Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: Crystalline NH4Be2BO3F2 or Be2BO3F (abbreviated as BBF) has nonlinear optical effect, is not deliquescent in the air, is chemically stable. They can be used in a variety of nonlinear optical fields and will pioneer the nonlinear optical applications in the deep UV band.

Abstract: Provided are a method for maintaining Walker constellation formation and a terminal device. The method comprises: determining a first offset amount of each satellite within a simulation time period according to parameters of a Walker constellation; performing first offset on each satellite according to the first offset amount to obtain a Walker constellation after the first offset; determining a second offset amount of each satellite within the simulation time period according to parameters of the Walker constellation after the first offset; and superimposing the first offset amount and the second offset amount, and performing second offset on each satellite so as to maintain the formation of the Walker constellation.

Abstract: A method of controlling a photographing device may include Obtaining setting operation from a user on a first touch screen or a second touch screen of a photographing device, the first touch screen being set on a lens side of the photographing device and a second touch screen being set on an opposite side of the lens side of the photographing device; displaying a first setting interface on the first touch screen and/or displaying a second setting interface on the second touch screen in accordance with the setting operation; and obtaining a setting parameter set by the user based on the first setting interface or the second setting interface, and applying the setting parameter to both the first touch screen and the second touch screen.

Abstract: Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.

Abstract: An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions that contain the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.

Abstract: An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.

Abstract: The present disclosure provides a triggering method of an intervention prompt on the basis of user smoking behavior records, comprising: receiving smoking behavior record data associated with a user, wherein the smoking behavior record data includes a plurality of smoking behavior records; analyzing the smoking behavior record data to determine smoking behavior location data associated with each of the plurality of smoking behavior records; calculating a distance between locations indicated by every two smoking behavior location data; recording a first number of smoking behavior records in which the distance is less than a first distance as a set of smoking behavior record data; in a case where the first number is greater than a first threshold, determining a prompt range on the basis of the smoking behavior location data associated with the set of smoking behavior record data, wherein the prompt range includes consecutive areas or spaces that are connected and further includes locations indicated by the resp

Abstract: Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD11c dendritic cells, and preventing or reducing metastasis.

Abstract: Provided are methods for inhibiting immune responses against microbial antigens. In some embodiments, the methods include administering to the subject a composition containing a plurality of plant-derived exosome-like particles to inhibit immune esponses against microbial antigens. Also provided are methods for inhibiting development of septic shock in subjects, for inhibiting development of cytokine storm in subjects, and for inhibiting SARS-CoV-2-induced cytopathogenic effect. Also provided are compositions that include an exosome-derived nanoparticle comprising a first lipid bilayer and a second lipid bilayer coating the exosome-like nanoparticle and/or fused with the first lipid bilayer, wherein the second lipid bilayer comprises a targeting molecule, and methods for using the compositions to treat diseases, disorders, and conditions and/or to target a therapeutic agent to a cell, tissue, and/or organ of interest.

Abstract: Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (Nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. Pharmaceutical preparations including ginger-derived nanoparticles are further provided.

Abstract: The present disclosure relates to an optical proximity correction method and system. The correction method may include providing main patterns and setting a forbidden edge rule according to a spacing between adjacent main patterns. The method may further include adding an auxiliary pattern to a side portion of the main patterns. A quantity of auxiliary patterns added to side portions of the main patterns is obtained based on the forbidden edge rule. The forbidden edge rule defines whether an edge of the main patterns is a forbidden edge, and an auxiliary pattern is not added to a side portion of the forbidden edge.

Abstract: Compositions that include a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods for treating an inflammatory disorder and methods for treating a cancer are further provided and include administering an effective amount of a composition that includes a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.

Abstract: Microvesicle compositions and methods of use thereof are provided. The microvesicle composition includes a miRNA encapsulated by a microvesicle, wherein the microvesicle is derived from an edible plant. The method of use thereof includes treating a cancer in a subject by administering to the subject an effective amount of a microvesicle composition.

Abstract: This application provides a stiffener ring and a surface packaging assembly. The stiffener ring is configured to correct warpage of a substrate of the surface packaging assembly. The stiffener ring includes an annular stiffener ring body and an adjustment block that is disposed at a same layer as the stiffener ring body and that is fastened to at least one corner of the stiffener ring body. A coefficient of thermal expansion of the adjustment block is less than a coefficient of thermal expansion of the stiffener ring body. Coordination between the adjustment block and the stiffener ring body alleviates an “M-shape” overpressure phenomenon of a warpage deformation caused by the stiffener ring to the substrate at a high temperature, reduces warpage of the substrate, and improves flatness of the surface packaging assembly.

Abstract: An array substrate manufacturing method includes forming a plurality of first lead lines, a plurality of pixel electrodes, and a plurality of connecting lines over a substrate. Each first lead line is insulated from any pixel electrode, and each connecting line is insulated from any first lead line and is configured to electrically couple at least two pixel electrodes such that a set of pixel electrodes electrically coupled by each set of connecting lines substantially form an equivalent lead line. The method further includes detecting whether there is a short circuit between one equivalent lead line and a first lead line, and severing each of the plurality of connecting lines such that any two of the plurality of pixel electrodes are not electrically coupled.

Abstract: Disclosed is an optimal power flow acquiring method for regional distribution network of small hydropower groups based on deep learning, which specifically includes the following steps: generating required data sets by adopting continuous power flow and power flow equation calculation methods; the data set is randomly divided into training data (80 percent) and test data (20 percent); training the built convolutional neural network model with training data to learn the mapping relationship between load and generator output power; inputting test data, and directly obtaining PG and QG from the trained convolutional neural network; and solving residual variables Vi and ?i with traditional power flow solver. The application can accelerate the solving speed of the optimal power flow problem with higher prediction accuracy.

Abstract: An antenna structure and an electronic device using the antenna structure are disclosed. The antenna structure includes: a feed point; and a metal frame. The metal frame includes a body, a radiator and a coupling branch. The radiator and the coupling branch are connected to the body, and enclose, together with the body, a clearance area. A first end of the radiator away from the body and an end of the coupling branch away from the body form an antenna gap connected to the clearance area. The radiator is connected to the feed point and includes a through groove and an opening, the through groove runs along a height direction of the radiator, and the opening is connected to the through groove along a thickness direction of the radiator. A junction of the feed point and the radiator and the opening are located at both sides of the through groove.

Abstract: An antenna structure and an electronic device using the antenna structure are disclosed. The antenna structure includes: a feed point; and a metal frame. The metal frame includes a body, a radiator and a coupling branch. The radiator and the coupling branch are connected to the body, and enclose, together with the body, a clearance area. A first end of the radiator away from the body and an end of the coupling branch away from the body form an antenna gap connected to the clearance area. The radiator is connected to the feed point and includes a through groove and an opening, the through groove runs along a height direction of the radiator, and the opening is connected to the through groove along a thickness direction of the radiator. A junction of the feed point and the radiator and the opening are located at both sides of the through groove.

Abstract: Provided are methods for increasing insulin sensitivity in subjects. In some embodiments, the method include administering to the subject an effective amount of a composition comprising a lipid bilayer, wherein the lipid bilayer is low in total phosphatidylcholine (PC) or has been treated to reduce total PC.