Abstract: The disclosure belongs to the field of monitoring equipment and provides an automobile dual-camera monitor system, including a first camera, a second camera, a transmission line and a display, the first camera and the second camera being fixed in an automobile through a first fixing assembly and a second fixing assembly respectively, and a camera end of each of the first camera and the second camera facing a front end of a safety seat.

Abstract: A microlens array substrate (200) and a preparation method therefor, and a display device. The microlens array substrate (200) comprises: a base; a microlens film layer disposed on a side of the base and comprising at least one microlens array, the microlens array comprises a plurality of microlenses and a spacer portion between adjacent microlenses; a barrier layer disposed on a side of the microlens film layer away from the base, an orthographic projection of at least part of the barrier layer on the base is overlapped with an orthographic projection of the microlenses on the base; a light shielding layer disposed on a side of the microlens film layer away from the base and comprising at least one light shielding pattern, an orthographic projection of the at least one light shielding pattern on the base is overlapped with an orthographic projection of the spacer portion on the base.

Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

Abstract: Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Abstract: A production line for producing components to a high standard of cleanliness and sealed and protected in that state includes a loading device, a cleaning device, a detecting device, a pasting device, a heat-sealing device, a packing device, and transfer devices of the production line. The production line automatically processes the components for obtaining components with the high cleanliness. By the processes of protective film pasting, heat-sealing, and packing, the components may be further protected from subsequent pollution. A method for producing components with a high cleanliness applied to the production line is also disclosed.

Abstract: A wearable device includes: a main structure, two straps, a connecting piece and a driving structure. The two straps are respectively connected to two ends of the main structure; the connecting piece is provided with a mounting cavity, a slide cavity in communication with the mounting cavity, and two communicating ports, each of the two straps having one end thereof distal to the main structure movably passing through one of the communicating ports to extend into the slide cavity, and the main structure, the two straps and the connecting piece enclosing a wearable space: the driving assembly is provided in the mounting cavity, the two transmission parts being provided spaced apart in the slide cavity and in transmission connection with the driving assembly, each of the two transmission parts being in respective transmission connection with the two straps.

Abstract: A timed gas cut-off device, which comprises a device body, comprising an inlet gas channel, an outlet gas channel and a valve rod channel; the inlet and outlet gas channels are respectively in communication with the valve rod channel, an accommodation chamber with a through hole communicating the accommodation chamber with the valve rod channel; a valve rod device, comprising a rod body slidably cooperating in the valve rod channel, a shim connected to the rod body and moves in synchronization with the rod body to open or close the valve rod channel; a free end of the rod body extends through the through hole and disposed inside the accommodation chamber; an elastic soft sealing piece, sealingly connected to the through hole, sleeved on the free end of the rod body; a timer with a drive piece connected inside the accommodation chamber for timed gas use and improves the safety.

Abstract: The present invention relates to in vivo methods for modeling tumor formation and/or tumor evolution comprising the use of eukaryotic cells in which one or more genetic target locus has been altered by the CRISPR/Cas system, and which cells are transplanted in non-human eukaryote as a model system for tumor formation and tumor evolution. In particular in vivo genetic screening methods for identifying genes involved in tumorigenesis and metastasis are disclosed. The invention further relates to kits and components for practicing the methods, as well as materials obtainable by the methods, in particular tumor and metastasis samples and cells or cell lines derived therefrom. The invention also relates to diagnostic and therapeutic methods derived from the information obtained in the modeling methods.

Abstract: An interactive system includes a terminal, a display screen and a server, the server determines a current position of a target object on the display screen; generates an object identifier of the target object according to the current position thereof object, and associates the object identifier with the current position; receives adjustment information of the target object, generates an indication pattern according to the current position and the adjustment information, and transmits the indication pattern to the display screen; the terminal displays a frame image configured for the display screen, displays the object identifier according to an association relationship between the object identifier and the current position; generates adjustment information of the target object in response to an arrangement operation of a user on the object identifier; the display screen displays the indication pattern to instruct the target object to adjust according to an indication of the indication pattern.

Abstract: Disclosed is a fast self-adaptive rotary plug-in underwater force-bearing connector, which comprises a plug part and a socket part, wherein the plug part comprises a plug housing, a pin arranged in the plug housing, and a push-pull sleeve, a rotary sleeve, a front retaining ring, a ratchet lock nut and a rear retaining ring arranged outside the plug housing; the socket part comprises a socket housing and a jack arranged in the socket housing; the pin and the jack cooperate to connect the plug part and the socket part. The fast self-adaptive rotary plug-in underwater force-bearing connector of the present application can work under the working condition of a large tensile force and has a high reliability.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The present invention is directed to compositions having chair-side handling properties comprising polymers for dental, soft tissue and combination products applications.

Abstract: Systems and methods for rapid diagnostics related to the use of combinations of CRISPR effector systems with optimized guide sequences, OSD probes, RNA probes and/or RNase H for detection of nucleic acid sequences, such as sequences from coronavirus, as well as multiplex lateral flow diagnostic devices and methods of use, are provided.

Abstract: A high-magnetic-induction low-iron-loss non-oriented silicon steel sheet and a manufacturing method therefor. The chemical composition by mass percentages is: C?0.005%, Si: 0.1%-1.6%, Mn: 0.1%-0.5%, P?0.2%, S?0.004%, Al?0.003%, N?0.005%, Nb?0.004%, V?0.004% and Ti?0.003%, with the balance being Fe and inevitable impurities; and at the same time satisfies: 120?[Mn]/[S]?160, and [Nb]/93+[V]/51+[Ti]/48+[Al]/27?[C]/12+[N]/14. After casting, the cooling rate in a cool-down process of casting slab is controlled, and a temperature controlling method is used to adjust the charging temperature of casting slab.

Abstract: An encryption method includes: receiving cipher data which is binary data; determining target components in a resistive memory array according to values of respective bits in the cipher data; determining current values generated by respective columns of components according to the target components; and generating key data according to the current values generated by the respective columns of components. The present disclosure can effectively reduce computing power and power consumption of an encryption process in an edge device.

Abstract: An IC device may include an array of transistors. The transistors may have separate gate electrodes. A gate electrode may include polysilicon. The gate electrodes may be separated from each other by one or more electrical insulators. The separated gate electrodes have shorter lengths, compared with connected gate electrodes, which can optimize the performance of the IC device due to local layout effect. Also, the IC device may include conductive structures crossing the support structures of multiple transistors. Such conductive structures may cause strain in the IC device, which can boost the local layout effect. The conductive structures may be insulated from a power plane. Alternatively or additionally, the IC device may include dielectric structures, which may be formed by removing gate electrodes in some of the transistors and providing a dielectric material into the openings. The presence of the dielectric structures can further boost the local layout effect.

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements.

Abstract: An IC device may have layout with reduced N-P boundary effect. The IC device may include two rows of transistors. The first row may include one or more P-type transistors. The second row may include N-type transistors. The gate electrode of a P-type transistor may include different conductive materials from the gate electrode of a N-type transistor. Each P-type transistor in the first row may be over a N-type transistor in the second row and contact the N-type transistor in the second row. For instance, the gate of the P-type transistor may contact the gate of the N-type transistor. Vacancy diffusion may occur at the boundary of the P-type transistor and the N-type transistor, causing N-P boundary effect. At least one or more other N-type transistors in the second row do not contact any P-type transistor, which can mitigate the N-P boundary effect in the IC device.