Patents by Inventor Gregory S. Hamilton

Gregory S. Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic esters and amides
    Publication number: 20030032635
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic ester and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Application
    Filed: June 24, 2002
    Publication date: February 13, 2003
    Inventors: Jia-He Li, Gregory S. Hamilton
  • Small molecule inhibitors of rotamase enzyme activity
    Patent number: 6509477
    Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: January 21, 2003
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Inhibitors of cyclophilin rotamase activity
    Publication number: 20030013645
    Abstract: This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Application
    Filed: July 22, 2002
    Publication date: January 16, 2003
    Inventors: Joseph P. Steiner, Gregory S. Hamilton, Solomon H. Snyder
  • N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
    Patent number: 6506788
    Abstract: The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: January 14, 2003
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity
    Patent number: 6500843
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: December 31, 2002
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Pyrrolidine derivatives and processes for preparing same
    Patent number: 6500959
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: December 31, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Pyrrolidine derivative hair growth compositions and uses
    Publication number: 20020198250
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.
    Type: Application
    Filed: May 20, 2002
    Publication date: December 26, 2002
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Publication number: 20020193420
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Application
    Filed: March 25, 2002
    Publication date: December 19, 2002
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • N-oxides of heterocyclic esters, amides, thioesters, and ketones
    Patent number: 6486151
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: November 26, 2002
    Assignee: GPI NIL Holdings Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Eric S. Burak
  • Trisubstituted carbocyclic cyclophilin binding compounds and their use
    Publication number: 20020165275
    Abstract: The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.
    Type: Application
    Filed: January 25, 2002
    Publication date: November 7, 2002
    Inventors: Yong-Qian Wu, Sergei Belyakov, Gregory S. Hamilton, David Limburg, Joseph P. Steiner, Mark Vaal, Ling Wei, Douglas Wilkinson
  • Cyclic ester or amide derivatives
    Patent number: 6462072
    Abstract: This invention relates to low molecular weight, small molecule cyclic esters and amides having an affinity for FKBP-type immunophilins, pharmaceutical compositions comprising the same, and methods of using the same to effect a neuronal activity.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: October 8, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, David C. Limburg
  • Bisubstituted carbocyclic cyclophilin binding compounds and their use
    Publication number: 20020127605
    Abstract: The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo- or heterocyclic groups are attached to a central saturated, partially saturated, or aromatic 5-6 membered carbocyclic ring by a combination of straight or branched linker chains. The invention further relates to pharmaceutical compositions comprising one or more of the said compounds, and to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders, such as neurological disorders, hair loss disorders, ischemic disorders, and disorders caused by viral or protozoan infection.
    Type: Application
    Filed: November 28, 2001
    Publication date: September 12, 2002
    Inventors: Gregory S. Hamilton, Sergei Belyakov, Mark Vaal, Ling Wei, Yong-Qian Wu, Joseph P. Steiner
  • Methods of using inhibitors of cyclophilin rotamase activity to affect neurological activity
    Patent number: 6444643
    Abstract: This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: September 3, 2002
    Assignees: Guilford Pharmaceuticals Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Gregory S. Hamilton, Solomon H. Snyder
  • N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
    Patent number: 6429215
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: August 6, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • AZA compounds, pharmaceutical compositions and methods of use
    Patent number: 6417189
    Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: July 9, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Yong-Qian Wu, Wei Huang, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Patent number: 6417209
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: July 9, 2002
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
    Patent number: 6399648
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-Oxides of heterocyclic esters, amides, thioesters, or ketones
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: June 4, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
    Publication number: 20020065297
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
    Type: Application
    Filed: June 29, 2001
    Publication date: May 30, 2002
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Small molecule carbamates or ureas for vision and memory disorders
    Patent number: 6395758
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule carbamates and ureas.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: May 28, 2002
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Hydantoin derivative compounds, pharmace utical compositions, and methods of using same
    Publication number: 20020058685
    Abstract: The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.
    Type: Application
    Filed: December 21, 2000
    Publication date: May 16, 2002
    Inventor: Gregory S. Hamilton