Patents by Inventor Fenge ZHANG

Fenge ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250258054
    Abstract: There is provided a pressure sensor, including a top cover assembly, an upper seat (120), and a movable membrane (200); each of a top and a bottom of the upper seat (120) is provided with an opening, the top cover assembly seals the opening at the top of the upper seat, and the movable membrane (200) seals the opening at the bottom of the upper seat (120); the top cover assembly, the upper seat (120), and the movable membrane (200) form a pressure reference chamber (100), and the pressure sensor detects a gas pressure on a side of the movable membrane (200) away from the top cover assembly based on a state of the movable membrane (200); at least one gas guide passage (510) is formed at the top cover assembly, and is configured to connect the pressure reference chamber (100) to the outside; the top cover assembly includes at least one blocking member (521) configured to seal the gas guide passage (510); and the blocking member (521) seals the gas guide passage (510) after being heated to a temperature higher t
    Type: Application
    Filed: May 5, 2023
    Publication date: August 14, 2025
    Inventors: Feng ZHANG, Changhua MOU, Di ZHAO, Lei HU, Chen SUI, Qi WANG, Xiao LI, Zhaoxing LI, Qingli YANG, Zhen PENG, Bowen DENG
  • Publication number: 20250250577
    Abstract: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPIR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
    Type: Application
    Filed: January 16, 2025
    Publication date: August 7, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Le Cong, Randall Jeffrey Platt, Neville Espi Sanjana, Fei Ran
  • Publication number: 20250250578
    Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.
    Type: Application
    Filed: January 17, 2025
    Publication date: August 7, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventor: Feng Zhang
  • Publication number: 20250250589
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
    Type: Application
    Filed: January 16, 2025
    Publication date: August 7, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventor: Feng ZHANG
  • Publication number: 20250250618
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
    Type: Application
    Filed: January 17, 2025
    Publication date: August 7, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh, Ian Slaymaker
  • Publication number: 20250250151
    Abstract: Embodiments of the present application disclose a local map updating method and apparatus, and an electronic device, including: acquiring key-frame point cloud data, where the key-frame point cloud data includes point cloud coordinate points; matching the key-frame point cloud data with a prior map to determine target voxels, in the prior map, corresponding to the point cloud coordinate points; and updating a point cloud probability distribution corresponding to each target voxel according to a first map coordinate point and a second map coordinate point included in each target voxel to obtain a target map, where the first map coordinate point is obtained by converting the point cloud coordinate point corresponding to the target voxel, and the second map coordinate point is a coordinate point included in the target voxel in the prior map.
    Type: Application
    Filed: January 31, 2025
    Publication date: August 7, 2025
    Inventors: Fan ZHENG, Cheng ZHANG, Yujie LU, Feng ZHANG, Jiang LIU
  • Publication number: 20250250617
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
    Type: Application
    Filed: January 17, 2025
    Publication date: August 7, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh, Ian Slaymaker
  • Publication number: 20250250553
    Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system.
    Type: Application
    Filed: January 16, 2025
    Publication date: August 7, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Le Cong, Patrick Hsu, Fei Ran
  • Patent number: 12378623
    Abstract: The present invention discloses a Cu-containing non-oriented electrical steel plate having high cleanliness, comprising the following chemical elements in percentage by mass: 0<C?0.003%; Si: 0.1-2.0%; Mn: 0.1-0.55%; S: 0-0.004%; Cu: 0.003-0.2%; Al: 0.1-1.0%; and the balance being Fe and inevitable impurities. In addition, the present invention further discloses a continuous annealing process for the Cu-containing non-oriented electrical steel plate having high cleanliness. Moreover, the present invention further discloses a manufacturing method for Cu-containing non-oriented electrical steel plate having high cleanliness, including the steps of: smelting and casting; hot rolling; normalizing; cold rolling; performing the continuous annealing process; and applying an insulation coating to obtain a finished non-oriented electrical steel plate. The Cu-containing non-oriented electrical steel plate having high-cleanliness is high in cleanliness and excellent in magnetic performance.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: August 5, 2025
    Assignee: BAOSHAN IRON & STEEL CO., LTD
    Inventors: Feng Zhang, Bo Wang, Kanyi Shen, Baojun Liu, Guobao Li, Shuangjie Chu
  • Patent number: 12378588
    Abstract: The present invention discloses a transaminase mutant and application thereof in preparation of sitagliptin intermediates, the transaminase mutant is obtained by substitution of tyrosine with proline at position 74, substitution of glutamic acid with aspartic acid at position 228, substitution of leucine with alanine at position 254 and substitution of methionine with threonine at position 290 of the amino acid sequence shown in SEQ ID NO: 2. The present invention uses wet cells or a purified transaminase as a biocatalyst and a sitagliptin precursor ketone or a prochiral carbonyl compound as a substrate to prepare a sitagliptin intermediate or a sitagliptin ester intermediate; the total yield of the method reaches about 82%, and e.e. value of the product reaches 99%.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: August 5, 2025
    Assignees: ZHEJIANG YONGTAI TECHNOLOGY CO., LTD., ZHEJIANG UNIVERSITY OF TECHNOLOGY, ZHEJIANG YONGTAI PHARMACEUTICAL CO., LTD.
    Inventors: Zhiqiang Liu, Feng Cheng, Xiaojian Zhang, Dongxu Jia, Yuguo Zheng, Renbao He, Yizhong Jin, Hongming Shao, Jiaohua Lin, Feng Zhang
  • Publication number: 20250243471
    Abstract: Described in several example embodiments herein are engineered programmable pattern recognition compositions and uses thereof. In an embodiment, the engineered protein contains an NTPase of a Signal Transduction ATPases with Numerous-associated Domains (STAND) superfamily (STAND NTPase), comprising a pathogen-associated molecular pattern (PAMP) recognition activity, wherein the STAND NTPase and the PAMP recognition activity are derived from the same or different prokaryotes.
    Type: Application
    Filed: January 29, 2025
    Publication date: July 31, 2025
    Inventors: Feng Zhang, Alex Gao, Max Wilkinson, Jonathan Strecker
  • Publication number: 20250243248
    Abstract: Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.
    Type: Application
    Filed: April 11, 2025
    Publication date: July 31, 2025
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan
  • Patent number: 12371737
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: July 29, 2025
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh, Ian Slaymaker
  • Publication number: 20250235399
    Abstract: Described herein are dry powder inhalation mixtures for pulmonary delivery and processes for making the same. A process for making a dry powder inhaler blend as described herein comprises introducing an active pharmaceutical ingredient, a lubricant, and a carrier into a multi-screw extruder; and continuously mixing the active pharmaceutical ingredient, the lubricant, and the carrier in the multi-screw extruder to form a dry powder inhaler blend. In this method, the active pharmaceutical ingredient, the lubricant, and the carrier are in the form of a powder.
    Type: Application
    Filed: April 7, 2023
    Publication date: July 24, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Hugh Smyth, Feng Zhang, Jamie Spahn
  • Publication number: 20250236856
    Abstract: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.
    Type: Application
    Filed: January 16, 2025
    Publication date: July 24, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Fei Ran, Ophir Shalem
  • Publication number: 20250236857
    Abstract: Chimeric, engineered DNA-targeting IscB systems, methods and compositions including novel chimeric IscB polypeptides and reprogrammable targeting nucleic acid components and methods and application of use are provided.
    Type: Application
    Filed: November 22, 2024
    Publication date: July 24, 2025
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan
  • Publication number: 20250233372
    Abstract: An electrical connector includes an insulating housing, a plurality of conductive terminals and two detecting terminals. The plurality of the conductive terminals are fastened in the insulating housing. Each conductive terminal has a first fastening portion. A front end of the first fastening portion extends frontward to form a contacting portion. The contacting portion is exposed to a front end of the insulating housing. The plurality of the conductive terminals include two power terminals and a plurality of signal terminals. The two detecting terminals are fastened in the insulating housing. Each detecting terminal is disposed between one signal terminal and one power terminal.
    Type: Application
    Filed: August 13, 2024
    Publication date: July 17, 2025
    Inventors: YUN-FENG ZHANG, ZHI-BIN DONG, CHEN SUN
  • Publication number: 20250225116
    Abstract: A data processing method and apparatus are disclosed, wherein the data processing method is applied to a metadata management node in a distributed file system, including: determining a directory level of metadata to be processed in a directory tree, and assigning an array identifier to the metadata to be processed based on the directory level; and constructing a metadata management table corresponding to the metadata to be processed based on the array identifier and metadata in the directory tree, and managing the directory tree based on the metadata management table. Dividing of the metadata management table and the directory tree is implemented by means of the data identifier, which can achieve efficient metadata management.
    Type: Application
    Filed: March 24, 2023
    Publication date: July 10, 2025
    Applicant: Cloud Intelligence Assets Holding (Singapore) Private Limited
    Inventors: Feng ZHANG, Li XU, Qiangqiang WU
  • Patent number: D1086138
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: July 29, 2025
    Assignee: Shenzhen Vaydeer Technology Co., Ltd.
    Inventor: Feng Zhang
  • Patent number: D1086148
    Type: Grant
    Filed: January 16, 2023
    Date of Patent: July 29, 2025
    Assignee: Shenzhen Vaydeer Technology Co., Ltd.
    Inventor: Feng Zhang