Patents by Inventor George Khoury

George Khoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPSTATIN ANALOGS
    Publication number: 20150329594
    Abstract: The disclosure describes compstatin analogs and methods of using such analogs for the treatment of complement-related disease and disorder.
    Type: Application
    Filed: December 19, 2013
    Publication date: November 19, 2015
    Inventors: Dimitrios Morikis, Ronald D. Gorham, JR., Christodoulos A. Floudas, Meghan L. Bellows-Peterson, George A. Khoury, Georgios Archontis, Phanourios Tamamis
  • c-Met modulators and methods of use
    Patent number: 9174947
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: November 3, 2015
    Assignee: Exelixus, Inc.
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wie Xu
  • Methods of Using C-Met Modulators
    Publication number: 20150202196
    Abstract: Disclosed are methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt thereof, in combination with gemcitabine (GEM), or a pharmaceutically acceptable salt thereof, and optionally one or more additional treatments, wherein: R1 is halo; R2 is halo; R3 is (C1-C6)alkyl; R4 is (C1-C6)alkyl; and Q is CH or N.
    Type: Application
    Filed: October 20, 2014
    Publication date: July 23, 2015
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Timothy Patrick Forsyth, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Yong Wang, Wei Xu, Diane Simeone
  • Method and apparatus for timing and/or frequency offset monitoring and handling
    Patent number: 8917663
    Abstract: Methods and apparatuses are provided for obtaining downlink or uplink signal characteristics of at least one access point in a network. The signal characteristics may be obtained through user equipment receiving the signal characteristics, through the at least one access point, or through another access point. Frequency or timing offset between two or more access points may be determined based on the obtained signal characteristics, where the frequency or timing offset may be handled through post processing. For example, a clock servo may be controlled or adjusted in response to the determined offset, the absolute frequency of a master network oscillator may be calibrated, traffic anomalies within the network may be detected and corrected, and/or respective clocks of the two or more access points may be synchronized.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 23, 2014
    Assignee: SpiderCloud Wireless, Inc.
    Inventor: Peter George Khoury
  • Non-volatile memory cell with multiple resistive sense elements sharing a common switching device
    Patent number: 8861244
    Abstract: A non-volatile memory cell array and associated method of use. In accordance with various embodiments, the array includes a plurality of programmable resistive sense elements (RSEs) coupled to a shared switching device. The switching device has a common source region and multiple drain regions, each drain region connected to an associated RSE from said plurality of RSEs.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: October 14, 2014
    Assignee: Seagate Technology LLC
    Inventors: Andrew John Carter, Maroun Georges Khoury, Yong Lu, Roger Glenn Rolbiecki
  • Human Adam-10 Inhibitors
    Publication number: 20140206865
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: SYMPHONY EVOLUTION, INC.
    Inventors: Lynne Canne Bannen, Erick Wang Co, Vasu Jammalamadaka, John M. Nuss, Moon Hwan Kim, Donna Tra Le, Amy Lew Tsuhako, Morrison B. Mac, Shumeye Mamo, Zhaoyang Wen, Wei Xu, Richard George Khoury
  • C-Met Modulators and Method of Use
    Publication number: 20140155396
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Application
    Filed: June 27, 2013
    Publication date: June 5, 2014
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wei Xu
  • c-Met Modulators and Method of Use
    Publication number: 20140155378
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Application
    Filed: May 7, 2013
    Publication date: June 5, 2014
    Applicant: Exelixis, Inc.
    Inventors: Lynne Canne Bannen, Diva Sze-ming Chan, Jeff Chen, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wei Xu
  • VERTICAL TRANSISTOR WITH HARDENING IMPLANTATION
    Publication number: 20140097400
    Abstract: A vertical transistor includes a semiconductor wafer having a plurality of pillar structures extending orthogonally from the semiconductor wafer. Each pillar structure forms a vertical pillar transistor having a top surface and a side surface orthogonal to the top surface. Then a hardening ion species is implanted into the vertical pillar transistor top surface. Then the vertical pillar transistor side surface is oxidized to form a side surface oxide layer. The side surface oxide layer is removed to form vertical pillar transistor having rounded side surfaces.
    Type: Application
    Filed: December 10, 2013
    Publication date: April 10, 2014
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Young Pil Kim, Hyung-Kew Lee, Peter Nicholas Manos, Chulmin Jung, Maroun Georges Khoury, Dadi Setiadi
  • Vertical transistor with hardening implatation
    Patent number: 8617952
    Abstract: A method includes providing a semiconductor wafer having a plurality of pillar structures extending orthogonally from the semiconductor wafer. Each pillar structure forms a vertical pillar transistor having a top surface and a side surface orthogonal to the top surface. Then a hardening species is implanted into the vertical pillar transistor top surface. Then the vertical pillar transistor side surface is oxidized to form a side surface oxide layer. The side surface oxide layer is removed to form vertical pillar transistor having rounded side surfaces.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: December 31, 2013
    Assignee: Seagate Technology LLC
    Inventors: Young Pil Kim, Hyung-Kew Lee, Peter Nicholas Manos, Chulmin Jung, Maroun Georges Khoury, Dadi Setiadi
  • 3D ARRAY WITH VERTICAL TRANSISTOR
    Publication number: 20130302948
    Abstract: A memory array includes a base circuitry layer and a plurality of memory array layers stacked sequentially to form the memory array. Each memory array layer is electrically coupled to the base circuitry layer. Each memory array layer includes a plurality of memory units. Each memory unit includes a vertical pillar transistor electrically coupled to a memory cell.
    Type: Application
    Filed: July 22, 2013
    Publication date: November 14, 2013
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Dadi Setiadi, Peter Nicholas Manos, Hsing-Kuen Liou, Paramasivan Kamatchi Subramanian, Young Pil Kim, Hyung-Kyu Lee, Maroun Georges Khoury, Chulmin Jung
  • c-Met Modulators and Method of Use
    Publication number: 20130252940
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Application
    Filed: May 7, 2013
    Publication date: September 26, 2013
    Applicant: Exelixis, Inc.
    Inventors: Lynne Canne Bannen, Diva Sze-ming Chan, Jeff Chen, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wei Xu
  • Bipolar select device for resistive sense memory
    Patent number: 8514608
    Abstract: A resistive sense memory apparatus includes a bipolar select device having a semiconductor substrate, a plurality of collector contacts disposed in a first side of the of the semiconductor substrate, an emitter contact layer disposed in a second side of the semiconductor substrate, and a base layer separating the plurality of collector contacts from the emitter contact layer. Each collector contact is electrically isolated from each other. A resistive sense memory cells is electrically coupled to each collector contacts and a bit line. The base layer and the emitter contact layer provide an electrical path for the plurality of collector contacts.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 20, 2013
    Assignee: Seagate Technology LLC
    Inventor: Maroun Georges Khoury
  • Polarity dependent switch for resistive sense memory
    Patent number: 8508980
    Abstract: A memory unit includes a resistive sense memory cell configured to switch between a high resistance state and a low resistance state upon passing a current through the resistive sense memory cell and a semiconductor transistor in electrical connection with the resistive sense memory cell. The semiconductor transistor includes a gate element formed on a substrate. The semiconductor transistor includes a source contact and a bit contact. The gate element electrically connects the source contact and the bit contact. The resistive sense memory cell electrically is connected to the bit contact. The source contact is more heavily implanted with dopant material then the bit contact.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: August 13, 2013
    Assignee: Seagate Technology LLC
    Inventors: Chulmin Jung, Maroun Georges Khoury, Yong Lu, Young Pil Kim
  • Apparatus for variable resistive memory punchthrough access method
    Patent number: 8508981
    Abstract: Variable resistive punchthrough access methods are described. The methods include switching a variable resistive data cell from a high resistance state to a low resistance state by passing a write current through the magnetic tunnel junction data cell in a first direction. The write current is provided by a transistor being electrically coupled to the variable resistive data cell and a source line. The write current passes through the transistor in punchthrough mode.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: August 13, 2013
    Assignee: Seagate Technology LLC
    Inventors: Maroun Georges Khoury, Hongyue Liu, Brian Lee, Andrew John Gjevre Carter
  • C-met modulators and method of use
    Patent number: 8497284
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: July 30, 2013
    Assignee: Exelixis, Inc.
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wei Xu
  • c-Met modulators and method of use
    Patent number: 8476298
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: July 2, 2013
    Assignee: Exelixis, Inc.
    Inventors: Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrisson B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wie Xu
  • Human Adam-10 Inhibitors
    Publication number: 20130144056
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
    Type: Application
    Filed: July 3, 2012
    Publication date: June 6, 2013
    Applicant: SYMPHONY EVOLUTION, INC.
    Inventors: Lynne Canne Bannen, Erick W. Co, Vasu Jammalamadaka, John M. Nuss, Moon Hwan Kim, Donna Tra Le, Amy Lew Tsuhako, Morrison B. Mac, Shumeye Mamo, Zhaoyang Wen, Wei Xu, Richard George Khoury
  • APPARATUS FOR VARIABLE RESISTIVE MEMORY PUNCHTHROUGH ACCESS METHOD
    Publication number: 20120230084
    Abstract: Variable resistive punchthrough access methods are described. The methods include switching a variable resistive data cell from a high resistance state to a low resistance state by passing a write current through the magnetic tunnel junction data cell in a first direction. The write current is provided by a transistor being electrically coupled to the variable resistive data cell and a source line. The write current passes through the transistor in punchthrough mode.
    Type: Application
    Filed: May 23, 2012
    Publication date: September 13, 2012
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Maroun Georges Khoury, Hongyue Liu, Brian Lee, Andrew John Gjevre Carter
  • METHOD AND APPARATUS FOR TIMING AND/OR FREQUENCY OFFSET MONITORING AND HANDLING
    Publication number: 20120195256
    Abstract: Methods and apparatuses are provided for obtaining downlink or uplink signal characteristics of at least one access point in a network. The signal characteristics may be obtained through user equipment receiving the signal characteristics, through the at least one access point, or through another access point. Frequency or timing offset between two or more access points may be determined based on the obtained signal characteristics, where the frequency or timing offset may be handled through post processing. For example, a clock servo may be controlled or adjusted in response to the determined offset, the absolute frequency of a master network oscillator may be calibrated, traffic anomalies within the network may be detected and corrected, and/or respective clocks of the two or more access points may be synchronized.
    Type: Application
    Filed: November 29, 2011
    Publication date: August 2, 2012
    Applicant: SpiderCloud Wireless, Inc.
    Inventor: Peter George Khoury