Patents by Inventor Gregory S. Hamilton

Gregory S. Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using neurotrophic sulfonamide compounds
    Patent number: 5968957
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule piperidine and pyrrolidine sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: October 19, 1999
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • N-linked ureas and carbamates of piperidyl thioesters
    Patent number: 5958949
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: September 28, 1999
    Assignee: GPI NIL Holdings Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Wei Huang
  • Pyrrolidine carboxylate hair revitalizing agents
    Patent number: 5945441
    Abstract: This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate compounds.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: August 31, 1999
    Assignee: Gpi Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • N-linked ureas and carbamates of heterocyclic thioesters
    Patent number: 5935989
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: August 10, 1999
    Assignee: GPI NIL Holdings Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Wei Huang
  • N-linked sulfonamides of heterocyclic thioesters
    Patent number: 5874449
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: February 23, 1999
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Wei Huang
  • Small molecule inhibitors of rotamase enzyme activity
    Patent number: 5859031
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: January 12, 1999
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity
    Patent number: 5846981
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: December 8, 1998
    Assignees: GPI NIL Holdings Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • N-oxides of heterocyclic esters, amides, thioesters, and ketones
    Patent number: 5846979
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: December 8, 1998
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Eric S. Burak
  • Inhibitors of rotamase enzyme activity
    Patent number: 5843960
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: December 1, 1998
    Assignees: GPI Nil Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Heterocyclic esters and amides
    Patent number: 5801187
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: September 1, 1998
    Assignee: GPI-NIL Holdings, Inc.
    Inventors: Jia-He Li, Gregory S. Hamilton
  • Rotamase enzyme activity inhibitors
    Patent number: 5801197
    Abstract: This invention relates to the method of using specially formulated neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: September 1, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Inhibitors of rotamase enzyme activity
    Patent number: 5798355
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 25, 1998
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Small molecule inhibitors of rotamase enzyme activity
    Patent number: 5795908
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: August 18, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Heterocyclic thioesters
    Patent number: 5786378
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic thioesters and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: July 28, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Method of using neurotrophic sulfonamide compounds
    Patent number: 5721256
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: February 24, 1998
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
    Patent number: 5696135
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: December 9, 1997
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins Univ. School of Medicines
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton
  • Small molecule inhibitors of rotamase enzyme
    Patent number: 5614547
    Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 25, 1997
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Anti-inflammatory benzoic acid derivatives
    Patent number: 5530157
    Abstract: Novel benzoic acid derivatives have the formula: ##STR1## wherein --X-- represents C.sub.1 to C.sub.6 alkylene, C.sub.2 to C.sub.6 alkenylene or a divalent moiety having the structure --(CH.sub.2).sub.m --Z-- in which m is an integer from 0 to 3 and Z represents --O--, --S-- or --NH--;--Y-- represents a direct bond, C1 to C.sub.6 alkylene, C.sub.2 to C.sub.6 alkenylene or a divalent moiety having the structure --(CH.sub.2).sub.m --Z--(CH.sub.2).sub.n in which m and n are each, independently, an integer from 0 to 3 and --Z-- represents --O--, --S-- or --NH--;R represents a 5- or 6-membered carbocyclic or heterocyclic ring or a carbocyclic or heterocyclic fused ring system containing up to 10 members in the ring, which carbocyclic, heterocyclic or fused ring system may be saturated or unsaturated and may contain up to two substituents selected from lower alkyl, methoxy, halo and trifluoromethyl; andR.sup.1 and R.sup.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: June 25, 1996
    Assignee: Scios Nova Inc.
    Inventors: Richard Mewshaw, Gregory S. Hamilton
  • Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors
    Patent number: 5510338
    Abstract: The present invention pertains to antagonists of excitatory amino acid receptors, their method of preparation as well as compositions pertaining to them, which have the general formula: ##STR1## wherein n is 0, 1, 2, or 3; R1 and R.sub.2 are selected from the group consisting of hydrogen, halogen, halomethyl, nitro, amino, alkoxy, hydroxyl, hydroxymethyl, C.sub.1 to C.sub.6 lower alkyl and C.sub.7 to C.sub.12 higher alkyl, aryl and aralkyl; and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: April 23, 1996
    Assignee: Guilford Pharmaceuticals Inc.
    Inventor: Gregory S. Hamilton
  • .omega.-[2-(tetrazolylalkyl)cyclohexyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors
    Patent number: 5426114
    Abstract: The present invention pertains to antagonists of excitatory amino acid receptors, their method or preparation as well as compositions pertaining to them, which have the general formula: ##STR1## wherein R1 and R2 are selected from the group of hydrogen and C1 to C6 lower alkyl; the stereoisomers being in their resolved or racemic form; n and m are independently 0, 1, 2, or 3; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: June 20, 1995
    Assignee: Guilford Pharmaceuticals Inc.
    Inventor: Gregory S. Hamilton