Abstract: An exosomal composition is provided that includes a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.

Abstract: The present disclosure provides a triggering method of an intervention prompt on the basis of user smoking behavior records, comprising: receiving smoking behavior record data associated with a user, wherein the smoking behavior record data includes a plurality of smoking behavior records; analyzing the smoking behavior record data to determine smoking behavior location data associated with each of the plurality of smoking behavior records; calculating a distance between locations indicated by every two smoking behavior location data; recording a first number of smoking behavior records in which the distance is less than a first distance as a set of smoking behavior record data; in a case where the first number is greater than a first threshold, determining a prompt range on the basis of the smoking behavior location data associated with the set of smoking behavior record data, wherein the prompt range includes consecutive areas or spaces that are connected and further includes locations indicated by the resp

Abstract: Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD11c dendritic cells, and preventing or reducing metastasis.

Abstract: Provided are methods for inhibiting immune responses against microbial antigens. In some embodiments, the methods include administering to the subject a composition containing a plurality of plant-derived exosome-like particles to inhibit immune esponses against microbial antigens. Also provided are methods for inhibiting development of septic shock in subjects, for inhibiting development of cytokine storm in subjects, and for inhibiting SARS-CoV-2-induced cytopathogenic effect. Also provided are compositions that include an exosome-derived nanoparticle comprising a first lipid bilayer and a second lipid bilayer coating the exosome-like nanoparticle and/or fused with the first lipid bilayer, wherein the second lipid bilayer comprises a targeting molecule, and methods for using the compositions to treat diseases, disorders, and conditions and/or to target a therapeutic agent to a cell, tissue, and/or organ of interest.

Abstract: Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (Nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. Pharmaceutical preparations including ginger-derived nanoparticles are further provided.

Abstract: The present disclosure relates to an optical proximity correction method and system. The correction method may include providing main patterns and setting a forbidden edge rule according to a spacing between adjacent main patterns. The method may further include adding an auxiliary pattern to a side portion of the main patterns. A quantity of auxiliary patterns added to side portions of the main patterns is obtained based on the forbidden edge rule. The forbidden edge rule defines whether an edge of the main patterns is a forbidden edge, and an auxiliary pattern is not added to a side portion of the forbidden edge.

Abstract: Compositions that include a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods for treating an inflammatory disorder and methods for treating a cancer are further provided and include administering an effective amount of a composition that includes a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.

Abstract: Microvesicle compositions and methods of use thereof are provided. The microvesicle composition includes a miRNA encapsulated by a microvesicle, wherein the microvesicle is derived from an edible plant. The method of use thereof includes treating a cancer in a subject by administering to the subject an effective amount of a microvesicle composition.

Abstract: This application provides a stiffener ring and a surface packaging assembly. The stiffener ring is configured to correct warpage of a substrate of the surface packaging assembly. The stiffener ring includes an annular stiffener ring body and an adjustment block that is disposed at a same layer as the stiffener ring body and that is fastened to at least one corner of the stiffener ring body. A coefficient of thermal expansion of the adjustment block is less than a coefficient of thermal expansion of the stiffener ring body. Coordination between the adjustment block and the stiffener ring body alleviates an “M-shape” overpressure phenomenon of a warpage deformation caused by the stiffener ring to the substrate at a high temperature, reduces warpage of the substrate, and improves flatness of the surface packaging assembly.

Abstract: An array substrate manufacturing method includes forming a plurality of first lead lines, a plurality of pixel electrodes, and a plurality of connecting lines over a substrate. Each first lead line is insulated from any pixel electrode, and each connecting line is insulated from any first lead line and is configured to electrically couple at least two pixel electrodes such that a set of pixel electrodes electrically coupled by each set of connecting lines substantially form an equivalent lead line. The method further includes detecting whether there is a short circuit between one equivalent lead line and a first lead line, and severing each of the plurality of connecting lines such that any two of the plurality of pixel electrodes are not electrically coupled.

Abstract: Disclosed is an optimal power flow acquiring method for regional distribution network of small hydropower groups based on deep learning, which specifically includes the following steps: generating required data sets by adopting continuous power flow and power flow equation calculation methods; the data set is randomly divided into training data (80 percent) and test data (20 percent); training the built convolutional neural network model with training data to learn the mapping relationship between load and generator output power; inputting test data, and directly obtaining PG and QG from the trained convolutional neural network; and solving residual variables Vi and ?i with traditional power flow solver. The application can accelerate the solving speed of the optimal power flow problem with higher prediction accuracy.

Abstract: An antenna structure and an electronic device using the antenna structure are disclosed. The antenna structure includes: a feed point; and a metal frame. The metal frame includes a body, a radiator and a coupling branch. The radiator and the coupling branch are connected to the body, and enclose, together with the body, a clearance area. A first end of the radiator away from the body and an end of the coupling branch away from the body form an antenna gap connected to the clearance area. The radiator is connected to the feed point and includes a through groove and an opening, the through groove runs along a height direction of the radiator, and the opening is connected to the through groove along a thickness direction of the radiator. A junction of the feed point and the radiator and the opening are located at both sides of the through groove.

Abstract: An antenna structure and an electronic device using the antenna structure are disclosed. The antenna structure includes: a feed point; and a metal frame. The metal frame includes a body, a radiator and a coupling branch. The radiator and the coupling branch are connected to the body, and enclose, together with the body, a clearance area. A first end of the radiator away from the body and an end of the coupling branch away from the body form an antenna gap connected to the clearance area. The radiator is connected to the feed point and includes a through groove and an opening, the through groove runs along a height direction of the radiator, and the opening is connected to the through groove along a thickness direction of the radiator. A junction of the feed point and the radiator and the opening are located at both sides of the through groove.

Abstract: Provided are methods for increasing insulin sensitivity in subjects. In some embodiments, the method include administering to the subject an effective amount of a composition comprising a lipid bilayer, wherein the lipid bilayer is low in total phosphatidylcholine (PC) or has been treated to reduce total PC.

Abstract: Provided are methods for preventing and/or treating oral diseases, disorders, and/or conditions. In some embodiments, the methods relate to administering to the oral cavity of a subject in need thereof a composition that includes an effective amount of ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof. Also provided are methods for preventing and/or treating periodontitis, methods for reducing growth of and/or pathogenicity of microorganisms in the oral cavities of subjects, methods for reducing microorganismal motility, and methods for reducing bone loss in the oral cavities of subjects associated with infection with microorganisms. Also provided are compositions that can be employed in the disclosed methods.

Abstract: The present disclosure provides an action camera, a selfie control method and apparatus, a movable platform, and a storage medium. The action camera includes: a camera body; a lens assembly, disposed on one side of the camera body; a first display apparatus, disposed on the same side as the lens assembly of the camera body, where the first display apparatus is configured to display an image obtained by the lens assembly; and a second display apparatus, disposed on another side of the camera body and opposite to the first display apparatus, where the second display apparatus is configured to obtain a touch operation, and generate a control command based on the touch operation to control, according to the control command, displaying performed by the first display apparatus. The action camera controls a front screen through “back-touch” by using a “rear screen”.

Abstract: The disclosure provides a reaction kettle, a polypeptide synthesis cleavage system and their use in polypeptide synthesis or cleavage. The reaction kettle comprises: (1) a kettle body; (2) a stirring device located at the upper part of the kettle body and extending to the interior of the kettle body; (3) a liquid feed port, a solid feed port, an inert gas inlet and an inert gas outlet located at the upper part of the kettle body; (4) a liquid discharge port and a liquid guiding groove at the bottom of the kettle body, wherein the liquid discharge port is located at the lowest point of the liquid guiding groove; (5) a filtering device located above the liquid guiding groove; (6) a solid discharge portpassing through the bottom of the kettle body and the filtering device; and (7) a discharge valve configured at the solid discharge port.

Abstract: A method of treating a subject suffering from mental disorder including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A method of treating a subject suffering from pain associated with nerve injury including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A pharmaceutical composition including the cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof as active ingredient, one or more antidepressant compounds, and a pharmaceutically acceptable excipient.

Abstract: Provided are a method for maintaining Walker constellation formation and a terminal device. The method comprises: determining a first offset amount of each satellite within a simulation time period according to parameters of a Walker constellation; performing first offset on each satellite according to the first offset amount to obtain a Walker constellation after the first offset; determining a second offset amount of each satellite within the simulation time period according to parameters of the Walker constellation after the first offset; and superimposing the first offset amount and the second offset amount, and performing second offset on each satellite so as to maintain the formation of the Walker constellation.

Abstract: A display substrate includes: a base substrate including a photosensitive region, the photosensitive region including a plurality of display regions spaced apart and a gap region between the plurality of display regions; a first electrode layer on the base substrate; a light-emitting layer on a side of the first electrode layer away from the base substrate; and a second electrode layer on a side of the light-emitting layer away from the base substrate. Each display region corresponds to at least one first luminescent material region of the light-emitting layer; the gap region corresponds to the plurality of second luminescent material regions of the light-emitting layer; a part of the second electrode layer in the photosensitive region includes a plurality of second electrodes spaced apart, and an orthographic projection of each second electrode on the base substrate overlaps with each display region.