Abstract: A display substrate includes: a base substrate including a photosensitive region, the photosensitive region including a plurality of display regions spaced apart and a gap region between the plurality of display regions; a first electrode layer on the base substrate; a light-emitting layer on a side of the first electrode layer away from the base substrate; and a second electrode layer on a side of the light-emitting layer away from the base substrate. Each display region corresponds to at least one first luminescent material region of the light-emitting layer; the gap region corresponds to the plurality of second luminescent material regions of the light-emitting layer; a part of the second electrode layer in the photosensitive region includes a plurality of second electrodes spaced apart, and an orthographic projection of each second electrode on the base substrate overlaps with each display region.

Abstract: The present disclosure provides a multi-antenna system comprising at least two antenna units and a neutralization line for connecting two adjacent antenna units, and the neutralization line is provided with an inductor element. The invention also provides a mobile terminal. The multi-antenna system and the mobile terminal provided by the present disclosure could significantly increase the isolation degree between the antenna units by providing a neutralization line between the two adjacent antenna units for connecting the same and providing an inductor element on the neutralization line, thereby reducing the mutual coupling interference between antenna units and improving the antenna performance.

Abstract: An array substrate manufacturing method includes forming a plurality of first lead lines, a plurality of pixel electrodes, and a plurality of connecting lines over a substrate. Each first lead line is insulated from any pixel electrode, and each connecting line is insulated from any first lead line and is configured to electrically couple at least two pixel electrodes such that a set of pixel electrodes electrically coupled by each set of connecting lines substantially form an equivalent lead line. The method further includes detecting whether there is a short circuit between one equivalent lead line and a first lead line, and severing each of the plurality of connecting lines such that any two of the plurality of pixel electrodes are not electrically coupled.

Abstract: Provided are compositions and methods for using the same. In some embodiments, the compositions include an EPELN encapsulating and/or having associated therewith an active agent and a plasma membrane derived from a tumor and/or cancer cell coating the EPELN. In some embodiments, the active agent is a therapeutic agent or an immune response modifier, and in some embodiments the plasma membrane has one or more tumor-associated and/or cancer-associated antigens. Also provided are methods for using the compositions for treating tumors and/or cancers, inducing anti-tumor and/or anti-cancer immune responses, activating antigen-presenting cells, targeting CD1 lc dendritic cells, and preventing or reducing metastasis.

Abstract: The invention relates to the field of biomedicine. Specifically, the present invention relates to aptamers against sclerostin and uses thereof, especially uses in the treatment of sclerostin-related diseases such as osteoporosis.

Abstract: Provided are methods for modulating gut microbiota in subjects. In some embodiments, the methods include administering to a subject an effective amount of a composition that includes a first edible plant-derived nanoparticle encapsulating an effective amount of RNA. Also provided are methods for preventing and/or treating gut dysbiosis, methods for modulating bacterial growth, methods for modulating inflammatory cytokines, methods for reducing migration of bacterial from the gut to gut-associated bloodstream, and compositions for use in the presently disclosed methods, including pharmaceutical compositions.

Abstract: Crystalline NH4Be2BO3F2 or Be2BO3F (abbreviated as BBF) has nonlinear optical effect, is not deliquescent in the air, is chemically stable. They can be used in a variety of nonlinear optical fields and will pioneer the nonlinear optical applications in the deep UV band.

Abstract: The present disclosure relates to a display panel, a display device, and a driving method for the display device, and relates to the field of display technology. The display panel includes a display area having a plurality of pixels, each of the pixels including a plurality of sub-pixels; and the display area is at least divided into a first area and a second area, the pixel density of the first area is smaller than the pixel density of the second area, and the number of sub-pixels in each of the pixels of the first area is larger than the number of sub-pixels in each of the pixels of the second area. The display panel according to the present disclosure may achieve a full-screen display, and avoid a hole or holes for mounting the camera module on the display panel.

Abstract: Provided are methods for treating tumors and/or cancers. In some embodiments, the methods relate to administering to a subject in need thereof an effective amount of a nanoparticle derived from an edible plant and an effective amount of an autologous exosome. Also provided are methods for enhancing accumulation of nanoparticles in the lungs of subjects, methods for delivering agents to the liver, brain, and/or bones of subjects, and methods for delivering agents across the blood-brain barrier of subjects.

Abstract: Crystalline NH4Be2BO3F2 or Be2BO3F (abbreviated as BBF) has nonlinear optical effect, is not deliquescent in the air, is chemically stable. They can be used in a variety of nonlinear optical fields and will pioneer the nonlinear optical applications in the deep UV band.

Abstract: A method of treating a subject suffering from mental disorder including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A method of treating a subject suffering from pain associated with nerve injury including the step of administering an effective amount of a cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof to the subject. A pharmaceutical composition including the cholecystokinin-2 receptor antagonist or a pharmaceutical acceptable salt thereof as active ingredient, one or more antidepressant compounds, and a pharmaceutically acceptable excipient.

Abstract: Methods for diagnosis or prognosis of a cancer in a subject include isolating one or more nanovesicles from a biological sample obtained from the subject, determining the amount in the biological sample of the one or more nanovesicles, and comparing the amount of the one or more nanovesicles to a control level to thereby diagnose the cancer. The one or more nanovesicles are obtained by depleting the biological sample of exosomes prior to the isolation of the nanovesicles. Methods for identifying a tumor metastasis in a subject are also provided and include fractionating a biological sample from a subject to obtain a fraction including one or more exosomes and one or more nanovesicles having a diameter of about 8-12 nm, and then isolating the one or more nanovesicles to diagnose the tumor metastasis.

Abstract: An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.

Abstract: Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (Nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. Pharmaceutical preparations including ginger-derived nanoparticles are further provided.

Abstract: Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.

Abstract: A display substrate, a fabricating method thereof and a display device are disclosed. The display substrate includes: a base substrate including a photosensitive region, the photosensitive region including a plurality of display regions spaced apart and a gap region between the plurality of display regions; a first electrode layer on the base substrate; a light-emitting layer on a side of the first electrode layer away from the base substrate; and a second electrode layer on a side of the light-emitting layer away from the base substrate.

Abstract: Methods for diagnosing a cancer in a subject are provided in which a biological sample is provided from a subject including one or more exosomes. The exosomes are isolated from the biological sample and are used to identify a type and/or amount of one or more tumor suppressor miRNAs encapsulated by the exosomes. A measurable difference in the type and/or amount of the tumor suppressor miRNAs as compared to control levels allows for a diagnosis of cancer in the subject. Methods of selecting or modifying a treatment and methods for determining whether to initiate or continue prophylaxis or treatment for a cancer based on the exosomal miRNAs is further provided.

Abstract: Methods for treating intestinal inflammation and/or colon cancer include administering an amount of a broccoli-derived nanoparticle to a subject in need thereof. Pharmaceutical compositions comprising broccoli-derived nanoparticles are also provided. Further provided are methods for screening for a compound useful for treating a colon cancer that include the steps of contacting a provided intestinal epithelial cell with a test compound and measuring an amount of expression of COP9 signalsome subunit 8 (CSN8) in the intestinal epithelial cell to thereby identify the test compound as useful for treating colon cancer.

Abstract: The present disclosure provides a multi-antenna system comprising at least two antenna units and a neutralization line for connecting two adjacent antenna units, and the neutralization line is provided with an inductor element. The invention also provides a mobile terminal. The multi-antenna system and the mobile terminal provided by the present disclosure could significantly increase the isolation degree between the antenna units by providing a neutralization line between the two adjacent antenna units for connecting the same and providing an inductor element on the neutralization line, thereby reducing the mutual coupling interference between antenna units and improving the antenna performance.

Abstract: The present invention relates to a cell culture support including a substrate and a thermoresponsive polymeric blend layer, wherein the polymeric blend layer includes at least one thermoresponsive polymer and at least one network forming adhesion promoter. The present invention further relates a method of making a cell culture complex including: providing a substrate; blending at least one thermoresponsive polymer and at least one network forming adhesion promoter to provide a polymeric blend; applying a thin film of said polymeric blend to the substrate to provide a polymeric blend layer on the substrate; curing the polymeric blend layer on the substrate to provide a cell culture support; and depositing cells onto said cell culture support, wherein the cells may optionally further include medium, to provide a cell culture complex.