Patents by Inventor George Kemble

George Kemble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Refrigerator-temperature stable influenza vaccine compositions
    Publication number: 20060110406
    Abstract: Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
    Type: Application
    Filed: October 4, 2005
    Publication date: May 25, 2006
    Applicant: MEDIMMUNE VACCINES, INC.
    Inventors: George Kemble, George Trager, Richard Schwartz
  • Influenza hemagglutinin and neuraminidase variants
    Publication number: 20060008473
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: May 20, 2005
    Publication date: January 12, 2006
    Inventors: Chin-Fen Yang, George Kemble, Kanta Subbarao, Brian Murphy
  • Influenza hemagglutinin and neuraminidase variants
    Publication number: 20050287172
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 29, 2005
    Inventors: Chin-Fen Yang, George Kemble
  • Multi plasmid system for the production of influenza virus
    Publication number: 20050266026
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 1, 2005
    Inventors: Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • Multi plasmid system for the production of influenza virus
    Publication number: 20050158342
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 21, 2005
    Applicant: MEDIMMUNE, INC.
    Inventors: George Kemble, Gregory Duke
  • Methods and compositions for treatment and prevention of HSV-2 infections and conditions
    Publication number: 20050112142
    Abstract: Live, attenuated, phenotypically stable HSV-2 viruses and methods of making and using the virus are provided. Live, attenuated HSV-2 viruses are constructed using recombinant techniques and can be used in a pharmaceutical composition for prophylactic treatment of HSV-2 infections and for treatment of recurrent HSV-2 related diseases and conditions.
    Type: Application
    Filed: April 23, 2004
    Publication date: May 26, 2005
    Inventors: Richard Spaete, George Kemble, Bernard Roizman, Mark Prichard
  • Influenza hemagglutinin and neuraminidase variants
    Publication number: 20050042229
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: June 16, 2004
    Publication date: February 24, 2005
    Applicant: MedImmune Vaccines, Inc.
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Methods of producing influenza vaccine compositions
    Publication number: 20040265987
    Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
    Type: Application
    Filed: February 25, 2004
    Publication date: December 30, 2004
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Robert Trager, George Kemble, Richard M. Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred A. Pan, Eric Tsao, Chiaoyin Kathy Wang, Luisa Yee, Palani Balu
  • Multi plasmid system for the production of influenza virus
    Publication number: 20040029251
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: February 12, 2004
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble