Abstract: A bearing cage for a rolling-element bearing includes a plurality of bearing cage segments configured to receive rolling elements in rolling-element pockets. Also included is at least one assembly wire, and each of the cage segments includes a coupling arrangement configured to thread the bearing cage segment onto the at least one assembly wire such that at least one rolling-element pocket is formed by two of the plurality of bearing cage segments adjacent in the circumferential direction that are threaded on the assembly wire. The bearing cage also includes an assembly device configured to convey an end of the assembly wire from an installation position to an axially far-side coupling arrangement of a bearing cage segment, through the axially far-side coupling arrangement of all bearing cage segments located on a bearing inner ring, and back again towards the installation position.

Abstract: (Modified) rice endosperm protein is used as novel protective hydrocolloid for active ingredients, especially fat-soluble active ingredients and/or colorants. Included are compositions comprising (modified) rice endosperm protein and at least one active ingredient and to their manufacture, as well as to the (modified) rice endosperm protein itself and its manufacture. These compositions are used for the enrichment, fortification and/or coloration of food, beverages, animal feed, personal care or pharmaceutical compositions, and to food, beverages, animal feed, personal care and pharmaceutical compositions containing such a (modified) rice endosperm protein and such a composition, respectively.

Abstract: The present invention provides pharmaceutical release systems comprising an therapeutically effective amount of flibanserin.

Abstract: Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature-lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.

Abstract: A method for manufacturing a rolling-element bearing cage includes clamping a cage blank in the radial direction using a clamping element in a first position where the cage blank is processed. Then, the cage blank is rotated relative to the clamping element to a second position where the cage blank is further processed. A device for manufacturing a rolling-element bearing cage includes the clamping element, which remain stationary together with a tool for processing the cage blank, while only the cage blank is rotated.

Abstract: Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.

Abstract: A bearing cage for a rolling-element bearing includes a plurality of bearing cage segments configured to receive rolling elements in rolling-element pockets. Also included is at least one assembly wire, and each of the cage segments includes a coupling arrangement configured to thread the bearing cage segment onto the at least one assembly wire such that at least one rolling-element pocket is formed by two of the plurality of bearing cage segments adjacent in the circumferential direction that are threaded on the assembly wire. The bearing cage also includes an assembly device configured to convey an end of the assembly wire from an installation position to an axially far-side coupling arrangement of a bearing cage segment, through the axially far-side coupling arrangement of all bearing cage segments located on a bearing inner ring, and back again towards the installation position.

Abstract: Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature-lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.

Abstract: Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading cells with labeled substrate (e.g. labeled by 13C, 15N, or 31P). The methods allow for easy identification of metabolites that are differentially generated in cells of different phenotypes. The new methods for unbiased multi-dimensional NMR screening and rapid and efficient analysis of the NMR screening identify differentially expressed metabolites in different cell or tissue types. Analysis of the differentially expressed metabolites can present unique druggable targets to which small molecule therapeutics can be designed.

Abstract: A bearing cage for a rolling element bearing includes a plurality of individual bearing cage segments configured to respectively accommodate rolling elements in rolling element pockets formed by the bearing cage segments. Each bearing cage segment includes a first coupling device disposed on a first axial end thereof. A first lamellar support ring defines first and second ring halves that are connected to each other, are axially adjacent to each other are biased towards each other. The first ring half extends through the respective first coupling devices of the plurality of bearing cage segments and the second ring half is disposed on an axially-inner side or an axially-outer side of the first coupling devices such that the first coupling devices are clamped between the first and second ring halves.

Abstract: The present invention relates to the identification of molecular mechanisms associated with multidrug resistance (MDR) in fungal infections. More specifically, fungi harbor a nuclear receptor-like pathway controlling MDR, which represents a novel therapeutic target for the treatment of MDR in pathogenic fungi such as C. glabrata.

Abstract: The invention is directed to a pharmaceutical controlled release system for administration, particularly oral administration, of active substances with pH-dependent solubilities, comprising a) a core material containing or consisting of one or more pharmaceutically acceptable pH modifiers; b) optionally an insulating layer, c) a first layer containing or consisting of one or more pharmaceutically acceptable water-insoluble polymers; d) a second layer containing or consisting of at least one active substance having a pH-dependent solubility; e) a third layer containing or consisting of one or more pharmaceutically acceptable polymers having anionic or no ionic groups; and f) optionally a fourth layer, preferably in form of an outer coating layer. It is provided a pH-independent release profile of active substances having pH-dependent solubilities in vitro and vivo.

Abstract: A bearing cage for a rolling element bearing includes a plurality of individual bearing cage segments configured to respectively accommodate rolling elements in rolling element pockets formed by the bearing cage segments. Each bearing cage segment includes a first coupling device disposed on a first axial end thereof. A first lamellar support ring defines first and second ring halves that are connected to each other, are axially adjacent to each other are biased towards each other. The first ring half extends through the respective first coupling devices of the plurality of bearing cage segments and the second ring half is disposed on an axially-inner side or an axially-outer side of the first coupling devices such that the first coupling devices are clamped between the first and second ring halves.

Abstract: The present invention relates to a multiple unit pellet system (MUPS) in form of a tablet containing a pharmaceutically active ingredient, characterized in that the MUPS is an optionally coated immediate release pharmaceutical dosage form for oral administration.

Abstract: Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.

Abstract: A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.

Abstract: Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.

Abstract: A roller bearing element for a large roller bearing includes the following features: at least one contact zone for a roller bearing counter element, the contact zone has an induction-hardened surface layer, the roller bearing element is comprised of a steel, which includes an admixture of carbon of at least 0.46 mass %.

Abstract: Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature- lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.

Abstract: The present invention provides pharmaceutical release systems comprising an therapeutically effective amount of flibanserin.