Abstract: A magnetic stand includes: a base having an insertion hole into which a container is to be inserted, the insertion hole extending along a first axis; and a magnet provided on the base and having a magnetization that applies a magnetic field to the insertion hole. The magnet is disposed such that magnetic poles thereof face directions different from that of the container. When a plane including the first axis and determined such that a normal line of the plane is orthogonal to the first axis and passes through a center of the magnet is taken as a reference plane, and the magnetization is projected onto the reference plane, an angle formed by the first axis and the magnetization projected onto the reference plane is more than 0° and 90° or less.

Abstract: A pressure-sensitive sensor includes a first electrode, a second electrode, and a conductive resin located between the first electrode and the second electrode, wherein the conductive resin includes a first region, and a second region different from the first region in thickness in a direction in which the first electrode and the second electrode are arranged, and the second region surrounds the first region. Further, the thickness of the second region is thicker than the thickness of the first region. Further, a center of the first electrode is located within the first region in a plan view from the direction in which the first electrode and the second electrode are arranged.

Abstract: A pressure-sensitive sensor includes a first electrode, a second electrode, and a conductive resin located between the first electrode and the second electrode, wherein the conductive resin includes a first region, and a second region different from the first region in thickness in a direction in which the first electrode and the second electrode are arranged, and the second region surrounds the first region. Further, the thickness of the second region is thicker than the thickness of the first region. Further, a center of the first electrode is located within the first region in a plan view from the direction in which the first electrode and the second electrode are arranged.

Abstract: A pressure-sensitive device includes a resin mixture in which a carbon nanotube is mixed, an electrode stacked on the resin mixture, and a pressurization unit that pressurizes the resin mixture in a direction of the stacking, wherein the pressurization unit includes an adjustment mechanism of adjusting an amount of the pressurization. Further, the pressurization unit has a first board, a second board placed along a direction of stacking on the first board, and a screw as the adjustment mechanism, and a distance between the first board and the second board changes by turning of the screw, and thereby, the amount of pressurization is adjusted.

Abstract: A container assembly prevents a situation in which an aqueous liquid layer is contaminated by a component of another aqueous liquid layer even when stored for a long time. A container assembly has a structure in which an adsorption container, a reaction container, a washing container, and an elution container are joined to form a flow channel through which the target nucleic acid is moved. The washing container may include a first washing container, a second washing container, and a third washing container. The washing containerseal-tightly holds a first washing liquid, a second washing liquid, a third washing liquid, a first oil, a second oil, a third oil, and a fourth oil, the first oil, the second oil, the third oil, and the fourth oil being immiscible with the first washing liquid, the second washing liquid, and the third washing liquid. The first washing liquid, the second washing liquid, and the third washing liquid are liquids with which a magnetic bead on which a nucleic acid is adsorbed is washed.

Abstract: A substance purification device ensures that the interface between an aqueous liquid layer and an oil-based liquid layer is maintained in a stable manner.

Abstract: A nucleic acid-binding solid-phase carrier includes a magnetic particle of an amorphous metal containing Fe, Cr, Si, and B, and a silicon oxide film provided on the surface of the magnetic particle.

Abstract: A nucleic acid amplification reaction container includes: a flow path which is formed between a first inner wall surface and a second inner wall surface that opposes the first inner wall surface, and has the longitudinal direction in the direction along the first inner wall surface, in which the distance between the first inner wall surface and the second inner wall surface is the distance by which nucleic acid amplification reaction liquid comes into contact with both of the first inner wall surface and the second inner wall surface in a case where the nucleic acid amplification reaction liquid is guided therein, and in which, in the section which is orthogonal to the longitudinal direction of the flow path, the length in the direction parallel to the first inner wall surface is 5 times or more the distance between the first inner wall surface and the second inner wall surface.

Abstract: A biologically relevant material purification cartridge includes: a syringe which has a first portion and a second portion with a smaller inner diameter than that of the first portion; a plunger which has a cylindrical section capable of being fitted to an inner peripheral surface of the first portion and a rod-shaped section supported by the cylindrical section and capable of being fitted to an inner peripheral surface of the second portion, and can be inserted from the side of the first portion of the syringe, and can move in the insertion direction with respect to the syringe; and a cap which has a vent hole for communicating the internal space of the cylindrical section with the outside and a breathable sheet disposed to close the vent hole, and is connected to the cylindrical section.

Abstract: A biochip used for quantitative analysis of a target DNA contained in a sample. The biochip includes a type I chamber that includes a primer designed to bind to the target DNA, an internal standard DNA of a first amount that has a sequence different from a sequence of the target DNA, and is amplifiable with the primer, and a fluorescent probe that is designed to bind to a part of a PCR product of the target DNA and to a part of a PCR product of the internal standard DNA. The fluorescent probe fluoresces differently for the PCR product of the target DNA and the PCR product of the internal standard DNA. The biochip also includes a type II chamber that includes the internal standard DNA of a second amount, the primer, and the fluorescent probe. The first and second amounts are different.

Abstract: A cDNA synthesis method includes: mixing a lysis solution containing a chaotropic substance and a nucleic acid-binding solid-phase carrier in a sample containing a ribonucleic acid (RNA), thereby adsorbing the RNA on the carrier; reverse-transcribing the RNA adsorbed on the carrier while keeping the RNA adsorbed on the carrier in a reverse transcription reaction mixture, thereby synthesizing cDNA; and eluting the synthesized cDNA with an eluent.

Abstract: A biochip used for quantitative analysis of a target DNA contained in a sample. The biochip includes a type I chamber that includes a primer designed to bind to the target DNA, an internal standard DNA of a first amount that has a sequence different from a sequence of the target DNA, and is amplifiable with the primer, and a fluorescent probe that is designed to bind to a part of a PCR product of the target DNA and to a part of a PCR product of the internal standard DNA. The fluorescent probe fluoresces differently for the PCR product of the target DNA and the PCR product of the internal standard DNA. The biochip also includes a type II chamber that includes the internal standard DNA of a second amount, the primer, and the fluorescent probe. The first and second amounts are different.

Abstract: A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the rotational axis is shorter than the distance between the other end portion of the biotip and the rotational axis, a heating unit heats a first end portion of the biotip, a rotating unit rotates the holder, and a controller that controls the rotation speed of the rotating unit. The controller has a first mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes smaller than the gravity, and a second mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes greater than the gravity.

Abstract: A nucleic acid extraction device includes a tube that is internally provided with, in the following order, a first plug composed of a first oil, a second plug composed of a first washing liquid, which is phase-separated from an oil and is used for washing a nucleic acid-binding solid-phase carrier having nucleic acids bound thereto, a third plug composed of a second oil, a fourth plug composed of a reverse transcription reaction solution, which is phase-separated from an oil and is used for performing a reverse transcription reaction, a fifth plug composed of a third oil, a sixth plug composed of an eluent, which is phase-separated from an oil and is used for eluting the nucleic acids from the nucleic acid-binding solid-phase carrier having nucleic acids bound thereto, and a seventh plug composed of a fourth oil.

Abstract: A nucleic acid amplification reaction apparatus including a first heating section and a second heating section configured to heat a first region and a second region of a container respectively to a first temperature and a second temperature, higher than the first temperature, and a driving mechanism configured to switch the arrangement of the first and second regions in the order of first arrangement, second arrangement, and third arrangement. The first arrangement and the third arrangement are arrangement in which the first region is below the second region in a direction in which the gravity acts. The second arrangement is arrangement in which the second region is below the first region in the direction in which the gravity acts. The container includes a projecting section where an inner wall of the container projects outward and is configured to enable the reaction liquid to stay therein in the third arrangement.

Abstract: A nucleic acid amplification reaction apparatus including a first heating section to heat a first region of a container filled with reaction liquid and liquid and a second heating section to heat a second region of the container to temperature higher than the temperature of the first heating section, first arrangement is arrangement in which the first region is below the second region in a direction in which the gravity acts and the second arrangement is arrangement in which the second region is below the first region. Third arrangement is arrangement in which an axis in the longitudinal direction of the container is horizontal or arrangement in which the axis inclines with respect to the vertical line and the second region is below the first region. A driving mechanism switches the first arrangement, the second arrangement, and the third arrangement in this order.

Abstract: A dispensing method which dispenses a first liquid contained in a first vessel which stores the first liquid and a second liquid to introduce the first liquid into a second vessel by using a tube.

Abstract: The present invention provides a method of manipulating a solid carrier and an apparatus of manipulating a solid carrier in which the solid carrier is passed through more regions in liquid in a vessel. More specifically, the method of manipulating the solid carrier is a method of manipulating a solid carrier in a liquid contained in a vessel, the solid carrier being magnetic and capable of carrying a substance, the method comprising: manipulating the solid carrier using a magnetic force application unit adapted to applying a magnetic force to the solid carrier in the vessel so that the relative position between the magnetic force application unit and the vessel is altered over a period of time by means of directing the solid carrier in a direction along either one or a combination of the vectors of the longitudinal direction of the vessel and the direction crossing the longitudinal direction of the vessel.

Abstract: A cartridge for a nucleic acid amplification reaction includes a tube which has a longitudinal direction and has, in the inside thereof, an elution solution plug formed of an elution solution, which undergoes phase separation from oil and causes nucleic acid to be eluted from particulates bound to the nucleic acid, and a plug of a first liquid formed of oil and a first additive, and a nucleic acid amplification reaction container which communicates with the tube, and the nucleic acid amplification reaction container contains a second liquid formed of oil and a second additive. The concentration of the first additive contained in the first liquid is higher than the concentration of the second additive contained in the second liquid.

Abstract: A nucleic acid analysis device includes a mounting portion supporting a nucleic acid amplification reaction container, first and second heaters which heat first and second portions of the container, a rotating mechanism which collectively rotates the container and heaters, a heater controller, a rotating mechanism controller, a fluorescence measurer, and a nucleic acid melting curve analyzer. The container is repeatedly inverted while a nucleic acid amplification reaction cycle occurs therein. The first and second heaters heat the container such that the first portion reaches a first temperature and the second portion reaches a second temperature while the nucleic acid amplification reaction cycle occurs. After the nucleic acid amplification reaction cycle ends, the second heater increases the temperature of the second portion. The fluorescence emitted from the amplified nucleic acid is measured while the temperature of the second portion increases.