Patents by Inventor George Kemble

George Kemble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Influenza Hemagglutinin And Neuraminidase Variants
    Publication number: 20090175898
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: October 31, 2008
    Publication date: July 9, 2009
    Applicant: Medlmmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Multi Plasmid System For The Production Of Influenza Virus
    Publication number: 20090175907
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Application
    Filed: October 20, 2008
    Publication date: July 9, 2009
    Applicant: MedImmune, LLC
    Inventors: Erich Hoffman, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • Influenza Hemagglutinin And Neuraminidase Variants
    Publication number: 20090175909
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: March 6, 2009
    Publication date: July 9, 2009
    Applicant: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble
  • Attenuation of cytomegalovirus virulence
    Patent number: 7550149
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: June 23, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Influenza Hemagglutinin and Neuraminidase Variants
    Publication number: 20090136530
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 28, 2009
    Applicants: MedImmune, LLC, Government of The United States of America As Represented By the Secretary Of The Department Of
    Inventors: Chin-Fen Yang, George Kemble, Kanta Subbarao, Brian Murphy
  • Attenuation of cytomegalovirus virulence
    Patent number: 7537770
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: May 26, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 7527800
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: May 5, 2009
    Assignee: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 7504109
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: March 17, 2009
    Assignees: MedImmune, LLC, The United States of America as Represented by The Department of Health Services, National Institute of Health
    Inventors: Chin-Fen Yang, George Kemble, Kanta Subbarao, Brian Murphy
  • Multi plasmid system for the production of influenza virus
    Patent number: 7465456
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: December 16, 2008
    Assignee: MedImmune, LLC
    Inventors: Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 7459162
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: December 2, 2008
    Assignee: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Influenza Hemagglutinin And Neuraminidase Variants
    Publication number: 20080069821
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: August 9, 2007
    Publication date: March 20, 2008
    Applicants: MedImmune Vaccines, Inc., The Government of the United States of America National Institutes of Health
    Inventors: Chin-Fen Yang, George Kemble, Kanta Subbarao, Brian Murphy
  • Influenza Hemagglutinin And Neuraminidase Variants
    Publication number: 20080057081
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: August 9, 2007
    Publication date: March 6, 2008
    Applicant: MedImmune Vaccines, Inc.
    Inventors: Chin-Fen Yang, George Kemble
  • Recombinant Human Cytomegalovirus And Vaccines Comprising Heterologous Antigens
    Publication number: 20080044384
    Abstract: The present invention relates to recombinant HCMV (human cytomegalovirus) expressing a pp65 polypeptide or fragment thereof fused to a heterologous or non-native polypeptide, in particular immunogenic and/or antigenic polypeptides. In particular, the heterologous gene products include antigenic or immunogenic polypeptides from a variety of pathogens, cellular genes, tumor antigens, and viruses. The recombinant viruses may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
    Type: Application
    Filed: June 24, 2005
    Publication date: February 21, 2008
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Kemble, Harry Greenberg, Gregory Duke
  • Attenuation of Cytomegalovirus Virulence
    Publication number: 20080019945
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Application
    Filed: December 20, 2006
    Publication date: January 24, 2008
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • ATTENUATION OF CYTOMEGALOVIRUS VIRULENCE
    Publication number: 20070292455
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Application
    Filed: December 21, 2006
    Publication date: December 20, 2007
    Applicant: MedImmune Vaccines, Inc.
    Inventors: George Kemble, Gregory Duke, Richard Spaete
  • Methods of Producing Influenza Vaccine Compositions
    Publication number: 20070161085
    Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
    Type: Application
    Filed: January 30, 2007
    Publication date: July 12, 2007
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Trager, George Kemble, Richard Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred Pan, Eric Tsao, Chiaoyin Wang, Luisa Yee, Palani Balu
  • Attenuation of cytomegalovirus virulence
    Patent number: 7204990
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 17, 2007
    Assignee: MedImmune Vaccines, Inc.
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Methods and compositions for expressing negative-sense viral RNA in canine cells
    Publication number: 20070031941
    Abstract: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.
    Type: Application
    Filed: August 9, 2006
    Publication date: February 8, 2007
    Applicant: MEDIMMUNE VACCINES, INC.
    Inventors: Gregory Duke, George Kemble, James Young, Zhaoti Wang
  • Methods and compositions for expressing negative-sense viral RNA in canine cells
    Publication number: 20060286591
    Abstract: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.
    Type: Application
    Filed: June 20, 2006
    Publication date: December 21, 2006
    Applicant: MEDIMMUNE VACCINES, INC.
    Inventors: Gregory Duke, George Kemble, James Young, Zhaoti Wang
  • Influenza hemagglutinin and neuraminidase variants
    Publication number: 20060252132
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: March 6, 2006
    Publication date: November 9, 2006
    Applicant: MEDIMMUNE VACCINES, INC.
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu