Abstract: CD73 (also known as ecto-5?-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I and pharmaceutically acceptable esters or salts thereof.

Abstract: A gate stack can be etched to form a trench extending through the gate stack, the trench removing a portion of the gate stack to separate the gate stack into a first gate stack portion and a second gate stack portion. A dielectric material is deposited in the trench to form a dielectric region, the dielectric region having an air gap in the dielectric material. The air gap may extend upward from beneath the gate stack to an area interposed between the end of the first gate stack portion and the end of the second gate stack portion. Contacts to the first gate stack portion and contacts to the second gate stack portion may be formed which are electrically isolated from each other by the dielectric material and air gap formed therein.

Abstract: This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antibodies including bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing an expression-enhancing locus.

Abstract: An ultrasound fetal imaging system uses an acceleration sensor (16) for generating an acceleration signal relating to movement of the ultrasound transducer (10). A user is guided in how or where to move the ultrasound transducer based on the results of image processing of the ultrasound images. The user can thus be guided to move the transducer in a certain direction so as to achieve a complete scan of a fetus in a shortest possible time. This limits exposure of the expectant mother to the ultrasound energy. The fetal image obtained may be used to determine a fetal weight, for example using regression analysis based on some of the parameters derived from the obtained image.

Abstract: A back contact structure includes: a silicon substrate including a back surface including a plurality of recesses disposed at intervals; a plurality of first conductive regions and a plurality of second conductive regions disposed alternately on the back surface of the silicon substrate; a second dielectric layer disposed between the plurality of first conductive regions and the plurality of second conductive regions; and a conductive layer disposed on the plurality of first conductive regions and the plurality of second conductive regions. One of the plurality of first conductive regions and the plurality of second conductive regions is disposed inside the plurality of recesses, respectively, and the other one is disposed outside the plurality of recesses; each first conductive region includes a first dielectric layer and a first doped region which are disposed successively, and each second conductive region includes a second doped region.

Abstract: Disclosed herein are bone marrow stromal cells. The bone marrow stromal cells may express and/or secrete TGF-?1. The bone marrow stromal cells may express CXCR4. Also disclosed herein is a method of treating pain in a subject in need thereof. The method of treating may include administration of the bone marrow stromal cells to the subject. The pain may be neuropathic pain.

Abstract: A back contact structure includes: a silicon substrate including a back surface including a plurality of recesses disposed at intervals; a first dielectric layer disposed on the back surface of the silicon substrate; a plurality of first doped regions disposed on the first dielectric layer and disposed inside the plurality of recesses; a plurality of second doped regions disposed on the first dielectric layer and disposed outside the plurality of recesses; a second dielectric layer disposed between the first doped regions and the second doped regions; and a conductive layer disposed on the first plurality of doped regions and the plurality of second doped regions.

Abstract: A back contact structure of a solar cell, includes: a silicon substrate, the silicon substrate including a back surface including a plurality of recesses disposed at intervals; a plurality of first conductive regions and a plurality of second conductive regions disposed alternately in the plurality of recesses, where each first conductive region includes a first dielectric layer and a first doped region which are disposed successively in the plurality of recesses, and each second conductive region includes a second doped region; a second dielectric layer disposed between the plurality of first conductive regions and the plurality of second conductive regions; and a conductive layer disposed on the plurality of first conductive regions and the plurality of second conductive regions.

Abstract: A method of user data authorization based on blockchain includes: storing, by a first application client, encrypted user data of user data in a blockchain database through a blockchain node, generating authorization information in response to a request of acquiring the user data by a second application client, and notifying the second application client to obtain the authorization information such that the second application client obtains the user data based on the encrypted user data and the authorization information. The encrypted user data is stored in the blockchain database such that the encrypted user data cannot be tampered with and a leak of real user data is prevented. The second application client obtains the user data based on the authorization information and the encrypted user data.

Abstract: Disclosed in the present utility model are an electric tool and a method for operating same. The electric tool comprises a power supply input, a motive power system, a control system and at least one control button, the motive power system comprising a motor and an operating component driven by the motor, the control system comprising a circuit module to which the at least one control button is electrically connected, wherein the control system is configured to selectively supply electric power to the circuit module or cut off electric power to the circuit module, and adjust an output power of the motive power system, based on the number of times that the at least one control button is operated.

Abstract: This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing multiple expression-enhancing locus.

Abstract: Transistors having nonplanar electron channels in the channel width plane have one or more features that cause the different parts of the nonplanar electron channel to turn on at substantially the same threshold voltage. Advantageously, such transistors have substantially uniform threshold voltage across the nonplanar electron channel. Devices, image sensors, and pixels incorporating such transistors are also provided, in addition to methods of manufacturing the same.

Abstract: Transistors include a pyramid-shaped gate trench defined by a triangular shape or a trapezoidal shape in a channel width plane and a trapezoidal shape in a channel length plane. Side wall portions of the pyramid-shaped gate trench form a channel having a triangular shape or a trapezoidal shape in the channel width plane. Advantageously, such transistors increase transconductance without increasing pixel width. Devices, image sensors, and pixels incorporating such transistors are also provided, in addition to methods of manufacturing the same.

Abstract: The present invention provided an oligonucleotide targeting the core editing-site complementary sequence (ECS) of AZIN1 gene, wherein the core ECS of AZIN1 gene comprises the sequence 5?-GCTTTTCC-3?, and wherein the oligonucleotide comprises one or more nucleotides with sugar modification and one or more modified internucleotide linkages. In another aspect, there is provided a pharmaceutical composition comprising the oligonucleotide as disclosed herein. In another aspect, there is provided a method of inhibiting AZIN1 pre-mRNA editing in a cell, wherein the AZIN1 pre-mRNA editing is mediated by adenosine deaminase acting on RNA-1 (ADAR-1), as well as a method of using the same for the treatment of cancers associated with AZIN1 pre-mRNA editing, including liver cancer.

Abstract: Transistors having nonplanar electron channels in the channel width plane have one or more features that cause the different parts of the nonplanar electron channel to turn on at substantially the same threshold voltage. Advantageously, such transistors have substantially uniform threshold voltage across the nonplanar electron channel. Devices, image sensors, and pixels incorporating such transistors are also provided, in addition to methods of manufacturing the same.

Abstract: A nanogrid and a virtual inverter controller for the nanogrid are disclosed. The nanogrid includes at least one parallel branch, and at least one branch is equipped with a protector. At least one of the protectors is equipped with one virtual inverter controller. The virtual inverter controller includes a sensor component configured to detect at least one characteristic parameter on the branch, and a control component affecting the electrical connection state of the corresponding protector of the virtual inverter controller according to the characteristic parameter.

Abstract: An embodiment includes a method including forming an opening in a cut metal gate region of a metal gate structure of a semiconductor device, conformally depositing a first dielectric layer in the opening, conformally depositing a silicon layer over the first dielectric layer, performing an oxidation process on the silicon layer to form a first silicon oxide layer, filling the opening with a second silicon oxide layer, performing a chemical mechanical polishing on the second silicon oxide layer and the first dielectric layer to form a cut metal gate plug, the chemical mechanical polishing exposing the metal gate structure of the semiconductor device, and forming a first contact to a first portion of the metal gate structure and a second contact to a second portion of the metal gate structure, the first portion and the second portion of the metal gate structure being separated by the cut metal gate plug.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: A fine blanking device and method for forming a friction plate with friction material layers. The fine blanking device includes an upper die, a lower die, a guide mechanism, a punch and a counter punch. Upper and lower blank holders are respectively provided at outer circumferences of the punch and the counter punch. The upper and lower blank holders are respectively provided with a buffer mechanism. Friction material powders are sintered on both sides of the base sheet. The friction material layers are trimmed and planished by hot pressing. The base sheet with the friction material layers is fixed by the upper blank holder and the lower blank holder. A tooth profile with an absolute shear fractural surface is formed. The fixing indentation of the V-shaped structure of the friction material layers is cut off for obtaining a finished friction plate product with the friction material layers.