Patents by Inventor George Kemble

George Kemble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi plasmid system for the production of influenza virus
    Patent number: 9255253
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: February 9, 2016
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory Duke
  • Multi plasmid system for the production of influenza virus
    Patent number: 9238825
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: January 19, 2016
    Assignee: MedImmune, LLC
    Inventors: Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 9028838
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: May 12, 2015
    Assignee: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8877210
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: November 4, 2014
    Assignee: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20140242102
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: January 15, 2014
    Publication date: August 28, 2014
    Applicant: MEDIMMUNE, LLC
    Inventors: Chin-Fen YANG, George KEMBLE, Chongguang LIU
  • MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
    Publication number: 20140220075
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
    Type: Application
    Filed: March 21, 2014
    Publication date: August 7, 2014
    Applicant: MEDIMMUNE, LLC
    Inventors: Enrich HOFFMAN, Hong Jin, Bin Lu, Greg Duke, George Kemble
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8765136
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: July 1, 2014
    Assignee: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Kanta Subbarao, Brian Murphy
  • Methods and compositions for expressing negative-sense viral RNA in canine cells
    Patent number: 8742089
    Abstract: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: June 3, 2014
    Assignee: MedImmune, LLC
    Inventors: Gregory Duke, George Kemble, James Young, Zhaoti Wang
  • MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
    Publication number: 20140134208
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Application
    Filed: September 26, 2013
    Publication date: May 15, 2014
    Applicant: MEDIMMUNE, LLC
    Inventors: Erich HOFFMANN, Hong JIN, George KEMBLE, Zhongying CHEN
  • Multi plasmid system for the production of influenza virus
    Patent number: 8722059
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: May 13, 2014
    Assignee: MedImmune, LLC
    Inventors: Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble
  • REFRIGERATOR-TEMPERATURE STABLE INFLUENZA VACCINE COMPOSITIONS
    Publication number: 20140127262
    Abstract: Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 8, 2014
    Applicant: MEDIMMUNE, LLC
    Inventors: George KEMBLE, George Robert TRAGER, Richard SCHWARTZ
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8691239
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: April 8, 2014
    Assignee: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8685410
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: April 1, 2014
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Refrigerator-temperature stable influenza vaccine compositions
    Patent number: 8652822
    Abstract: Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: February 18, 2014
    Assignee: Medimmune, LLC
    Inventors: George Kemble, George Robert Trager, Richard Schwartz
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20140023680
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: MEDIMMUNE, LLC
    Inventors: Chin-Fen YANG, George KEMBLE, Chongguang LIU
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8591914
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: November 26, 2013
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8580277
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: November 12, 2013
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Kanta Subbaro, Brian Murphy
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8574593
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: November 5, 2013
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Multi plasmid system for the production of influenza virus
    Patent number: 8574591
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: November 5, 2013
    Assignee: Medimmune, LLC
    Inventors: Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20130243816
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: February 14, 2013
    Publication date: September 19, 2013
    Applicant: MEDIMMUNE, LLC
    Inventors: Chin-Fen YANG, George Kemble, Chongguang Liu