Patents by Inventor George Kemble

George Kemble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8431137
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: April 30, 2013
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble
  • Multi plasmids system for the production of influenza virus
    Patent number: 8409843
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: April 2, 2013
    Assignee: Medimmune, LLC
    Inventors: George Kemble, Gregory Duke
  • Reassortant influenza B viruses
    Patent number: 8404248
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: March 26, 2013
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE-SENSE VIRAL RNA IN CANINE CELLS
    Publication number: 20120329150
    Abstract: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 27, 2012
    Applicant: MedImmune, LLC
    Inventors: Gregory Duke, George Kemble, James Young, Zhaoti Wang
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8333975
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 18, 2012
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20120301503
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: June 29, 2012
    Publication date: November 29, 2012
    Applicant: MEDIMMUNE, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
    Publication number: 20120288521
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Application
    Filed: November 15, 2011
    Publication date: November 15, 2012
    Applicant: MEDIMMUNE, LLC
    Inventors: Erich Hoffmann, Hong Jin, George Kemble, Zhongying Chen
  • REFRIGERATOR-TEMPERATURE STABLE INFLUENZA VACCINE COMPOSITIONS
    Publication number: 20120282294
    Abstract: Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
    Type: Application
    Filed: July 18, 2012
    Publication date: November 8, 2012
    Applicant: MEDIMMUNE, LLC
    Inventors: George Kemble, George Trager, Richard Schwartz
  • Methods and compositions for expressing negative-sense viral RNA in canine cells
    Patent number: 8278433
    Abstract: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: October 2, 2012
    Assignee: Medimmune, LLC
    Inventors: Gregory Duke, George Kemble, James Young, Zhaoti Wang
  • Refrigerator-temperature stable influenza vaccine compositions
    Patent number: 8247207
    Abstract: Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 21, 2012
    Assignee: Medimmune, LLC
    Inventors: George Kemble, George Trager, Richard Schwartz
  • MULTI PLASMIDS SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
    Publication number: 20120196371
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
    Type: Application
    Filed: December 1, 2011
    Publication date: August 2, 2012
    Applicant: MEDIMMUNE, LLC
    Inventors: George Kemble, Gregory Duke
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20120135023
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: December 16, 2011
    Publication date: May 31, 2012
    Applicant: Medlmmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Method for producing temperature sensitive influenza A viruses
    Patent number: 8114415
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: February 14, 2012
    Assignee: Medimmune, LLC
    Inventors: Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20120034265
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: September 28, 2011
    Publication date: February 9, 2012
    Applicant: MEDIMMUNE, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20120034264
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: June 16, 2011
    Publication date: February 9, 2012
    Applicant: MedImmune, LLC
    Inventors: Chin-Fen Yang, George Kemble
  • MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
    Publication number: 20120020997
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
    Type: Application
    Filed: August 19, 2011
    Publication date: January 26, 2012
    Inventors: Erich Hoffman, Hong Jin, Bin Lu, Greg Duke, George Kemble
  • INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
    Publication number: 20120009215
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Application
    Filed: September 12, 2011
    Publication date: January 12, 2012
    Inventors: Chin-Fen Yang, George Kemble
  • Multi plasmid system for the production of influenza virus
    Patent number: 8093033
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: January 10, 2012
    Assignee: Medimmune, LLC
    Inventors: George Kemble, Gregory Duke
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8048430
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: November 1, 2011
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Influenza hemagglutinin and neuraminidase variants
    Patent number: 8039002
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: October 18, 2011
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble