Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.

Abstract: Methods and systems are provided for assigning channels in a spatial division multiple access communication network. The network includes a plurality of conventional channels some of which are configurable to be shared concurrently by plural subscribers. The method includes determining combinations of subscribers from the existing subscribers. Enhancement activities are invoked to create optimal combinations of existing subscribers. Existing subscribers are reassigned as necessary to share channels thereby freeing resources for new subscribers.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.

Abstract: The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract: Methods and systems are provided for assigning channels in a spatial division multiple access communication network. The network includes a plurality of conventional channels some of which are configurable to be shared concurrently by plural subscribers. The method includes determining combinations of subscribers from the existing subscribers. Existing subscribers are reassigned to share channels thereby freeing resources for new subscribers.

Abstract: Methods and systems are provided for assigning channels in a spatial division multiple access communication network. The network includes a plurality of conventional channels some of which are configurable to be shared concurrently by plural subscribers. The method includes determining combinations of subscribers from the existing subscribers. Enhancement activities are invoked to create optimal combinations of existing subscribers. Existing subscribers are reassigned as necessary to share channels thereby freeing resources for new subscribers.

Abstract: A non intrusive isolation testing method for each of the positive and negative input (in+ & in−) to each comparator in the array is provided. Isolation does not affect the read capability of the comparator and therefore characterization of the comparator is accomplished by using the normal read circuits of the one time programmable (OTP) array. The isolation method relies on gating the control signals by using test signals; as a result inputs to a comparator are not affected electrically. Each input has four possible control signals and therefore needs four gating test signal drivers and so a total of 16 input combinations are available to each comparator.

Abstract: In a method of measuring fuse resistance in a fuse array, the P-MOS switches used for row address are replaced by a pass-gate device comprising an N-MOS in parallel with a P-MOS, with a close to zero voltage drop. By this means a reduced power source current is applied across the fuse. The voltage drop is measured and the resistance obtained. Thus non-destructive testing is carried out as compared to destructive testing with the prior art method.

Abstract: A non intrusive isolation testing method for each of the positive and negative input (in+ & in−) to each comparator in the array is provided. Isolation does not affect the read capability of the comparator and therefore characterization of the comparator is accomplished by using the normal read circuits of the one time programmable (OTP) array. The isolation method relies on gating the control signals by using test signals; as a result inputs to a comparator are not affected electrically. Each input has four possible control signals and therefore needs four gating test signal drivers and so a total of 16 input combinations are available to each comparator.

Abstract: In a method of measuring fuse resistance in a fuse array, the P-MOS switches used for row address are replaced by a pass-gate device comprising an N-MOS in parallel with a P-MOS, with a close to zero voltage drop. By this means a reduced power source current is applied across the fuse. The voltage drop is measured and the resistance obtained. Thus non-destructive testing is carried out as compared to destructive testing with the prior art method.

Abstract: A secure one-time programmable (OTP) salicided poly fuse array (2×8) cells with a power-on or on-reset hardware security feature is proposed. The secure OTP which is based on a primitive building cell that includes a salicided poly fuse and a MOS switch, utilize the same building block of the un-secure larger OTP array. This includes an enhanced multistage track & latch sense amp, or comparator, primitive memory cells, decoders for write and read mechanism, and a similar control block.

Abstract: Comparators, memory devices, comparison methods and memory reading methods are provided. One aspect provides a comparator including an input stage having a data input adapted to receive a data voltage signal, a reference input adapted to receive a reference voltage signal, and a plurality of current sources individually coupled with one of the data input and the reference input and individually configured to convert one of the data voltage signal and the reference voltage signal to a differential current signal and to output the differential current signal; and a comparator stage including a plurality of inputs configured to receive the differential current signals from the input stage and the comparator stage being configured to compare the differential current signals and to output an output signal indicative of a comparison of the differential current signals.

Abstract: Comparators, memory devices, comparison methods and memory reading methods are provided. One aspect provides a comparator including an input stage having a data input adapted to receive a data voltage signal, a reference input adapted to receive a reference voltage signal, and a plurality of current sources individually coupled with one of the data input and the reference input and individually configured to convert one of the data voltage signal and the reference voltage signal to a differential current signal and to output the differential current signal; and a comparator stage including a plurality of inputs configured to receive the differential current signals from the input stage and the comparator stage being configured to compare the differential current signals and to output an output signal indicative of a comparison of the differential current signals.

Abstract: An integrated circuit driver drives a differential signal over a communication cable, such as a twisted-pair cable. The integrated circuit driver includes a differential pre-driver that receives an input signal having an about 50% duty cycle and produces an amplified differential signal that swings between a power rail level and a ground level. A signal conditioner circuit receives the amplified differential signal and outputs a conditioned differential signal. The conditioned differential signal swings between the power rail level and an intermediate power level. The integrated circuit driver further includes an output driver that receives the conditioned differential signal that swings between the power rail level and the intermediate power level. The output driver produces a differential output signal that is communicated to the communication cable. The differential output signal has an about zero signal crossing and maintains the about fifty percent duty cycle.

Abstract: An improved output driver that minimizes source point reflections when driving a signal on a transmission line by generating a constant source impedance. The improved output driver uses a transistor switching circuit for generating a nearly constant channel impedance when transistor switching circuit is enabled and is not operating in a saturation mode. A switched diode circuit is coupled in parallel to the transistor switching circuit for generating a nearly constant source impedance when a sufficient voltage to bias the switch diode circuit is applied. Control circuitry is coupled to both the transistor switching circuit and to the switched diode circuit for enabling and disabling the transistor switching circuit and the switched diode circuit. By alternatively enabling and disabling the transistor switching circuit and the switched diode circuit the control circuit is able to generate a constant source impedance.

Abstract: The functionality of a variable gain controlled amplifier and a tree mixer are combined to provide a variable gain controlled mixer. In constructing the combination, both the current-to-voltage conversion output stage of the mixer, and the voltage-to-current conversion input stage of the variable gain amplifier are removed. Both the variable gain stage and the mixing stage are connected in parallel to modify the input current. Other configurations are provided, including a single balanced mixer, and a folded mixer.