Abstract: Provided are compositions that include an isoamyl alcohol (IAA) sequestration agent, wherein the IAA sequestration agent includes an IAA binding moiety. In some embodiments, the IAA binding moiety is a nucleotide sequence or a peptide or polypeptide (e.g., and antibody or a fragment thereof that includes a paratope) to which IAA binds. In some embodiments, the composition further includes comprising a pharmaceutically acceptable carrier, excipient, or diluent, optionally a pharmaceutically acceptable carrier, excipient, or diluent that is pharmaceutically acceptable for use in a human. The presently disclosed subject matter also provides oligonucleotides, optionally further including a tag, and/or the oligonucleotide includes at least one modified base. Also provided are methods for using the same to reduce and/or delay cognitive decline associated with neurodegenerative disease and/or for sequestering isoamyl alcohol (IAA) produced by microbiota in the gut of subjects.

Abstract: Structural variants of 2D polymers and composites thereof are described.

Abstract: Compositions are provided that comprise a microvesicle derived from an edible plant. The microvesicles are coated with a plasma membrane derived from a targeting cell and can further be utilized to encapsulate a therapeutic agent. Methods for treating an inflammatory disorder and/or a cancer are further provided and include the step of administering to a subject an effective amount of a composition that includes a microvesicle coated with a plasma membrane derived from a targeting cell.

Abstract: The present disclosure is directed toward systems, methods, and non-transitory computer-readable media for determining for a folder a file organization score and providing a free flow element based on the file organization score selectable to transition from providing a folder view to providing a free flow view. In some embodiments, the disclosed systems determine the file organization score indicating file organizational patterns associated with content items within the folder. Furthermore, based on receiving an indication of a selection of the free flow element, the disclosed systems transition from providing the folder view of the folder to providing the free flow view depicting graphical representations of the content items. Moreover, the graphical representations of the content items are arranged according to one or more content features associated with the content items.

Abstract: This application provides a stiffener ring and a surface packaging assembly. The stiffener ring is configured to correct warpage of a substrate of the surface packaging assembly. The stiffener ring includes an annular stiffener ring body and an adjustment block that is disposed at a same layer as the stiffener ring body and that is fastened to at least one corner of the stiffener ring body. A coefficient of thermal expansion of the adjustment block is less than a coefficient of thermal expansion of the stiffener ring body. Coordination between the adjustment block and the stiffener ring body alleviates an “M-shape” overpressure phenomenon of a warpage deformation caused by the stiffener ring to the substrate at a high temperature, reduces warpage of the substrate, and improves flatness of the surface packaging assembly.

Abstract: The present disclosure provides an action camera, a selfie control method and apparatus, a movable platform, and a storage medium. The action camera includes: a camera body; a lens assembly, disposed on one side of the camera body; a first display apparatus, disposed on the same side as the lens assembly of the camera body, where the first display apparatus is configured to display an image obtained by the lens assembly; and a second display apparatus, disposed on another side of the camera body and opposite to the first display apparatus, where the second display apparatus is configured to obtain a touch operation, and generate a control command based on the touch operation to control, according to the control command, displaying performed by the first display apparatus. The action camera controls a front screen through “back-touch” by using a “rear screen”.

Abstract: The present invention relates to the field of biomedicine. Specifically, the present invention relates to an aptamer against DKK1 and uses thereof, in particular to uses in the treatment of DKK1-related diseases such as DKK1-related cancer.

Abstract: Embodiments of the present disclosure discloses a method, apparatus, a device, and a storage medium for message processing. The method includes: displaying a received predetermined message in a conversation interface; in response to determining that the current user triggers jumping to a detail interface of the predetermined message and returns to the conversation interface, determining whether a predetermined condition is satisfied; and in response to a determining result that the predetermined condition is satisfied, displaying, in the conversation interface, at least one shortcut operation control corresponding to the predetermined message.

Abstract: Embodiments of the present disclosure provide an interaction method and apparatus, an electronic device, a storage medium, and a computer program product. The method includes: presenting a multimedia player interface, and presenting a break reminder setting window on the multimedia player interface, where the break reminder setting window displays reminder setting options; and obtaining, in response to a setting confirmation in the break reminder setting window, a reminder triggering condition corresponding to a target reminder setting option selected in the break reminder setting window, and closing the break reminder setting window.

Abstract: The present disclosure provides an action camera, a selfie control method and apparatus, a movable platform, and a storage medium. The action camera includes: a camera body; a lens assembly, disposed on one side of the camera body; a first display apparatus, disposed on the same side as the lens assembly of the camera body, where the first display apparatus is configured to display an image obtained by the lens assembly; and a second display apparatus, disposed on another side of the camera body and opposite to the first display apparatus, where the second display apparatus is configured to obtain a touch operation, and generate a control command based on the touch operation to control, according to the control command, displaying performed by the first display apparatus. The action camera controls a front screen through “back-touch” by using a “rear screen”.

Abstract: Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.

Abstract: The invention relates to the field of biomedicine. In particular, the present invention relates to a nucleic acid molecule conjugate with extended in vivo half-life, wherein the nucleic acid molecule is conjugated to a fatty acid and a coumarin derivative. More specifically, the nucleic acid molecule is an aptamer, in particular an aptamer against sclerostin.

Abstract: The present disclosure is directed toward systems, methods, and non-transitory computer-readable media for determining for a folder a file organization score and providing a free flow element based on the file organization score selectable to transition from providing a folder view to providing a free flow view. In some embodiments, the disclosed systems determine the file organization score indicating file organizational patterns associated with content items within the folder. Furthermore, based on receiving an indication of a selection of the free flow element, the disclosed systems transition from providing the folder view of the folder to providing the free flow view depicting graphical representations of the content items. Moreover, the graphical representations of the content items are arranged according to one or more content features associated with the content items.

Abstract: The present disclosure provides a data processing method, apparatus and device and a storage medium.

Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: Crystalline NH4Be2BO3F2 or Be2BO3F (abbreviated as BBF) has nonlinear optical effect, is not deliquescent in the air, is chemically stable. They can be used in a variety of nonlinear optical fields and will pioneer the nonlinear optical applications in the deep UV band.

Abstract: Provided are a method for maintaining Walker constellation formation and a terminal device. The method comprises: determining a first offset amount of each satellite within a simulation time period according to parameters of a Walker constellation; performing first offset on each satellite according to the first offset amount to obtain a Walker constellation after the first offset; determining a second offset amount of each satellite within the simulation time period according to parameters of the Walker constellation after the first offset; and superimposing the first offset amount and the second offset amount, and performing second offset on each satellite so as to maintain the formation of the Walker constellation.

Abstract: A method of controlling a photographing device may include Obtaining setting operation from a user on a first touch screen or a second touch screen of a photographing device, the first touch screen being set on a lens side of the photographing device and a second touch screen being set on an opposite side of the lens side of the photographing device; displaying a first setting interface on the first touch screen and/or displaying a second setting interface on the second touch screen in accordance with the setting operation; and obtaining a setting parameter set by the user based on the first setting interface or the second setting interface, and applying the setting parameter to both the first touch screen and the second touch screen.

Abstract: Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.

Abstract: An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions that contain the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.