to the host. This avoids a case in which the packet received by the host includes the IPV6 extension header including the BIER option, thereby reducing a difficulty of processing the packet by the host and reducing overheads of processing the packet by the host.

Abstract: Transcriptomes of individual neurons provide rich information about cell types and dynamic states. However, it is difficult to capture rare dynamic processes, such as adult neurogenesis, because isolation from dense adult tissue is challenging, and markers for each phase are limited. Here, Applicants developed Nuc-seq, Div-Seq, and Dronc-Seq. Div-seq combines Nuc-Seq, a scalable single nucleus RNA-Seq method, with EdU-mediated labeling of proliferating cells. Nuc-Seq can sensitively identify closely related cell types within the adult hippocampus. Div-Seq can track transcriptional dynamics of newborn neurons in an adult neurogenic region in the hippocampus. Dronc-Seq uses a microfluidic device to co-encapsulate individual nuclei in reverse emulsion aqueous droplets in an oil medium together with one uniquely barcoded mRNA-capture bead. Finally, Applicants found rare adult newborn GABAergic neurons in the spinal cord, a non-canonical neurogenic region.

Abstract: The present disclosure relates to identifying novel tumor immune evasion targets. A CRISPR activation screen was employed to identify novel checkpoint inhibitor targets, where upon upregulation, conferred tumor resistance to cytotoxic T cells in model cancer cell lines. Using MAGeCK and FDR analyses to identify candidate genes that were enriched in cancer cells, B3GNT2, MCL1, BCL2A1 and JUNB were identified as the most enriched after a pathway analysis of the top 576 genes prioritized by MAGeCK. Currently, these four genes have not been identified or suggested as possible checkpoint inhibitor targets. Provided herein are methods of targeting the expression or activity of B3GNT2, MCL1, BCL2A1 and JUNB using small molecule agents and/or gene editing methods with the aim of enhancing anti-tumor immunity in subjects in need thereof.

Abstract: The invention provides a micro-interface enhanced oxidation system and an oxidation method for preparing hydrogen peroxide, wherein the micro-interface enhanced oxidation system includes: an oxidation reactor, wherein a top portion of a side surface is provided with a liquid phase pipeline for delivering hydrogenated anthraquinone, and a bottom portion of the side surface is provided with a gas phase pipeline for delivering air; and a liquid distributor, a packing section, a seal pan and a hybrid micro-interface unit that are arranged in order from top to bottom are arranged in the oxidation reactor, wherein the hybrid micro-interface unit comprises a upper-mounted micro-interface generator and a lower-mounted micro-interface generator that are communicated with each other up and down, and the hydrogenated anthraquinone delivered in goes down in turn until being mixed with the air in the hybrid micro-interfacial unit to be dispersed and crushed after being distributed through the liquid distributor.

Abstract: A wheel-side reducer system includes a housing, a speed reduction assembly, and a steering knuckle. The housing includes a front housing and a rear housing. The front housing and the rear housing are arranged opposite to each other and define an accommodating space together. The speed reduction assembly is arranged in the accommodating space. The steering knuckle is integrally molded on the front housing. The integrally molding of the steering knuckle on the front housing not only simplifies the production process of the housing, but also makes a connection between the steering knuckle and the front housing more reliable. Meanwhile, the integration level of the wheel-side reducer system can also be improved, to reduce the size of the wheel-side reducer system. A vehicle with the wheel-side reducer system is further disclosed.

Abstract: The disclosure provides a connector and an electronic device using the connector. The connector is connected with a conductive element. The connector includes a terminal support component, a multiple of gold fingers and an electric conversion component. The terminal support component includes a first surface and a second surface. The first surface is opposite to the second surface or the first surface and the second surface are arranged at intervals. The multiple of gold fingers symmetrically arranged on the first surface and the second surface. The electric conversion component includes a main electric unit and two auxiliary conductive units. The main electric unit is electrically connected the two auxiliary conductive units and the conductive element. The two auxiliary conductive units are electrically connected with the gold fingers that respectively arranged on the first surface and the second surface of the terminal support component.

Abstract: Methods, apparatus and systems for counting and recognizing objects or people based on rhythmic motion monitoring are described. A described method comprises: obtaining N1 time series of channel information (TSCI) of a wireless multipath channel that is impacted by a rhythmic motion of an object in a venue, wherein the N1 TSCI is extracted from a wireless signal transmitted from a transmitter to a receiver through the wireless multipath channel; decomposing each of the N1 TSCI into N2 time series of channel information components (TSCIC), wherein a channel information component (CIC) of each of the N2 TSCIC at a time comprises a respective component of a channel information (CI) of the TSCI at the time, wherein N1 and N2 are positive integers; monitoring the rhythmic motion of the object based on at least one of: the N1*N2 TSCIC and the N1 TSCI.

Abstract: A sunroof assembly includes a panel supporting part to support a movable panel in a vehicle width direction; a slider supported on a guide rail; and a link. One end of the link is rotatably connected to the panel supporting part, and the other end has a first guided part. The first guided part movable in a first guide groove of the slider. The link includes a first rotating shaft part between one end and the other end, which is supported on the guide rail in a way that is movable in the front-rear direction of the vehicle. The link rotating around the first rotating shaft part when the link rotates around the first rotating shaft part, and an end of the panel supporting part connected to the link is displaced in an up-down direction of the vehicle.

Abstract: The present disclosure provides a guide block that can be universal to the left and right guide rails of a sunroof device, thereby reducing manufacturing cost and component types. The guide block for guiding a sunroof panel comprises a pair of left and right guide channels, wherein a sliding surface of at least one of the left and right guide channels is connected to a sliding surface of a guide rail of the sunroof panel at one end thereof in a front-rear direction of a vehicle, and a guided part of the sunroof panel enters the guide block from the sliding surface of the guide rail and slides on the sliding surface of the at least one; and a guide rail locking part arranged on one end of the guide block to fix the guide block to the guide rail.

Abstract: An acoustic device comprises a shell and a sound producing assembly, the shell being provided with an installation hole and a sound outlet, and the sound producing assembly being fixed inside the shell. The sound producing assembly has a diaphragm separating a cavity of the acoustic device into a front cavity and a back cavity, a first part of the shell corresponding to the front cavity and/or a second part of the shell corresponding to the back cavity is provided with sapphire glass covering the installation hole, and the front cavity is in communication with the outside of the acoustic device through the sound outlet.

Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

Abstract: Methods, apparatus and systems for vehicle wireless monitoring are described. In one example, a described method comprises: transmitting a first wireless signal from a first wireless device through a wireless multipath channel of a venue, the venue comprising a vehicle and an immediate vicinity of the vehicle; receiving a second wireless signal by a second wireless device in the venue through the wireless multipath channel, wherein the second wireless signal differs from the first wireless signal due to the wireless multipath channel and a modulation by an object undergoing a motion in the venue; obtaining a time series of channel information (TSCI) of the wireless multipath channel based on the second wireless signal; and performing a monitoring task by monitoring, based on the TSCI, at least one of: the vehicle, the object or the motion of the object.

Abstract: Disclosed are a display screen assembly and a mobile terminal. The display screen assembly includes a transparent cover plate and a display module. The transparent cover plate includes a transparent region and a light-shielding region located at a side edge of the transparent region. The transparent region comprises a first inner surface, and the light-shielding region comprises a second inner surface connected to the first inner surface. The display module is stacked on the first inner surface of the transparent region. A charge blocking layer is arranged on at least a part of the second inner surface of the light-shielding region, and the charge blocking layer extends along two opposite side edges of the display module to block charges generated outside the mobile terminal from entering the display module.

Abstract: Therapeutic compositions deliver a therapeutic amount of methylphenidate in a delayed and extended release formulation. The dosage form exhibits a lag time prior to release of from 6 to 8 hours or longer, followed by a sustained release period.

Abstract: The present disclosure belongs to the field of display technology, and provides an optical module, a manufacturing method thereof, and a display device. The optical module includes: a substrate; a barrier structure arranged on the substrate; a black matrix arranged within the barrier structure, an orthogonal projection of the black matrix onto the substrate not going beyond a region surrounded by the barrier structure; and optical lenses arranged on a side of the black matrix away from the substrate. An orthogonal projection of a gap between adjacent optical lenses onto the substrate falls into the black matrix.

Abstract: The present application discloses a display panel and a preparation method thereof. The display panel includes a base substrate provided with a circuit area and a light-emitting area; a driving circuit located in the circuit area of the base substrate; an organic insulating layer covering the light-emitting area of the base substrate; a light-emitting element embedded in the organic insulating layer, where an overlap area between the orthographic projection of the light-emitting element on the base substrate and the orthographic projection of the driving circuit on the base substrate is 0; and a first lapping electrode located on the side, facing away from the base substrate, of the light-emitting element, where the light-emitting element is electrically connected to the driving circuit through the first lapping electrode.

Abstract: Transistors and integrated circuitry including a 2D channel material layer within a stack of material layers further including one or more insulator (e.g., dielectric) materials above and/or below the 2D channel material layer. These supporting insulator layers may be non-sacrificial while other material layers within a starting material stack may be sacrificial, replaced, for example, with gate insulator and/or gate material. In some exemplary embodiments, the 2D channel material is a metal chalcogenide and the supporting insulator layer is advantageously a dielectric material composition having a low dielectric constant.

Abstract: A hybrid powertrain includes a conversion device, a first motor, and an engine. At least one of the first motor and the engine is configured to output power to a driving end through the conversion device. The engine is configured to output power to the first motor through the conversion device, to drive the first motor to generate electricity.

Abstract: Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor.

Abstract: A sound generating panel, a display device with a screen generating sound and a method for manufacturing a sound generating panel are provided. The sound generating panel includes sound generating unit groups, each of which includes sound generating units. Each sound generating unit includes a support layer with openings and two piezoelectric structures resonating through a cavity, improving a sound pressure generated by the sound generating panel. Each sound generating unit group includes sound generating units with different radii, thereby realizing sound generating at different frequencies, and improving a sound effect of the sound generating panel. Each of some sound generating unit groups includes ultrasonic detection units for detecting a distance between a listener and the sound generating panel, so that an effect of automatically regulating and controlling a volume of sound is realized.