Abstract: A system for producing plastic containers with a heating device for heating plastic preforms, wherein the heating device has a transport device for transporting plastic preforms along a predetermined first transport path, and a plurality of holding devices for holding the plastic preforms and at least one heating device which heats the plastic preforms during the transport thereof and comprising a forming device for forming the plastic preforms to form plastic containers. The forming device is configured for expanding the plastic preforms heated by the heating device by applying a flowable medium, and includes a plurality of forming stations which form the plastic preforms to form the plastic containers. Both the heating device and the forming device have changeable elements, wherein the system has a changing device configured for changing both changeable elements of the heating device and changeable elements of the forming device.

Abstract: A workpiece holding device for holding a workpiece in a heat treatment system while the workpiece undergoes a thermal expansion and/or contraction includes at least two clamping units configured to apply a radial and/or an axial clamping force to the workpiece to hold the workpiece in the workpiece holding device in a predefined position, and at least three support units configured to support the workpiece. At least one of the support units includes a carrier and an exchangeable support element attached to the carrier, the exchangeable support element being configured to contact and rotatably support the workpiece in the predefined position.

Abstract: A workpiece holding device for holding a workpiece in a heat treatment system while the workpiece undergoes a thermal expansion and/or contraction includes at least two clamping units configured to apply a radial and/or an axial clamping force to the workpiece to hold the workpiece in the workpiece holding device in a predefined position, and at least three support units configured to support the workpiece. A first one of the at least three support units includes a first cylinder configured to support the workpiece, the first cylinder having a longitudinal axis and being configured to rotate around the longitudinal axis.

Abstract: A workpiece holding device for holding a workpiece in a heat treatment system while the workpiece undergoes a thermal expansion and/or contraction includes at least two clamping units configured to apply a radial and/or an axial clamping force to the workpiece to hold the workpiece in the workpiece holding device in a predefined position and a drive unit configured to rotate the workpiece in the workpiece holding device. The at least two clamping units may be configured to adjust their position relative to the holding device to maintain the clamping force during the thermal expansion and/or contraction of the workpiece.

Abstract: A workpiece holding device for holding a workpiece in a heat treatment system while the workpiece undergoes a thermal expansion and/or contraction includes at least two clamping units configured to apply a radial and/or an axial clamping force to the workpiece to hold the workpiece in the workpiece holding device in a predefined position, and an adjustment mechanism for setting the at least two clamping units to synchronously apply a substantially identical radial and/or axial clamping force to the workpiece.

Abstract: A workpiece holding device for holding a workpiece having a substantially radial inner surface and a substantially radial outer surface in a heat treatment system while the workpiece undergoes a thermal expansion and/or contraction, the workpiece holding device includes at least two clamping units configured to apply a radial clamping force to the workpiece to hold the workpiece in the workpiece holding device in a predefined position, each of the at least two clamping units including a clamping element configured to abut against the radially inner surface and/or against the radially outer surface of the workpiece and to apply a radial clamping force to the workpiece.

Abstract: An inductive hardening system for hardening a component includes a holding unit for holding the component, an induction coil configured to induce an electrical current in the component to heat the component, and a control unit configured to control the induction coil to produce a first amount of heat per unit area in the component until a predetermined temperature is reached and/or a predetermined time is elapsed and after the predetermined temperature is reached and/or the predetermined time is elapsed, to control the induction coil to produce a second amount of heat per unit area in the component, the second amount of heat being from 3% to 80% of the first amount of heat.

Abstract: An induction hardening system for inductively hardening a component includes a first inductor group with at least two inductors configured to heat a region to be hardened on the component, a drive unit configured to move the component along the at least two inductors, and a generator. The at least two inductors are electrically energized by the generator, and the generator is configured to send a current of a same frequency and a same strength to the at least two inductors of the first inductor group.

Abstract: Described herein are compounds, compositions and methods useful for inhibiting Kelch-like ECH-associated protein 1 (KEAP1). The compounds, compositions and methods described herein are useful for treating diseases, disorders or conditions associated with KEAP1.

Abstract: An orifice-type quenching nozzle for an induction hardening system includes a body having a plurality of nozzle orifices configured to apply a quenching fluid onto a to-be-quenched workpiece. The nozzle orifices are arranged on at least one surface of the body in rows and in columns, and the plurality of nozzle orifices are positioned such that each nozzle orifice is located a same distance from each directly adjacent nozzle orifice.

Abstract: This invention provides for a network of cell-derived microfilaments. Also provided are methods of producing a network of microfilaments via culturing cells in a matrix support and cell culture medium wherein the cells proliferate and form aggregated cell masses, which produce microfilaments external to and surrounding the cell masses, and wherein the extracellular microfilaments connect and form a continuous extracellular microfilament network, and methods for treating a medical condition as well as facilitating wound repair and tissue regeneration comprising applying the microfilament network to an area in need of treatment.

Abstract: This invention provides for a network of cell-derived microfilaments. Also provided are methods of producing a network of microfilaments via culturing cells in a matrix support and cell culture medium wherein the cells proliferate and form aggregated cell masses, which produce microfilaments external to and surrounding the cell masses, and wherein the extracellular microfilaments connect and form a continuous extracellular microfilament network, and methods for treating a medical condition as well as facilitating wound repair and tissue regeneration comprising applying the microfilament network to an area in need of treatment.

Abstract: This invention provides for methods and compositions for generation of cytocapsulae and cytocapsular tubes in a 3D matrix.

Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.

Abstract: A bearing ring for a rolling-element bearing or plain bearing has at least one first region that is inductively hardened or is configured to be inductively hardened and at least one second region that is not inductively hardened and is not intended to be inductively hardened, and the at least one second region includes at least one stress-relief recess and/or at least one stress-relief projection.

Abstract: Described herein are methods and compositions relating to nanodiscs, e.g., phospholipid bilayers with a proteinaceous belt or border. Further provided herein are loopable membrane scaffold proteins, e.g., for forming nanodiscs.

Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.

Abstract: An orifice-type quenching nozzle for an induction hardening system includes a body having a plurality of nozzle orifices configured to apply a quenching fluid onto a to-be-quenched workpiece. The nozzle orifices are arranged on at least one surface of the body in rows and in columns, and the plurality of nozzle orifices are positioned such that each nozzle orifice is located a same distance from each directly adjacent nozzle orifice.

Abstract: An inductor for an induction hardening system includes a heating element for heating a heating zone of a workpiece, and the heating element includes a first induction coil and a second induction coil and a gas escape device disposed between the first induction coil and the second induction coil. The gas escape device is configured to substantially prevent a liquid from a quenching device from reaching the heating zone while the heating zone is being heated by the first and second inductors.

Abstract: The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell.