Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements.

Abstract: Described herein are integrated circuit devices that include both nanoribbon-based transistors and fin-shaped transistors. The nanoribbon transistors may have shorter channel lengths than the fin transistors. In addition, the nanoribbon transistors may have thinner gate dielectrics than the fin transistors.

Abstract: An aluminum alloy comprising aluminum, copper, cerium, and one or more of manganese and zirconium. The aluminum alloy comprises a copper:cerium ratio of about 2.0:1.0. Related methods of forming articles comprising the aluminum alloy and articles comprising the aluminum alloy are also disclosed.

Abstract: The subject matter disclosed herein is generally directed to methods of differentiating pluripotent cells into target cell types and screening platforms for systematically identifying transcription factors (TFs) that drive differentiation of pluripotent cells into target cell types. Also disclosed is a high-throughput multiplex screening platform. Also disclosed are in vitro models for neural progenitor cells and cardiomyocytes.

Abstract: The present application relates to an interferogram phase estimation method. The interferogram phase estimation method includes: obtaining an interferogram for estimation of a measured object; and inputting the interferogram for estimation to a neural network model trained based on a method for training a neural network model for interferogram phase estimation, to obtain a phase image corresponding to the interferogram for estimation. In the interferogram phase estimation method of the present application, features of different scales of an interferogram are learned based on a Unet++ neural network model to obtain an accurately estimated phase image corresponding to the interferogram.

Abstract: An electronic device includes a shell, a button member, a sleeve member, a waterproof ring, and a circuit board. The shell is made of a metal material, and the shell includes a mounting hole. The button member is made of a metal material, the button member includes a cap and a shaft body, the cap is located on an outer side of the shell, the shaft body passes through the mounting hole, and the shaft body includes a first end and a second end. The sleeve member is made of a heat shrinkable plastic material, and the sleeve member wraps the shaft body tightly. The waterproof ring is sleeved on the shaft body. The circuit board is disposed inside the shell, and the second end of the shaft body is movably in contact with or away from the circuit board.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.

Abstract: A mixing apparatus includes: a driving device configured to drive first liquid to flow into first transfer chamber and to drive second liquid to flow into second transfer chamber, a first transfer chamber configured to store inflowed first liquid, and a second transfer chamber configured to store inflowed second liquid; a premixing chamber communicating with liquid outlet of first transfer chamber and liquid outlet of second transfer chamber; and a monitor configured to monitor volume of liquid in first transfer chamber and volume of liquid in second transfer chamber, close liquid inlet of first transfer chamber and control first liquid to flow into premixing chamber when volume of first liquid is equal to first value, and close liquid inlet of second transfer chamber and control second liquid to flow into premixing chamber when volume of second liquid is equal to second value.

Abstract: The invention provides a micro-interface enhanced oxidation system and an oxidation method for preparing hydrogen peroxide, wherein the micro-interface enhanced oxidation system includes: an oxidation reactor, wherein a top portion of a side surface is provided with a liquid phase pipeline for delivering hydrogenated anthraquinone, and a bottom portion of the side surface is provided with a gas phase pipeline for delivering air; and a liquid distributor, a packing section, a seal pan and a hybrid micro-interface unit that are arranged in order from top to bottom are arranged in the oxidation reactor, wherein the hybrid micro-interface unit comprises a upper-mounted micro-interface generator and a lower-mounted micro-interface generator that are communicated with each other up and down, and the hydrogenated anthraquinone delivered in goes down in turn until being mixed with the air in the hybrid micro-interfacial unit to be dispersed and crushed after being distributed through the liquid distributor.

Abstract: Fabrication method for nanoribbon-based transistors and associated transistor arrangements, IC structures, and devices are disclosed. An example fabrication method is based on patterning a foundation over which a superlattice is provided so that a single superlattice may be used to form both PMOS and NMOS stacks of nanoribbons. An example IC structure includes a support, an NMOS stack of nanoribbons stacked vertically above one another over the support, and a PMOS stack of nanoribbons stacked vertically above one another over the support, wherein at least one of the nanoribbons of the NMOS stack is vertically offset with respect to at least one of the nanoribbons of the PMOS stack.

Abstract: An encryption method includes: receiving cipher data which is binary data; determining target components in a resistive memory array according to values of respective bits in the cipher data; determining current values generated by respective columns of components according to the target components; and generating key data according to the current values generated by the respective columns of components. The present disclosure can effectively reduce computing power and power consumption of an encryption process in an edge device.

Abstract: An IC device includes a backside FTI separating a first transistor from a second transistor. The FTI may be between a source region of the first transistor and a drain region of the second transistor. The source region of the first transistor and the drain region of the second transistor may be different portions of a semiconductor structure, e.g., a fin or nanoribbon. The IC device may also include a frontside metal layer. The semiconductor structure may have a first surface and a second surface opposing the first surface. The first surface of the semiconductor structure may be closer to the metal layer and larger than the second surface of the semiconductor structure. The FTI may have a first surface and a second surface opposing the first surface. The first surface of the FTI may be closer to the metal layer but smaller than the second surface of the FTI.

Abstract: A phase shifter, a manufacturing method thereof and an electronic device are provided. The phase shifter includes opposite first and second substrates, and a tunable dielectric layer and first isolation components therebetween. The first substrate includes a first dielectric substrate and a first electrode on a side of the first dielectric substrate close to the tunable dielectric layer; the second substrate includes a second dielectric substrate and a second electrode on a side of the second dielectric substrate close to the tunable dielectric layer; the phase shifter includes a phase shift region and a peripheral region; the phase shift region includes overlapping regions; the first electrode and the second electrode are both in the phase shift region, and orthographic projections of the first electrode and the second electrode on the first dielectric substrate at least partly overlap with each other in the overlapping regions, to form overlapping capacitors.

Abstract: The present disclosure relates to a liquid crystal phase shifter, a method for operating the liquid crystal phase shifter and an antenna. The liquid crystal phase shifter includes a first substrate, a second substrate, a liquid crystal layer and at least one adjustment unit. The one of the at least one adjustment unit includes a first electrode, a second electrode and a control circuit. The control circuit comprises a driving sub-circuit, a switching sub-circuit and a reset sub-circuit. The driving sub-circuit is configured to input a voltage to the first electrode. The reset sub-circuit is configured reset a voltage of a control terminal of the driving sub-circuit.

Abstract: An expansion apparatus for incorporating with a computing device and a computing system including the expansion apparatus are disclosed. The computing device includes a first OPS port. The expansion apparatus includes: a second OPS port configured for coupling to the first OPS port of the computing device; and a network adapter configured for connecting the computing device to a network, wherien the network adapter is connected with a data terminal of the second OPS port for data communication.

Abstract: A metal gate fabrication method for nanoribbon-based transistors and associated transistor arrangements, IC structures, and devices are disclosed. An example IC structure fabricated using metal gate fabrication method described herein may include a first stack of N-type nanoribbons, a second stack of P-type nanoribbons, a first gate region enclosing portions of the nanoribbons of the first stack and including an NWF material between adjacent nanoribbons of the first stack, and a second gate region enclosing portions of the nanoribbons of the second stack and including a PWF material between adjacent nanoribbons of the second stack, where the second gate region includes the PWF material at sidewalls of the nanoribbons of the second stack and further includes the NWF material so that the PWF material is between the sidewalls of the nanoribbons of the second stack and the NWF material.

Abstract: Provided are a phase shifter, a method for manufacturing the same, and an electronic device. The phase shifter includes: a first substrate and a second substrate that are oppositely arranged, and heat conduction structures arranged between the first substrate and the second substrate. Orthographic projections of the heat conduction structures and orthographic projections of phase shifting units on the same substrate do not overlap each other.

Abstract: Novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.