Abstract: Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R1-R7, G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.

Abstract: Provided are a small interfering nucleic acid against bone formation inhibiting gene CKIP-1, a pharmaceutical composition thereof, and uses thereof in preparation of a pharmaceutical composition for treating and/or preventing diseases related to the abnormal expression of CKIP-1 gene. The small interfering nucleic acid is capable of cross-species inhibiting the CKIP-1 gene expression, inhibiting CKIP-1 expression in human, rhesus, rats and mice simultaneously, and facilitating the differentiation of osteoblasts and mineralization of bone matrix effectively.

Abstract: A composition is provided that includes a microvesicle derived from an edible plant and a therapeutic agent conjugated to the microvesicle. The therapeutic agent can be chemically-linked to a plasma membrane of the microvesicle with a cross-linking agent and the edible plant can be a fruit or a vegetable. Methods for treating an inflammatory disorder or a cancer are further provided and include administering to a subject in need thereof an effective amount of a composition including a microvesicle derived from an edible plant and having a therapeutic agent conjugated to the microvesicle.

Abstract: A blow molding device for a rotary bottle blowing machine includes: a support base including a power-input shaft and a mold-insert control shaft which are pivotally disposed on the support base and extend along an axial direction; a drive source for driving the power-input shaft and the mold-insert control shaft to rotate; and a mold assembly with a first and second movable mold inserts pivotally disposed on the support base. The mold assembly makes the first and second movable mold inserts pivot toward or away from each other, rotation of the power-input shaft makes a bottom mold unit move in the axial direction, and can lock the first and second movable mold inserts. A method for using the blow molding device includes steps of mold opening or closing, mold lifting, and mold locking, and these steps are performed by using a single drive source.

Abstract: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.

Abstract: A computer implemented method and telecommunications diagnostic apparatus that correlates packets on a core network with those on the access network. Generated is an identification attribute from Information Elements (IEs) in S1AP packets present in the core network and accessible to the access network. The generated identification attribute is integrated to an access and core session of the access and core network to correlate data packets between the access and core session by comparing if a core session contains the same identification attribute as that of an access session within the life span of the access session.

Abstract: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.

Abstract: Compositions comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle are provided. Methods of treating an inflammatory disorder and methods of treating a cancer are further provided and include administering an effective amount of a composition comprising a therapeutic agent encapsulated by an edible plant-derived microvesicle to a subject. Further provided are methods of diagnosing a colon cancer that include the steps of administering an edible plant-derived microvesicle incorporating a detectable label to a subject and then determining an amount of the detectable label in an intestine of the subject.

Abstract: The present invention relates to a cell culture support comprising a substrate and a thermoresponsive polymeric blend layer, wherein the polymeric blend layer comprises at least one thermoresponsive polymer and at least one network forming adhesion promoter. The present invention further relates a method of making a cell culture complex comprising: providing a substrate; blending at least one thermoresponsive polymer and at least one network forming adhesion promoter to provide a polymeric blend; applying a thin film of said polymeric blend to the substrate to provide a polymeric blend layer on the substrate; curing the polymeric blend layer on the substrate to provide a cell culture support; and depositing cells onto said cell culture support, wherein the cells may optionally further comprise medium, to provide a cell culture complex.

Abstract: An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.

Abstract: An LED substrate may comprise a base including a first surface and a second surface; and a conductive structure formed on at least a part of the first surface and at least a part of the second surface, the part of the conductive structure formed on the first surface electrically connected to the part of the conductive structure formed on the second surface. A method for forming an LED substrate, a method for forming an LED chip, and an LED chip manufactured therefrom may be provided as well.

Abstract: A multi-core processor and a frequency conversion device thereof as well as a method of communication between the cores are disclosed. Each processor core of the multi-core processor includes a frequency conversion device, which includes a multi-bit state changing means, a multiple selector, a frequency conversion coefficient register, a multi-input OR gate and a clock-gating circuit unit. A common original clock is sent to the frequency conversion device of each processor core at work. The frequency conversion device real-timely reads the value of the frequency conversion coefficient register of a corresponding processor core and receives data transmission valid signals from other processor cores. By gating the common original clock, a frequency conversion function of the processor core is completed.

Abstract: An antenna testing device includes an analyzer, a transmission probe electrically connected to the analyzer, a receiving probe electrically connected to the analyzer, and a shielded box having a cutoff frequency. The analyzer generates a test signal the frequency of which is lower than the cutoff frequency, the transmission probe receive the test signal and sends the test signal to the shielded box. The antenna is coupled with the transmission probe and generates a coupled signal, the receiving probe receives the coupled signal and sends the coupled signal to the analyzer. The analyzer analyzes the coupled signal and the test signal, the analyzer calculates the return loss of the antenna.

Abstract: An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a Stat3 inhibitor. Pharmaceutical compositions comprising the exosomal compositions are also provided. Methods for treating an inflammatory disease or a cancer are further provided and include administering an effective amount of an exosomal composition to a subject in need thereof to thereby treat the inflammatory disorder or the cancer.

Abstract: An electronic device includes at least a pair of opposite touch keys defined on a touch panel, a touch sensing unit, a storage unit, a touch control unit, and a CPU. The storage unit stores a key-coordinate area relation list, which defines a relationship between the keys and the coordinate areas. A touch sensing unit included in the touch control unit generates signals in response to user touches on the keys. A touch area determining module included determines the coordinates touched according to the signals, and searching the key-coordinate area relation list to determine the coordinate areas including touched coordinates, and determines whether the touched coordinates distributed in both of the coordinate areas corresponding to the one pair of the pair of opposite touch keys. Then the key determining module determines an “OK” key is touched if yes. The CPU executes a function corresponding. A related method is also provided.

Abstract: A hole-jetting type mixer-reactor, comprises the following parts: a first feeding port, a second feeding port, an outer casing, an inner casing, jet holes and a mixing reaction zone. The inner casing is inside the outer casing, and the lower portion of the outer casing forms a buffer chamber with the inner casing. The first feeding port connects with the inner casing to constitute one flow channel, and the second feeding port connects with the buffer chamber to form the other flow channel. The jet holes are on the wall of the inner casing situated at lower portion of the buffer chamber. The mixing reaction zone is inside the inner casing below the jet holes. The cross section of the inner casing is rectangular or rectangle-like. The mixer-reactor can achieve a fast mixing of two reactant streams which reacts with instantaneous, complicated parallel or consecutive competing reactions. The time scale of the mixing process is several milliseconds.

Abstract: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.

Abstract: An antenna testing device includes an analyzer, a transmission probe electrically connected to the analyzer, a receiving probe electrically connected to the analyzer, and a shielded box having a cutoff frequency. The analyzer generates a test signal the frequency of which is lower than the cutoff frequency, the transmission probe receive the test signal and sends the test signal to the shielded box. The antenna is coupled with the transmission probe and generates a coupled signal, the receiving probe receives the coupled signal and sends the coupled signal to the analyzer. The analyzer analyzes the coupled signal and the test signal, the analyzer calculates the return loss of the antenna.

Abstract: Computer system for controlled creation, processing, administration and display of quality information within an enterprise. Linkages may be defined among enterprise entities, process/product development attributes, strategies, goals, process improvement opportunities, etc. Visual analysis of data associated with the linkages is provided in an interactive fashion. Linkages may also be defined among online quality-related documentation throughout an enterprise such that information is automatically propagated/reconciled through the enterprise in a controlled and efficient fashion. The creation of process documentation for new products is facilitated based on a concept of content/document inheritance.

Abstract: A multi-core processor and a frequency conversion device thereof as well as a method of communication between the cores are disclosed. Each processor core of the multi-core processor includes a frequency conversion device, which includes a multi-bit state changing means, a multiple selector, a frequency conversion coefficient register, a multi-input OR gate and a clock-gating circuit unit. A common original clock is sent to the frequency conversion device of each processor core at work. The frequency conversion device real-timely reads the value of the frequency conversion coefficient register of a corresponding processor core and receives data transmission valid signals from other processor cores. By gating the common original clock, a frequency conversion function of the processor core is completed.